Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224100847> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4224100847 endingPage "110" @default.
- W4224100847 startingPage "110" @default.
- W4224100847 abstract "Colony-stimulating factor 3 (CSF3), more commonly known as granulocyte colony-stimulating factor (G-CSF), acts via a specific cell surface receptor CSF3R (or G-CSFR) to regulate hematopoiesis, with a particularly key role in the myeloid cell lineage where it impacts the development and function of neutrophilic granulocytes. Zebrafish possess a conserved CSF3R homologue, Csf3r, which is involved in both steady-state and emergency myelopoiesis, as well as regulating early myeloid cell migration. Two CSF3 proteins have been identified in zebrafish, Csf3a and Csf3b.This study investigated the roles of the Csf3a and Csf3b ligands as well as the downstream Janus kinase (JAK) and phosphatidylinositol 3-kinase (PI3K) pathways in mediating the effects of Csf3r in early myeloid cell development and function using gene knockdown and pharmacologic approaches.This study revealed that both Csf3a and Csf3b contribute to the developmental and emergency production of early myeloid cells, but Csf3a is responsible for the developmental migration of early neutrophils whereas Csf3b plays the major role in their wounding-induced migration, differentially participated in these responses, as did several downstream signaling pathways. Both JAK and PI3K signaling were required for developmental production and migration of early myeloid cells, but PI3K signaling was required for emergency production and initial migration in response to wounding, while JAK signaling mediated retention at the site of wounding.This study has revealed both distinct and overlapping functions for Csf3a and Csf3b and the downstream JAK and PI3K signaling pathways in early myeloid cell production and function." @default.
- W4224100847 created "2022-04-19" @default.
- W4224100847 creator A5006743069 @default.
- W4224100847 creator A5014284180 @default.
- W4224100847 creator A5017906784 @default.
- W4224100847 creator A5025817571 @default.
- W4224100847 creator A5052467613 @default.
- W4224100847 creator A5061522236 @default.
- W4224100847 date "2022-03-28" @default.
- W4224100847 modified "2023-10-16" @default.
- W4224100847 title "Granulocyte Colony-Stimulating Factor Mediated Regulation of Early Myeloid Cells in Zebrafish" @default.
- W4224100847 doi "https://doi.org/10.31083/j.fbl2704110" @default.
- W4224100847 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35468669" @default.
- W4224100847 hasPublicationYear "2022" @default.
- W4224100847 type Work @default.
- W4224100847 citedByCount "6" @default.
- W4224100847 countsByYear W42241008472022 @default.
- W4224100847 countsByYear W42241008472023 @default.
- W4224100847 crossrefType "journal-article" @default.
- W4224100847 hasAuthorship W4224100847A5006743069 @default.
- W4224100847 hasAuthorship W4224100847A5014284180 @default.
- W4224100847 hasAuthorship W4224100847A5017906784 @default.
- W4224100847 hasAuthorship W4224100847A5025817571 @default.
- W4224100847 hasAuthorship W4224100847A5052467613 @default.
- W4224100847 hasAuthorship W4224100847A5061522236 @default.
- W4224100847 hasBestOaLocation W42241008471 @default.
- W4224100847 hasConcept C104317684 @default.
- W4224100847 hasConcept C109159458 @default.
- W4224100847 hasConcept C203014093 @default.
- W4224100847 hasConcept C2776878037 @default.
- W4224100847 hasConcept C2779282312 @default.
- W4224100847 hasConcept C28328180 @default.
- W4224100847 hasConcept C502942594 @default.
- W4224100847 hasConcept C54355233 @default.
- W4224100847 hasConcept C62478195 @default.
- W4224100847 hasConcept C86554907 @default.
- W4224100847 hasConcept C86803240 @default.
- W4224100847 hasConcept C95444343 @default.
- W4224100847 hasConcept C95862172 @default.
- W4224100847 hasConceptScore W4224100847C104317684 @default.
- W4224100847 hasConceptScore W4224100847C109159458 @default.
- W4224100847 hasConceptScore W4224100847C203014093 @default.
- W4224100847 hasConceptScore W4224100847C2776878037 @default.
- W4224100847 hasConceptScore W4224100847C2779282312 @default.
- W4224100847 hasConceptScore W4224100847C28328180 @default.
- W4224100847 hasConceptScore W4224100847C502942594 @default.
- W4224100847 hasConceptScore W4224100847C54355233 @default.
- W4224100847 hasConceptScore W4224100847C62478195 @default.
- W4224100847 hasConceptScore W4224100847C86554907 @default.
- W4224100847 hasConceptScore W4224100847C86803240 @default.
- W4224100847 hasConceptScore W4224100847C95444343 @default.
- W4224100847 hasConceptScore W4224100847C95862172 @default.
- W4224100847 hasIssue "4" @default.
- W4224100847 hasLocation W42241008471 @default.
- W4224100847 hasLocation W42241008472 @default.
- W4224100847 hasLocation W42241008473 @default.
- W4224100847 hasOpenAccess W4224100847 @default.
- W4224100847 hasPrimaryLocation W42241008471 @default.
- W4224100847 hasRelatedWork W166913720 @default.
- W4224100847 hasRelatedWork W1977287641 @default.
- W4224100847 hasRelatedWork W1994694513 @default.
- W4224100847 hasRelatedWork W2009890397 @default.
- W4224100847 hasRelatedWork W2045753644 @default.
- W4224100847 hasRelatedWork W2086226053 @default.
- W4224100847 hasRelatedWork W2129879298 @default.
- W4224100847 hasRelatedWork W3092689953 @default.
- W4224100847 hasRelatedWork W3201543112 @default.
- W4224100847 hasRelatedWork W3207386056 @default.
- W4224100847 hasVolume "27" @default.
- W4224100847 isParatext "false" @default.
- W4224100847 isRetracted "false" @default.
- W4224100847 workType "article" @default.