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- W4224211798 abstract "Abstract Therapeutic efficacy of steroids on acute respiratory distress syndrome (ARDS) requiring mechanical ventilation (MV) has been reported. However, predictive indicators of early weaning from MV in such cases have not yet been defined. Our aim was to clarify clinical utility of interleukin (IL)-6 level in ventilated patients with established ARDS. Clinical, treatment, and outcome data were evaluated in 119 invasively ventilated patients with ARDS caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Plasma levels of IL-6 and C-reactive protein (CRP) were measured on days 1, 4, and 7 after intubation. Fifty-two patients received dexamethasone (steroid group) and the remaining 67 did not (non-steroid group). Duration of MV use was significantly shorter in the steroid group compared to non-steroid group (11.5±0.6 vs. 16.1±1.0 days, P = 0.0005, respectively). Even when restricted to the steroid group, among the post-MV variables, the IL-6 level on day 7 was most closely correlated with the duration of MV use and showed the highest accuracy for withdrawal from MV within 11 days (AUC: 0.88), with optimal cutoff value of 20.6 pg/mL. Collectively, in intubated patients with ARDS due to SARS-CoV-2 who received dexamethasone, plasma IL-6 levels served as a predictor of early withdrawal from MV." @default.
- W4224211798 created "2022-04-26" @default.
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- W4224211798 date "2022-04-18" @default.
- W4224211798 modified "2023-09-29" @default.
- W4224211798 title "Interleukin-6 as a predictor of early weaning from invasive mechanical ventilation in COVID-19 patients with acute respiratory distress syndrome" @default.
- W4224211798 doi "https://doi.org/10.21203/rs.3.rs-1549232/v1" @default.
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