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- W4224141671 abstract "Abstract Background: Diabetic kidney disease (DKD) is a common and potentially fatal consequence of diabetes. In the long run, it can lead to chronic renal failure or end-stage renal disease. Many studies have found that gut microorganisms play an important role in maintaining human body homeostasis, and that their metabolites are linked to a variety of chronic disorders, including renal and cardiovascular disease. Methods: We employed 16S rRNA gene sequencing to identify bacteria species in DKD patients and healthy people. Results: The findings indicated that the DKD had a distinct gut microbiota from the HC. Taxonomic investigations indicated that the DKD microbiome had less alpha diversity than a control group. Proteobacteria and Acidobacteria phyla increased in the DKD, while Firmicutes and Bacteroidetes decreased significantly (P<0.05). Acidobacteria and Acidobacteria were the most prevalent microbiota in the DKD, as determined by the LEfSe plot. Changes in the intestinal microbiota of DKD also had an effect on the makeup of metabolites. Short-chain fatty acids (SCFAs) and protein-bound uremic toxins (PBUTs) were shown to be specific. Then we discovered that arginine and proline metabolism was the primary mechanism involved in the regulation of diabetic kidney disease. Conclusions: The findings of this study place the serum and urine microbiota of DKD patients into a functional context and identify the most abundant microbiota (Proteobacteria and Acidobacteria) in DKD. Metabolites of arginine may have a significant impact in people with DKD." @default.
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- W4224141671 date "2022-04-14" @default.
- W4224141671 modified "2023-10-16" @default.
- W4224141671 title "Changes of serum and urine microbiota and metabolite spectrum in patients with diabetic kidney disease" @default.
- W4224141671 doi "https://doi.org/10.21203/rs.3.rs-1543293/v1" @default.
- W4224141671 hasPublicationYear "2022" @default.
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