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- W4224230881 endingPage "482" @default.
- W4224230881 startingPage "468" @default.
- W4224230881 abstract "The nucleosome remodeling and deacetylase (NuRD) complex is one of the central chromatin remodeling complexes that mediates gene repression. NuRD is essential for numerous developmental events, including heart development. Clinical and genetic studies have provided direct evidence for the role of chromodomain helicase DNA-binding protein 4 (CHD4), the catalytic component of NuRD, in congenital heart disease (CHD), including atrial and ventricular septal defects. Furthermore, it has been demonstrated that CHD4 is essential for mammalian cardiomyocyte formation and function. A key unresolved question is how CHD4/NuRD is localized to specific cardiac target genes, as neither CHD4 nor NuRD can directly bind DNA. Here, we coupled a bioinformatics-based approach with mass spectrometry analyses to demonstrate that CHD4 interacts with the core cardiac transcription factors GATA4, NKX2-5, and TBX5 during embryonic heart development. Using transcriptomics and genome-wide occupancy data, we characterized the genomic landscape of GATA4, NKX2-5, and TBX5 repression and defined the direct cardiac gene targets of the GATA4–CHD4, NKX2-5–CHD4, and TBX5-CHD4 complexes. These data were used to identify putative cis -regulatory elements controlled by these complexes. We genetically interrogated two of these silencers in vivo: Acta1 and Myh11 . We show that deletion of these silencers leads to inappropriate skeletal and smooth muscle gene misexpression, respectively, in the embryonic heart. These results delineate how CHD4/NuRD is localized to specific cardiac loci and explicates how mutations in the broadly expressed CHD4 protein lead to cardiac-specific disease states." @default.
- W4224230881 created "2022-04-26" @default.
- W4224230881 creator A5001468756 @default.
- W4224230881 creator A5005006089 @default.
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- W4224230881 creator A5050568621 @default.
- W4224230881 creator A5076662333 @default.
- W4224230881 creator A5091470716 @default.
- W4224230881 date "2022-04-01" @default.
- W4224230881 modified "2023-10-17" @default.
- W4224230881 title "CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene programs in the developing heart" @default.
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