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• W4224228678 abstract "Cellular components are non-randomly arranged with respect to the shape and polarity of the whole cell.1Frankel J. Pattern formation: ciliate studies and models.Science. 1989; 248 (1524): 1562Google Scholar, 2Kirschner M. Gerhart J. Mitchison T. Molecular “vitalism”. Cell. 2000; 100: 79-88Scopus (158) Google Scholar, 3Harold F.M. Molecules into cells: specifying spatial architecture.Microbiol. Mol. Biol. Rev. 2005; 69: 544-564Crossref PubMed Scopus (116) Google Scholar, 4Marshall W.F. Origins of cellular geometry.BMC Biol. 2011; 9: 1-9Crossref PubMed Scopus (32) Google Scholar Patterning within cells can extend down to the level of individual proteins and mRNA.5Shulman J.M. St Johnston D. Pattern formation in single cells.Trends Cell Biol. 1999; 9: M60-M64Abstract Full Text Full Text PDF PubMed Scopus (21) Google Scholar,6Das S. Vera M. Gandin V. Singer R.H. Tutucci E. Intracellular mRNA transport and localized translation.Nat. Rev. Mol. Cell Biol. 2021; 22: 483-504Crossref PubMed Scopus (26) Google Scholar But how much of the proteome is actually localized with respect to cell polarity axes? Proteomics combined with cellular fractionation7Foster L.J. de Hoog C.L. Zhang Y. Zhang Y. Xie X. Mootha V.K. Mann M. A mammalian organelle map by protein correlation profiling.Cell. 2006; 125: 187-199Abstract Full Text Full Text PDF PubMed Scopus (464) Google Scholar, 8Dunkley T.P.J. Hester S. Shadforth I.P. Runions J. Weimar T. Hanton S.L. Griffin J.L. Bessant C. Brandizzi F. Hawes C. et al.Mapping the Arabidopsis organelle proteome.Proc. Natl. Acad. Sci. USA. 2006; 103: 6518-6523Crossref PubMed Scopus (431) Google Scholar, 9Wühr M. Güttler T. Peshkin L. McAlister G.C. Sonnett M. Ishihara K. Groen A.C. Presler M. Erickson B.K. Mitchison T.J. et al.The nuclear proteome of a vertebrate.Curr. Biol. 2015; 25: 2663-2671Abstract Full Text Full Text PDF PubMed Scopus (87) Google Scholar, 10Itzhak D.N. Tyanova S. Cox J. Borner G.H. Global, quantitative and dynamic mapping of protein subcellular localization.eLife. 2016; 5: e16950Crossref PubMed Scopus (278) Google Scholar, 11Pandya N.J. Koopmans F. Slotman J.A. Paliukhovich I. Houtsmuller A.B. Smit A.B. Li K.W. Correlation profiling of brain sub-cellular proteomes reveals co-assembly of synaptic proteins and subcellular distribution.Sci. Rep. 2017; 7: 12107Crossref PubMed Scopus (26) Google Scholar has shown that most proteins localize to one or more organelles but does not tell us how many proteins have a polarized localization with respect to the large-scale polarity axes of the intact cell. Genome-wide localization studies in yeast12Kumar A. Agarwal S. Heyman J.A. Matson S. Heidtman M. Piccirillo S. Umansky L. Drawid A. Jansen R. Liu Y. et al.Subcellular localization of the yeast proteome.Genes Dev. 2002; 16: 707-719Crossref PubMed Scopus (635) Google Scholar, 13Huh W.K. Falvo J.V. Gerke L.C. Carroll A.S. Howson R.W. Weissman J.S. O'Shea E.K. Global analysis of protein localization in budding yeast.Nature. 2003; 425: 686-691Crossref PubMed Scopus (3234) Google Scholar, 14Narayanaswamy R. Moradi E.K. Niu W. Hart G.T. Davis M. McGary K.L. Ellington A.D. Marcotte E.M. Systematic definition of protein constituents along the major polarization axis reveals an adaptive reuse of the polarization machinery in pheromone-treated budding yeast.J. Proteome Res. 2009; 8: 6-19Crossref PubMed Scopus (25) Google Scholar, 15Chong Y.T. Koh J.L. Friesen H. Duffy S.K. Cox M.J. Moses A. Moffat J. Boone C. Andrews B.J. Yeast proteome dynamics from single cell imaging and automated analysis.Cell. 2015; 161: 1413-1424Abstract Full Text Full Text PDF PubMed Scopus (175) Google Scholar found that only a few percent of proteins have a localized position relative to the cell polarity axis defined by sites of polarized cell growth. Here, we describe an approach for analyzing protein distribution within a cell with a visibly obvious global patterning—the giant ciliate Stentor coeruleus.16Tartar V. The Biology of Stentor. Pergamon Press, 1961Crossref Google Scholar,17Marshall W.F. Regeneration in Stentor coeruleus.Front. Cell Dev. Biol. 2021; 9: 753625Crossref PubMed Scopus (3) Google Scholar Ciliates, including Stentor, have highly polarized cell shapes with visible surface patterning.1Frankel J. Pattern formation: ciliate studies and models.Science. 1989; 248 (1524): 1562Google Scholar,18Aufderheide K.J. Frankel J. Williams N.E. Formation and positioning of surface-related structures in protozoa.Microbiol. Rev. 1980; 44: 252-302Crossref PubMed Google Scholar A Stentor cell is roughly 2 mm long, allowing a “proteomic dissection” in which microsurgery is used to separate cellular fragments along the anterior-posterior axis, followed by comparative proteomic analysis. In our analysis, 25% of the proteome, including signaling proteins, centrin/SFI proteins, and GAS2 orthologs, shows a polarized location along the cell’s anterior-posterior axis. We conclude that a large proportion of all proteins are polarized with respect to global cell polarity axes and that proteomic dissection provides a simple and effective approach for spatial proteomics." @default.
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• W4224228678 date "2022-05-01" @default.
• W4224228678 modified "2023-09-25" @default.
• W4224228678 title "Determining protein polarization proteome-wide using physical dissection of individual Stentor coeruleus cells" @default.
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• W4224228678 doi "https://doi.org/10.1016/j.cub.2022.03.078" @default.
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