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- W4224229019 endingPage "593" @default.
- W4224229019 startingPage "593" @default.
- W4224229019 abstract "Asthma is a disease with high incidence and prevalence, and its severe form accounts for approximately 10% of asthmatics. Over the last decade, the increasing knowledge of the mechanisms underlying the disease allowed the development of biological drugs capable of sufficiently controlling symptoms and reducing the use of systemic steroids. The best-known mechanisms are those pertaining to type 2 inflammation, for which drugs were developed and studied. Those biological treatments affect crucial points of bronchial inflammation. Among the mechanisms explored, there were IgE (Omalizumab), interleukin 5 (Mepolizumab and Reslizumab), interleukin 5 receptor alpha (Benralizumab) and interleukin 4/13 receptor (Dupilumab). Under investigation and expected to be soon commercialized is the monoclonal antibody blocking the thymic stromal lymphopoietin (Tezepelumab). Seemingly under study and promising, are anti-interleukin-33 (itepekimab) and anti-suppressor of tumorigenicity-2 (astegolimab). With this study, we want to provide an overview of these drugs, paying particular attention to their mechanism of action, the main endpoints reached in clinical trials, the main results obtained in real life and some unclear points regarding their usage." @default.
- W4224229019 created "2022-04-26" @default.
- W4224229019 creator A5016801522 @default.
- W4224229019 creator A5061055798 @default.
- W4224229019 creator A5061532803 @default.
- W4224229019 creator A5064139659 @default.
- W4224229019 creator A5070530802 @default.
- W4224229019 creator A5073839386 @default.
- W4224229019 creator A5078979960 @default.
- W4224229019 creator A5080326198 @default.
- W4224229019 date "2022-04-07" @default.
- W4224229019 modified "2023-10-18" @default.
- W4224229019 title "Specific Therapy for T2 Asthma" @default.
- W4224229019 cites W1885435857 @default.
- W4224229019 cites W1947232527 @default.
- W4224229019 cites W1967215794 @default.
- W4224229019 cites W1970648068 @default.
- W4224229019 cites W1989121912 @default.
- W4224229019 cites W2002980147 @default.
- W4224229019 cites W2021701428 @default.
- W4224229019 cites W2029587541 @default.
- W4224229019 cites W2039930386 @default.
- W4224229019 cites W2065797637 @default.
- W4224229019 cites W2075699130 @default.
- W4224229019 cites W2095754126 @default.
- W4224229019 cites W2098276532 @default.
- W4224229019 cites W2105880697 @default.
- W4224229019 cites W2110052844 @default.
- W4224229019 cites W2121954044 @default.
- W4224229019 cites W2138355864 @default.
- W4224229019 cites W2200308911 @default.
- W4224229019 cites W2299773175 @default.
- W4224229019 cites W2309688181 @default.
- W4224229019 cites W2342693354 @default.
- W4224229019 cites W2511120040 @default.
- W4224229019 cites W2513258422 @default.
- W4224229019 cites W2515998798 @default.
- W4224229019 cites W2546570192 @default.
- W4224229019 cites W2548196387 @default.
- W4224229019 cites W2562179046 @default.
- W4224229019 cites W2591683849 @default.
- W4224229019 cites W2600504827 @default.
- W4224229019 cites W2604165347 @default.
- W4224229019 cites W2604291894 @default.
- W4224229019 cites W2728825901 @default.
- W4224229019 cites W2767294221 @default.
- W4224229019 cites W2802210588 @default.
- W4224229019 cites W2802621594 @default.
- W4224229019 cites W2803625106 @default.
- W4224229019 cites W2803941918 @default.
- W4224229019 cites W2885029018 @default.
- W4224229019 cites W2892016825 @default.
- W4224229019 cites W2892058094 @default.
- W4224229019 cites W2896299453 @default.
- W4224229019 cites W2896766242 @default.
- W4224229019 cites W2899827635 @default.
- W4224229019 cites W2907222399 @default.
- W4224229019 cites W2913857631 @default.
- W4224229019 cites W2933691417 @default.
- W4224229019 cites W2947050213 @default.
- W4224229019 cites W2949031258 @default.
- W4224229019 cites W2954697371 @default.
- W4224229019 cites W2961369024 @default.
- W4224229019 cites W2961843065 @default.
- W4224229019 cites W2969485794 @default.
- W4224229019 cites W2971202673 @default.
- W4224229019 cites W2973437633 @default.
- W4224229019 cites W2987452586 @default.
- W4224229019 cites W2998555888 @default.
- W4224229019 cites W2999696063 @default.
- W4224229019 cites W3002274027 @default.
- W4224229019 cites W3002455096 @default.
- W4224229019 cites W3004838051 @default.
- W4224229019 cites W3006151863 @default.
- W4224229019 cites W3007780891 @default.
- W4224229019 cites W3015924558 @default.
- W4224229019 cites W3021383992 @default.
- W4224229019 cites W3030200031 @default.
- W4224229019 cites W3037468357 @default.
- W4224229019 cites W3038134106 @default.
- W4224229019 cites W3038486779 @default.
- W4224229019 cites W3049165135 @default.
- W4224229019 cites W3082062213 @default.
- W4224229019 cites W3087407993 @default.
- W4224229019 cites W3090269684 @default.
- W4224229019 cites W3093042321 @default.
- W4224229019 cites W3096835187 @default.
- W4224229019 cites W3123025817 @default.
- W4224229019 cites W3135312017 @default.
- W4224229019 cites W3152867209 @default.
- W4224229019 cites W3152988358 @default.
- W4224229019 cites W3156313915 @default.
- W4224229019 cites W3162024685 @default.
- W4224229019 cites W3163970761 @default.
- W4224229019 cites W3176401948 @default.
- W4224229019 cites W3180672846 @default.
- W4224229019 cites W3187490622 @default.
- W4224229019 cites W3198828656 @default.