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- W4224209778 abstract "Asthma disproportionally affects Hispanic and/or Latino backgrounds; however, the relation between circulating metabolites and asthma remains unclear. We conducted a cross-sectional study associating 640 individual serum metabolites, as well as twelve metabolite modules, with asthma in 3347 Hispanic/Latino background participants (514 asthmatics, 15.36%) from the Hispanic/Latino Community Health Study/Study of Latinos. Using survey logistic regression, per standard deviation (SD) increase in 1-arachidonoyl-GPA (20:4) was significantly associated with 32% high odds of asthma after accounting for clinical risk factors (p = 6.27 × 10−5), and per SD of the green module, constructed using weighted gene co-expression network, was suggestively associated with 25% high odds of asthma (p = 0.006). In the stratified analyses by sex and Hispanic and/or Latino backgrounds, the effect of 1-arachidonoyl-GPA (20:4) and the green module was predominantly observed in women (OR = 1.24 and 1.37, p < 0.001) and people of Cuban and Puerto-Rican backgrounds (OR = 1.25 and 1.27, p < 0.01). Mutations in Fatty Acid Desaturase 2 (FADS2) affected the levels of 1-arachidonoyl-GPA (20:4), and Mendelian Randomization analyses revealed that high genetically regulated 1-arachidonoyl-GPA (20:4) levels were associated with increased odds of asthma (p < 0.001). The findings reinforce a molecular basis for asthma etiology, and the potential causal effect of 1-arachidonoyl-GPA (20:4) on asthma provides an opportunity for future intervention." @default.
- W4224209778 created "2022-04-26" @default.
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- W4224209778 date "2022-04-16" @default.
- W4224209778 modified "2023-09-24" @default.
- W4224209778 title "Metabolomic Associations of Asthma in the Hispanic Community Health Study/Study of Latinos" @default.
- W4224209778 cites W1499197514 @default.
- W4224209778 cites W1530739311 @default.
- W4224209778 cites W1935003472 @default.
- W4224209778 cites W1966327575 @default.
- W4224209778 cites W1971802430 @default.
- W4224209778 cites W1972967151 @default.
- W4224209778 cites W1975495566 @default.
- W4224209778 cites W1980270094 @default.
- W4224209778 cites W1989119979 @default.
- W4224209778 cites W2016053764 @default.
- W4224209778 cites W2016867001 @default.
- W4224209778 cites W2017602185 @default.
- W4224209778 cites W2025701648 @default.
- W4224209778 cites W2029565583 @default.
- W4224209778 cites W2034190523 @default.
- W4224209778 cites W2034191690 @default.
- W4224209778 cites W2045052543 @default.
- W4224209778 cites W2055805306 @default.
- W4224209778 cites W2057498577 @default.
- W4224209778 cites W2060705109 @default.
- W4224209778 cites W2068509487 @default.
- W4224209778 cites W2070006909 @default.
- W4224209778 cites W2072355607 @default.
- W4224209778 cites W2073133162 @default.
- W4224209778 cites W2074791308 @default.
- W4224209778 cites W2083370876 @default.
- W4224209778 cites W2110491688 @default.
- W4224209778 cites W2113533986 @default.
- W4224209778 cites W2116404316 @default.
- W4224209778 cites W2123802253 @default.
- W4224209778 cites W2125078269 @default.
- W4224209778 cites W2132611682 @default.
- W4224209778 cites W2133740866 @default.
- W4224209778 cites W2134296519 @default.
- W4224209778 cites W2134983539 @default.
- W4224209778 cites W2139161806 @default.
- W4224209778 cites W2143502368 @default.
- W4224209778 cites W2144748703 @default.
- W4224209778 cites W2145265944 @default.
- W4224209778 cites W2156555691 @default.
- W4224209778 cites W2159268255 @default.
- W4224209778 cites W2166229152 @default.
- W4224209778 cites W2173138167 @default.
- W4224209778 cites W2334426418 @default.
- W4224209778 cites W2539494034 @default.
- W4224209778 cites W2560496194 @default.
- W4224209778 cites W2580916015 @default.
- W4224209778 cites W2585900196 @default.
- W4224209778 cites W2586052295 @default.
- W4224209778 cites W2607572215 @default.
- W4224209778 cites W2730595253 @default.
- W4224209778 cites W2783755930 @default.
- W4224209778 cites W2795126233 @default.
- W4224209778 cites W2806459821 @default.
- W4224209778 cites W2808247948 @default.
- W4224209778 cites W2818417770 @default.
- W4224209778 cites W2890382099 @default.
- W4224209778 cites W2893402095 @default.
- W4224209778 cites W2903796202 @default.
- W4224209778 cites W2904062712 @default.
- W4224209778 cites W2905350932 @default.
- W4224209778 cites W2905701452 @default.
- W4224209778 cites W2908216648 @default.
- W4224209778 cites W2934565342 @default.
- W4224209778 cites W2938581670 @default.
- W4224209778 cites W2951837249 @default.
- W4224209778 cites W2954631498 @default.
- W4224209778 cites W2959042990 @default.
- W4224209778 cites W3003512840 @default.
- W4224209778 cites W3013731050 @default.
- W4224209778 cites W3032731134 @default.
- W4224209778 cites W3033304694 @default.
- W4224209778 cites W3039481699 @default.
- W4224209778 cites W3081479522 @default.
- W4224209778 cites W3091843410 @default.
- W4224209778 cites W3092691896 @default.
- W4224209778 cites W3097226085 @default.
- W4224209778 cites W3110957869 @default.
- W4224209778 cites W3131439703 @default.