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- W4224126566 startingPage "102372" @default.
- W4224126566 abstract "We investigate the use of confidence scores to evaluate the accuracy of a given AlphaFold (AF2) protein model for drug discovery. Prediction of accuracy is improved by not considering confidence scores below 80 due to the effects of disorder. On a set of recent crystal structures, 95% are likely to have accurate folds. Conformational discordance in the training set has a much more significant effect on accuracy than sequence divergence. We propose criteria for models and residues that are possibly useful for virtual screening. Based on these criteria, AF2 provides models for half of understudied (dark) human proteins and two-thirds of residues in those models." @default.
- W4224126566 created "2022-04-19" @default.
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- W4224126566 date "2022-06-01" @default.
- W4224126566 modified "2023-10-16" @default.
- W4224126566 title "AlphaFold illuminates half of the dark human proteins" @default.
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- W4224126566 doi "https://doi.org/10.1016/j.sbi.2022.102372" @default.
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