Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224102221> ?p ?o ?g. }
- W4224102221 endingPage "100252" @default.
- W4224102221 startingPage "100252" @default.
- W4224102221 abstract "Three-dimensional (3D) engineered cardiovascular tissues have shown great promise to replace damaged structures. Specifically, tissue engineering vascular grafts (TEVG) have the potential to replace biological and synthetic grafts. We aimed to design an in-vitro patient-specific patch based on a hybrid 3D print combined with vascular smooth muscle cells (VSMC) differentiation. Based on the medical images of a 2 months-old girl with aortic arch hypoplasia and using computational modelling, we evaluated the most hemodynamically efficient aortic patch surgical repair. Using the designed 3D patch geometry, the scaffold was printed using a hybrid fused deposition modelling (FDM) and electrospinning techniques. The scaffold was seeded with multipotent mesenchymal stem cells (MSC) for later maturation to derived VSMC (dVSMC). The graft showed adequate resistance to physiological aortic pressure (burst pressure 101 ± 15 mmHg) and a porosity gradient ranging from 80 to 10 μm allowing cells to infiltrate through the entire thickness of the patch. The bio-scaffolds showed good cell viability at days 4 and 12 and adequate functional vasoactive response to endothelin-1. In summary, we have shown that our method of generating patient-specific patch shows adequate hemodynamic profile, mechanical properties, dVSMC infiltration, viability and functionality. This innovative 3D biotechnology has the potential for broad application in regenerative medicine and potentially in heart disease prevention." @default.
- W4224102221 created "2022-04-19" @default.
- W4224102221 creator A5013993769 @default.
- W4224102221 creator A5014063830 @default.
- W4224102221 creator A5016077959 @default.
- W4224102221 creator A5018407289 @default.
- W4224102221 creator A5018936012 @default.
- W4224102221 creator A5020508062 @default.
- W4224102221 creator A5023817593 @default.
- W4224102221 creator A5031806355 @default.
- W4224102221 creator A5041115971 @default.
- W4224102221 creator A5042514167 @default.
- W4224102221 creator A5046711583 @default.
- W4224102221 creator A5048564331 @default.
- W4224102221 creator A5050903931 @default.
- W4224102221 creator A5071005607 @default.
- W4224102221 creator A5072346483 @default.
- W4224102221 creator A5086439485 @default.
- W4224102221 date "2022-03-01" @default.
- W4224102221 modified "2023-10-16" @default.
- W4224102221 title "Tissue engineered in-vitro vascular patch fabrication using hybrid 3D printing and electrospinning" @default.
- W4224102221 cites W1490886285 @default.
- W4224102221 cites W1536931258 @default.
- W4224102221 cites W192738711 @default.
- W4224102221 cites W1928785183 @default.
- W4224102221 cites W1955448176 @default.
- W4224102221 cites W1963622447 @default.
- W4224102221 cites W1972659765 @default.
- W4224102221 cites W1983332762 @default.
- W4224102221 cites W1984685797 @default.
- W4224102221 cites W1985969564 @default.
- W4224102221 cites W1998319326 @default.
- W4224102221 cites W1998427002 @default.
- W4224102221 cites W2002907090 @default.
- W4224102221 cites W2005347754 @default.
- W4224102221 cites W2013811033 @default.
- W4224102221 cites W2020162824 @default.
- W4224102221 cites W2020287639 @default.
- W4224102221 cites W2026038729 @default.
- W4224102221 cites W2035002231 @default.
- W4224102221 cites W2036609427 @default.
- W4224102221 cites W2041373058 @default.
- W4224102221 cites W2042349974 @default.
- W4224102221 cites W2047031906 @default.
- W4224102221 cites W2048644480 @default.
- W4224102221 cites W2056163086 @default.
- W4224102221 cites W2063736240 @default.
- W4224102221 cites W2065678169 @default.
- W4224102221 cites W2069450287 @default.
- W4224102221 cites W2072352657 @default.
- W4224102221 cites W2084515183 @default.
- W4224102221 cites W2085650250 @default.
- W4224102221 cites W2093755261 @default.
- W4224102221 cites W2117071187 @default.
- W4224102221 cites W2118571692 @default.
- W4224102221 cites W2124385942 @default.
- W4224102221 cites W2134294383 @default.
- W4224102221 cites W2146703042 @default.
- W4224102221 cites W2153030094 @default.
- W4224102221 cites W2153303181 @default.
- W4224102221 cites W2163976095 @default.
- W4224102221 cites W2185825455 @default.
- W4224102221 cites W2195333861 @default.
- W4224102221 cites W2275458638 @default.
- W4224102221 cites W2278762463 @default.
- W4224102221 cites W2344003093 @default.
- W4224102221 cites W2521188510 @default.
- W4224102221 cites W2526759556 @default.
- W4224102221 cites W2528474972 @default.
- W4224102221 cites W2553622370 @default.
- W4224102221 cites W2567937106 @default.
- W4224102221 cites W2572678909 @default.
- W4224102221 cites W2585930157 @default.
- W4224102221 cites W2586566675 @default.
- W4224102221 cites W2597612444 @default.
- W4224102221 cites W2723476276 @default.
- W4224102221 cites W2731649509 @default.
- W4224102221 cites W2746731449 @default.
- W4224102221 cites W2765634338 @default.
- W4224102221 cites W2773595117 @default.
- W4224102221 cites W2801641232 @default.
- W4224102221 cites W2883093300 @default.
- W4224102221 cites W2883618327 @default.
- W4224102221 cites W2903981686 @default.
- W4224102221 cites W2915476290 @default.
- W4224102221 cites W2940875293 @default.
- W4224102221 cites W2953073447 @default.
- W4224102221 cites W2960112487 @default.
- W4224102221 cites W2963358881 @default.
- W4224102221 cites W2974316782 @default.
- W4224102221 cites W2979604316 @default.
- W4224102221 cites W2985822937 @default.
- W4224102221 cites W2995968923 @default.
- W4224102221 cites W3000486077 @default.
- W4224102221 cites W3049134750 @default.
- W4224102221 cites W3087166995 @default.
- W4224102221 cites W3118383287 @default.
- W4224102221 cites W3127401245 @default.