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• W4224221479 abstract "Reduced blood flow velocity in the vein triggers inflammation and is associated with the release into the extracellular space of alarmins or damage-associated molecular patterns (DAMPs). These molecules include extracellular nucleic acids, extracellular purinergic nucleotides (ATP, ADP), cytokines and extracellular HMGB1. They are recognized as a danger signal by immune cells, platelets and endothelial cells. Hence, endothelial cells are capable of sensing environmental cues through a wide variety of receptors expressed at the plasma membrane. The endothelium is then responding by expressing pro-coagulant proteins, including tissue factor, and inflammatory molecules such as cytokines and chemokines involved in the recruitment and activation of platelets and leukocytes. This ultimately leads to thrombosis, which is an active pro-inflammatory process, tightly regulated, that needs to be properly resolved to avoid further vascular damages. These mechanisms are often dysregulated, which promote fibrinolysis defects, activation of the immune system and irreversible vascular damages further contributing to thrombotic and inflammatory processes. The concept of thrombo-inflammation is now widely used to describe the complex interactions between the coagulation and inflammation in various cardiovascular diseases. In endothelial cells, activating signals converge to multiple intracellular pathways leading to phenotypical changes turning them into inflammatory-like cells. Accumulating evidence suggest that endothelial to mesenchymal transition (EndMT) may be a major mechanism of endothelial dysfunction induced during inflammation and thrombosis. EndMT is a biological process where endothelial cells lose their endothelial characteristics and acquire mesenchymal markers and functions. Endothelial dysfunction might play a central role in orchestrating and amplifying thrombo-inflammation thought induction of EndMT processes. Mechanisms regulating endothelial dysfunction have been only partially uncovered in the context of thrombotic diseases. In the present review, we focus on the importance of the endothelial phenotype and discuss how endothelial plasticity may regulate the interplay between thrombosis and inflammation. We discuss how the endothelial cells are sensing and responding to environmental cues and contribute to thrombo-inflammation with a particular focus on venous thromboembolism (VTE). A better understanding of the precise mechanisms involved and the specific role of endothelial cells is needed to characterize VTE incidence and address the risk of recurrent VTE and its sequelae." @default.
• W4224221479 created "2022-04-26" @default.
• W4224221479 creator A5001583684 @default.
• W4224221479 creator A5003179423 @default.
• W4224221479 creator A5006624248 @default.
• W4224221479 creator A5016569236 @default.
• W4224221479 creator A5045010479 @default.
• W4224221479 date "2022-04-21" @default.
• W4224221479 modified "2023-10-05" @default.
• W4224221479 title "Endothelial Cell Phenotype, a Major Determinant of Venous Thrombo-Inflammation" @default.
• W4224221479 cites W1861205220 @default.
• W4224221479 cites W1875758676 @default.
• W4224221479 cites W1948854550 @default.
• W4224221479 cites W1963536396 @default.
• W4224221479 cites W1994749414 @default.
• W4224221479 cites W1998209552 @default.
• W4224221479 cites W2005888993 @default.
• W4224221479 cites W2006296021 @default.
• W4224221479 cites W2006705030 @default.
• W4224221479 cites W2014482578 @default.
• W4224221479 cites W2023213297 @default.
• W4224221479 cites W2025898860 @default.
• W4224221479 cites W2028294482 @default.
• W4224221479 cites W2042851093 @default.
• W4224221479 cites W2045220907 @default.
• W4224221479 cites W2049029258 @default.
• W4224221479 cites W2058172582 @default.
• W4224221479 cites W2059217150 @default.
• W4224221479 cites W2064369146 @default.
• W4224221479 cites W2064961205 @default.
• W4224221479 cites W2068718445 @default.
• W4224221479 cites W2073698342 @default.
• W4224221479 cites W2074536446 @default.
• W4224221479 cites W2078817520 @default.
• W4224221479 cites W2082851543 @default.
• W4224221479 cites W2089812396 @default.
• W4224221479 cites W2093313289 @default.
• W4224221479 cites W2111925820 @default.
• W4224221479 cites W2114880343 @default.
• W4224221479 cites W2119129191 @default.
• W4224221479 cites W2119250965 @default.
• W4224221479 cites W2123789360 @default.
• W4224221479 cites W2125089384 @default.
• W4224221479 cites W2130275173 @default.
• W4224221479 cites W2131359296 @default.
• W4224221479 cites W2147266392 @default.
• W4224221479 cites W2147304052 @default.
• W4224221479 cites W2149810777 @default.
• W4224221479 cites W2150184837 @default.
• W4224221479 cites W2157827945 @default.
• W4224221479 cites W2158289906 @default.
• W4224221479 cites W2170640128 @default.
• W4224221479 cites W2172191543 @default.
• W4224221479 cites W2205449455 @default.
• W4224221479 cites W2254408877 @default.
• W4224221479 cites W2294236942 @default.
• W4224221479 cites W2320753854 @default.
• W4224221479 cites W2342098014 @default.
• W4224221479 cites W2404731296 @default.
• W4224221479 cites W2462416197 @default.
• W4224221479 cites W2508261355 @default.
• W4224221479 cites W2529135210 @default.
• W4224221479 cites W2572149156 @default.
• W4224221479 cites W2581605534 @default.
• W4224221479 cites W2584442474 @default.
• W4224221479 cites W2587625705 @default.
• W4224221479 cites W2595348957 @default.
• W4224221479 cites W2598418190 @default.
• W4224221479 cites W2604432328 @default.
• W4224221479 cites W2605773822 @default.
• W4224221479 cites W2609290389 @default.
• W4224221479 cites W2612661993 @default.
• W4224221479 cites W2621371007 @default.
• W4224221479 cites W2748400555 @default.
• W4224221479 cites W2762816177 @default.
• W4224221479 cites W2766752424 @default.
• W4224221479 cites W2767779948 @default.
• W4224221479 cites W2768623326 @default.
• W4224221479 cites W2769886493 @default.
• W4224221479 cites W2770666183 @default.
• W4224221479 cites W2781793836 @default.
• W4224221479 cites W2792578653 @default.
• W4224221479 cites W2793749910 @default.
• W4224221479 cites W2801096113 @default.
• W4224221479 cites W2805927967 @default.
• W4224221479 cites W2807578948 @default.
• W4224221479 cites W2891810721 @default.
• W4224221479 cites W2898651160 @default.
• W4224221479 cites W2908872367 @default.
• W4224221479 cites W2908974911 @default.
• W4224221479 cites W2911093128 @default.
• W4224221479 cites W2915578859 @default.
• W4224221479 cites W2920595339 @default.
• W4224221479 cites W2921140416 @default.
• W4224221479 cites W2936366881 @default.
• W4224221479 cites W2944725083 @default.
• W4224221479 cites W2958075692 @default.
• W4224221479 cites W2958949175 @default.
• W4224221479 cites W2970727076 @default.
• W4224221479 cites W2972400204 @default.

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