Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224217213> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4224217213 endingPage "2278" @default.
- W4224217213 startingPage "2259" @default.
- W4224217213 abstract "This study aims to develop a risk prediction model of pyroptosis-related genes based on its impact on immunotherapy sensitivity of uterine corpus endometrial carcinoma (UCEC), one of the most common and threatening gynecological malignancies.Through multiple bioinformatics analysis, we obtained raw counts of RNA-sequencing data and corresponding clinical information related to UCEC from The Cancer Genome Atlas (TCGA) and Gene Expression Profiling Interactive Analysis (GEPIA) to investigate the potential mechanisms of differentially expressed pyroptosis-related genes (DEPRGs), including the correlation between DEPRGs and prognosis, tumor immune microenvironment and the immunotherapy sensitivity of UCEC patients. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) Enrichment Analysis were used to figure out the functional differences. Furthermore, a mRNA-miRNA-lncRNA network was constructed to identify potential impact of pyroptosis on tumor progression.In this study, we achieved six DEPRGs (CASP3, GPX4, GSDMD, NOD2, PYCARD and TIRAP) and constructed a 6-gene signature which classified UCEC patients in the TCGA cohort into a low-risk group or a high-risk group. Patients in the low-risk group showed significantly longer survival time (p=0.000373). The risk score was also confirmed as an independent prognostic factor combining with the clinical characteristics. GO and KEGG functional analysis revealed the possible molecular mechanisms by which six DEPRGs influence anti-tumor immunity in UCEC patients. In addition, we found that two DEPRGs (GPX4, TIRAP) were not only significantly associated with tumor mutational burden (TMB) or microsatellite Instability (MSI), but also involved in regulating the number and function of CD8+ cells.Upon comprehensive bioinformatics analysis, it was concluded that pyroptosis-related genes (PRGs) could predict the prognosis of EC patients and be affected in modulating the anti-tumor immune responses for patients with EC." @default.
- W4224217213 created "2022-04-26" @default.
- W4224217213 creator A5019197729 @default.
- W4224217213 creator A5049695949 @default.
- W4224217213 date "2022-04-01" @default.
- W4224217213 modified "2023-09-29" @default.
- W4224217213 title "A novel risk prediction model of pyroptosis-related genes for the prognosis and immunotherapy response of endometrial cancer." @default.
- W4224217213 doi "https://doi.org/10.26355/eurrev_202204_28456" @default.
- W4224217213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35442481" @default.
- W4224217213 hasPublicationYear "2022" @default.
- W4224217213 type Work @default.
- W4224217213 citedByCount "1" @default.
- W4224217213 countsByYear W42242172132022 @default.
- W4224217213 crossrefType "journal-article" @default.
- W4224217213 hasAuthorship W4224217213A5019197729 @default.
- W4224217213 hasAuthorship W4224217213A5049695949 @default.
- W4224217213 hasConcept C104317684 @default.
- W4224217213 hasConcept C121608353 @default.
- W4224217213 hasConcept C126322002 @default.
- W4224217213 hasConcept C143998085 @default.
- W4224217213 hasConcept C150194340 @default.
- W4224217213 hasConcept C152724338 @default.
- W4224217213 hasConcept C162317418 @default.
- W4224217213 hasConcept C17172800 @default.
- W4224217213 hasConcept C203014093 @default.
- W4224217213 hasConcept C2776914184 @default.
- W4224217213 hasConcept C2777088508 @default.
- W4224217213 hasConcept C2777209026 @default.
- W4224217213 hasConcept C2777701055 @default.
- W4224217213 hasConcept C502942594 @default.
- W4224217213 hasConcept C54355233 @default.
- W4224217213 hasConcept C60644358 @default.
- W4224217213 hasConcept C70721500 @default.
- W4224217213 hasConcept C71924100 @default.
- W4224217213 hasConcept C86803240 @default.
- W4224217213 hasConcept C8891405 @default.
- W4224217213 hasConceptScore W4224217213C104317684 @default.
- W4224217213 hasConceptScore W4224217213C121608353 @default.
- W4224217213 hasConceptScore W4224217213C126322002 @default.
- W4224217213 hasConceptScore W4224217213C143998085 @default.
- W4224217213 hasConceptScore W4224217213C150194340 @default.
- W4224217213 hasConceptScore W4224217213C152724338 @default.
- W4224217213 hasConceptScore W4224217213C162317418 @default.
- W4224217213 hasConceptScore W4224217213C17172800 @default.
- W4224217213 hasConceptScore W4224217213C203014093 @default.
- W4224217213 hasConceptScore W4224217213C2776914184 @default.
- W4224217213 hasConceptScore W4224217213C2777088508 @default.
- W4224217213 hasConceptScore W4224217213C2777209026 @default.
- W4224217213 hasConceptScore W4224217213C2777701055 @default.
- W4224217213 hasConceptScore W4224217213C502942594 @default.
- W4224217213 hasConceptScore W4224217213C54355233 @default.
- W4224217213 hasConceptScore W4224217213C60644358 @default.
- W4224217213 hasConceptScore W4224217213C70721500 @default.
- W4224217213 hasConceptScore W4224217213C71924100 @default.
- W4224217213 hasConceptScore W4224217213C86803240 @default.
- W4224217213 hasConceptScore W4224217213C8891405 @default.
- W4224217213 hasIssue "7" @default.
- W4224217213 hasLocation W42242172131 @default.
- W4224217213 hasOpenAccess W4224217213 @default.
- W4224217213 hasPrimaryLocation W42242172131 @default.
- W4224217213 hasRelatedWork W10925770 @default.
- W4224217213 hasRelatedWork W11262281 @default.
- W4224217213 hasRelatedWork W11877863 @default.
- W4224217213 hasRelatedWork W3073281 @default.
- W4224217213 hasRelatedWork W4530863 @default.
- W4224217213 hasRelatedWork W6346941 @default.
- W4224217213 hasRelatedWork W6444463 @default.
- W4224217213 hasRelatedWork W7323818 @default.
- W4224217213 hasRelatedWork W8859235 @default.
- W4224217213 hasRelatedWork W9795451 @default.
- W4224217213 hasVolume "26" @default.
- W4224217213 isParatext "false" @default.
- W4224217213 isRetracted "false" @default.
- W4224217213 workType "article" @default.