Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224222755> ?p ?o ?g. }
- W4224222755 endingPage "2055" @default.
- W4224222755 startingPage "2055" @default.
- W4224222755 abstract "Signaling pathways involving signal transducer and activator of transcription 3 (STAT3) play key roles in the aggressiveness of pancreatic ductal adenocarcinoma (PDAC), including their tumorigenesis, invasion, and metastasis. Cancer stem cells (CSCs) have been correlated with PDAC aggressiveness, and activation of STAT3 is involved in the regulation of CSC properties. Here, we investigated the involvement of interleukin-6 (IL-6) or the leukemia inhibitory factor (LIF)/glycoprotein 130 (gp130)/STAT3 pathway and their role in pancreatic CSCs. In PDAC CSC-like cells formed by culturing on a low attachment plate, autocrine/paracrine IL-6 or LIF contributes to gp130/STAT3 pathway activation. Using a gp130 inhibitor, we determined that the gp130/STAT3 pathway contributes to the maintenance of stemness features, the expression of membrane-type 1 matrix metalloproteinase (MT1-MMP), and the invasion of PDAC CSC-like cells. The gp130/STAT3 pathway also modulates the transforming growth factor (TGF)-β1/Smad pathway required for epithelial-mesenchymal transition induction through regulation of TGFβ-RII expression in PDAC CSC-like cells. Furthermore, chromatin immunoprecipitation assays revealed that p-STAT3 can access the active promoter region of H19 to influence this metastasis-related long non-coding RNA and contribute to its transcription in PDAC CSC-like cells. Therefore, the autocrine/paracrine IL-6 or LIF/gp130/STAT3 pathway in PDAC CSC-like cells may eventually facilitate invasion and metastasis, two hallmarks of malignancy. We propose that inhibition of the gp130/STAT3 pathway provides a promising strategy for targeting CSCs for the treatment of PDAC." @default.
- W4224222755 created "2022-04-26" @default.
- W4224222755 creator A5001352072 @default.
- W4224222755 creator A5011169770 @default.
- W4224222755 creator A5014787780 @default.
- W4224222755 creator A5027281595 @default.
- W4224222755 creator A5064449087 @default.
- W4224222755 creator A5065566375 @default.
- W4224222755 creator A5069820503 @default.
- W4224222755 creator A5087653357 @default.
- W4224222755 date "2022-04-19" @default.
- W4224222755 modified "2023-10-03" @default.
- W4224222755 title "Gp130-Mediated STAT3 Activation Contributes to the Aggressiveness of Pancreatic Cancer through H19 Long Non-Coding RNA Expression" @default.
- W4224222755 cites W1779691448 @default.
- W4224222755 cites W1858549592 @default.
- W4224222755 cites W1931245889 @default.
- W4224222755 cites W1942105196 @default.
- W4224222755 cites W1948215485 @default.
- W4224222755 cites W1965498876 @default.
- W4224222755 cites W1968812902 @default.
- W4224222755 cites W1973237961 @default.
- W4224222755 cites W1976076317 @default.
- W4224222755 cites W1978845460 @default.
- W4224222755 cites W1980339030 @default.
- W4224222755 cites W1985648424 @default.
- W4224222755 cites W1990895545 @default.
- W4224222755 cites W1995778320 @default.
- W4224222755 cites W2000999796 @default.
- W4224222755 cites W2010443860 @default.
- W4224222755 cites W2014019546 @default.
- W4224222755 cites W2015036988 @default.
- W4224222755 cites W2015331193 @default.
- W4224222755 cites W2025252202 @default.
- W4224222755 cites W2028205153 @default.
- W4224222755 cites W2029443168 @default.
- W4224222755 cites W2059182166 @default.
- W4224222755 cites W2062837746 @default.
- W4224222755 cites W2078552560 @default.
- W4224222755 cites W2079210988 @default.
- W4224222755 cites W2079908422 @default.
- W4224222755 cites W2081165140 @default.
- W4224222755 cites W2086968193 @default.
- W4224222755 cites W2087768671 @default.
- W4224222755 cites W2089733360 @default.
- W4224222755 cites W2089990689 @default.
- W4224222755 cites W2091245777 @default.
- W4224222755 cites W2096649955 @default.
- W4224222755 cites W2098158603 @default.
- W4224222755 cites W2111997581 @default.
- W4224222755 cites W2130543801 @default.
- W4224222755 cites W2131170195 @default.
- W4224222755 cites W2132444060 @default.
- W4224222755 cites W2133591242 @default.
- W4224222755 cites W2136928950 @default.
- W4224222755 cites W2147689539 @default.
- W4224222755 cites W2150158318 @default.
- W4224222755 cites W2153086428 @default.
- W4224222755 cites W2153450196 @default.
- W4224222755 cites W2154790710 @default.
- W4224222755 cites W2155968567 @default.
- W4224222755 cites W2169895148 @default.
- W4224222755 cites W2190442201 @default.
- W4224222755 cites W2406603261 @default.
- W4224222755 cites W2460494782 @default.
- W4224222755 cites W2469675330 @default.
- W4224222755 cites W2510632936 @default.
- W4224222755 cites W2520133312 @default.
- W4224222755 cites W2570584539 @default.
- W4224222755 cites W2590390825 @default.
- W4224222755 cites W2614509690 @default.
- W4224222755 cites W2736952847 @default.
- W4224222755 cites W2757308519 @default.
- W4224222755 cites W2768116183 @default.
- W4224222755 cites W2771801871 @default.
- W4224222755 cites W2784570320 @default.
- W4224222755 cites W2790578421 @default.
- W4224222755 cites W2792680065 @default.
- W4224222755 cites W2793892355 @default.
- W4224222755 cites W2794963458 @default.
- W4224222755 cites W2795293874 @default.
- W4224222755 cites W2799532497 @default.
- W4224222755 cites W2799869370 @default.
- W4224222755 cites W2804717104 @default.
- W4224222755 cites W2805940849 @default.
- W4224222755 cites W2806281670 @default.
- W4224222755 cites W2895274909 @default.
- W4224222755 cites W2900310474 @default.
- W4224222755 cites W2905568751 @default.
- W4224222755 cites W2912414429 @default.
- W4224222755 cites W2921144486 @default.
- W4224222755 cites W2941033607 @default.
- W4224222755 cites W2945750405 @default.
- W4224222755 cites W2955337084 @default.
- W4224222755 cites W2961842639 @default.
- W4224222755 cites W2966100245 @default.
- W4224222755 cites W2981124016 @default.
- W4224222755 cites W2985813527 @default.
- W4224222755 cites W2998678190 @default.