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- W4224222575 abstract "Recent advances in the technology of producing novel cardiomyocytes from induced pluripotent stem cells (iPSC-cardiomyocytes) fuel new hope for future clinical applications. The use of iPSC-cardiomyocytes is particularly promising for the therapy of cardiac diseases such as myocardial infarction, where these cells could replace scar tissue and restore the functionality of the heart. Despite successful cardiogenic differentiation, medical applications of iPSC-cardiomyocytes are currently limited by their pronounced immature structural and functional phenotype. This review focuses on gap junction function in iPSC-cardiomyocytes and portrays our current understanding around the structural and the functional limitations of intercellular coupling and viable cardiac graft formation involving these novel cardiac muscle cells. We further highlight the role of the gap junction protein connexin 43 as a potential target for improving cell-cell communication and electrical signal propagation across cardiac tissue engineered from iPSC-cardiomyocytes. Better insight into the mechanisms that promote functional intercellular coupling is the foundation that will allow the development of novel strategies to combat the immaturity of iPSC-cardiomyocytes and pave the way toward cardiac tissue regeneration." @default.
- W4224222575 created "2022-04-26" @default.
- W4224222575 creator A5029142511 @default.
- W4224222575 creator A5044892124 @default.
- W4224222575 creator A5052077043 @default.
- W4224222575 creator A5078496774 @default.
- W4224222575 creator A5091729598 @default.
- W4224222575 date "2022-04-18" @default.
- W4224222575 modified "2023-10-01" @default.
- W4224222575 title "The Structural and the Functional Aspects of Intercellular Communication in iPSC-Cardiomyocytes" @default.
- W4224222575 cites W1549853423 @default.
- W4224222575 cites W1631250427 @default.
- W4224222575 cites W1790601077 @default.
- W4224222575 cites W1830028488 @default.
- W4224222575 cites W1907511822 @default.
- W4224222575 cites W1950518418 @default.
- W4224222575 cites W1963100239 @default.
- W4224222575 cites W1965380680 @default.
- W4224222575 cites W1971321550 @default.
- W4224222575 cites W1972730332 @default.
- W4224222575 cites W1976828210 @default.
- W4224222575 cites W1981531825 @default.
- W4224222575 cites W1983612345 @default.
- W4224222575 cites W1984996259 @default.
- W4224222575 cites W1987594610 @default.
- W4224222575 cites W1994144781 @default.
- W4224222575 cites W1994170225 @default.
- W4224222575 cites W1994524954 @default.
- W4224222575 cites W2000137341 @default.
- W4224222575 cites W2001535302 @default.
- W4224222575 cites W2015441385 @default.
- W4224222575 cites W2015487546 @default.
- W4224222575 cites W2023240247 @default.
- W4224222575 cites W2023315677 @default.
- W4224222575 cites W2026268864 @default.
- W4224222575 cites W2028036560 @default.
- W4224222575 cites W2031025602 @default.
- W4224222575 cites W2035312069 @default.
- W4224222575 cites W2035512665 @default.
- W4224222575 cites W2037260153 @default.
- W4224222575 cites W2037769177 @default.
- W4224222575 cites W2040247477 @default.
- W4224222575 cites W2040850663 @default.
- W4224222575 cites W2041171500 @default.
- W4224222575 cites W2045899482 @default.
- W4224222575 cites W2055163653 @default.
- W4224222575 cites W2060868528 @default.
- W4224222575 cites W2061778565 @default.
- W4224222575 cites W2064467597 @default.
- W4224222575 cites W2067796383 @default.
- W4224222575 cites W2070769557 @default.
- W4224222575 cites W2071769628 @default.
- W4224222575 cites W2072426899 @default.
- W4224222575 cites W2073072215 @default.
- W4224222575 cites W2076452380 @default.
- W4224222575 cites W2077806591 @default.
- W4224222575 cites W2079298482 @default.
- W4224222575 cites W2079592630 @default.
- W4224222575 cites W2081081246 @default.
- W4224222575 cites W2081906155 @default.
- W4224222575 cites W2086294280 @default.
- W4224222575 cites W2090043621 @default.
- W4224222575 cites W2091013332 @default.
- W4224222575 cites W2092922521 @default.
- W4224222575 cites W2101719573 @default.
- W4224222575 cites W2102019826 @default.
- W4224222575 cites W2104838758 @default.
- W4224222575 cites W2111355903 @default.
- W4224222575 cites W2119146359 @default.
- W4224222575 cites W2125951597 @default.
- W4224222575 cites W2127410615 @default.
- W4224222575 cites W2130004022 @default.
- W4224222575 cites W2130422445 @default.
- W4224222575 cites W2135662719 @default.
- W4224222575 cites W2137820120 @default.
- W4224222575 cites W2138977668 @default.
- W4224222575 cites W2147611167 @default.
- W4224222575 cites W2148220540 @default.
- W4224222575 cites W2152793450 @default.
- W4224222575 cites W2154148336 @default.
- W4224222575 cites W2155347215 @default.
- W4224222575 cites W2159873771 @default.
- W4224222575 cites W2161194374 @default.
- W4224222575 cites W2164152961 @default.
- W4224222575 cites W2166305181 @default.
- W4224222575 cites W2198099087 @default.
- W4224222575 cites W2510668402 @default.
- W4224222575 cites W2521650734 @default.
- W4224222575 cites W2528173482 @default.
- W4224222575 cites W2563980205 @default.
- W4224222575 cites W2570852555 @default.
- W4224222575 cites W2575334072 @default.
- W4224222575 cites W2581076299 @default.
- W4224222575 cites W2611097488 @default.
- W4224222575 cites W2613801161 @default.
- W4224222575 cites W2613975174 @default.
- W4224222575 cites W2650764617 @default.
- W4224222575 cites W2745770472 @default.