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- W4224103617 abstract "Abstract Rapid-eye-movement (REM) sleep is a distinct behavioral state associated with vivid dreaming and memory processing. Phasic bursts of electrical activity, measurable as spike-like pontine (P)-waves, are a hallmark of REM sleep implicated in memory consolidation. However, the brainstem circuits regulating P-waves, and their interactions with circuits generating REM sleep, remain largely unknown. Here, we show that an excitatory population of dorsomedial medulla (dmM) neurons expressing corticotropin-releasing-hormone (CRH) regulates both REM sleep and P-waves. Calcium imaging showed that dmM CRH neurons are selectively activated during REM sleep and recruited during P-waves, and opto- and chemogenetic experiments revealed that this population promotes REM sleep. Chemogenetic manipulation also induced prolonged changes in P-wave frequency, while brief optogenetic activation reliably triggered P-waves along with transiently accelerated theta oscillations in the electroencephalogram (EEG). Together, these findings anatomically and functionally delineate a common medullary hub for the regulation of both REM sleep and P-waves." @default.
- W4224103617 created "2022-04-19" @default.
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- W4224103617 date "2022-04-14" @default.
- W4224103617 modified "2023-09-27" @default.
- W4224103617 title "A medullary hub for controlling REM sleep and pontine waves" @default.
- W4224103617 doi "https://doi.org/10.21203/rs.3.rs-1534766/v1" @default.
- W4224103617 hasPublicationYear "2022" @default.
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