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• W4224213677 abstract "ABSTRACT Many aquatically respiring animals inhabiting low pH waters can suffer acute inhibition of ion uptake and loss of branchial (gill) epithelial integrity, culminating in a fatal, rapid loss of body Na + . Environmental calcium levels ([Ca 2+ ] e ) are pivotal in maintaining branchial junction integrity, with supplemental Ca 2+ reversing the negative effects of low pH in some animals. Tolerance of some naturally acidic environments by aquatic animals is further complicated by low [Ca 2+ ] e , yet many of these environments are surprisingly biodiverse. How these animals overcome the combined damaging actions of low pH and low environmental Ca 2+ remains unknown. Here, we examined the effects of [Ca 2+ ] e on the response to low pH in larvae of the highly acid tolerant frog Limnodynastes terraereginae . Acute exposure to low pH water in the presence of low [Ca 2+ ] e increased net Na + efflux. Provision of additional [Ca 2+ ] e reduced net Na + efflux, but the effect was saturable. Acclimation to both low and high [Ca 2+ ] e improved the resistance of larvae to Na + efflux at low pH. Inhibition of apical Ca 2+ uptake by ruthenium red resulted in an abrupt loss of tolerance to low pH in larvae acclimated to low pH water. Acclimation to acidic water increased branchial gene expression of the intracellular Ca 2+ transport protein calbindin, consistent with a role for increased transcellular Ca 2+ trafficking in the tolerance of acidic water. This study confirmed the physiological challenge of low [Ca 2+ ] e on branchial integrity in acidic waters and highlighted a potential role for maintenance of transcellular Ca 2+ uptake in the acid tolerance of L. terraereginae . Summary statement Tolerance of naturally acidic, dilute, and soft waters by larvae of the frog Limnodynastes terraereginae involves adaptations to the branchial calcium transport pathway which protects intercellular junctions against damage." @default.
• W4224213677 created "2022-04-26" @default.
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• W4224213677 date "2022-04-19" @default.
• W4224213677 modified "2023-09-24" @default.
• W4224213677 title "The role of environmental calcium in the extreme acid tolerance of northern banjo frog (<i>Limnodynastes terraereginae</i>) larvae" @default.
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• W4224213677 doi "https://doi.org/10.1101/2022.04.18.488693" @default.
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