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• W4224233931 abstract "Exposure to heat stress during a cow's dry period disrupts mammary gland remodeling, impairing mammary function and milk production during the subsequent lactation. Yet, proteomic changes in the mammary gland underlying these effects are not yet known. We investigated alterations in the mammary proteome and phosphoproteome during lactation as a result of dry period heat stress using an isobaric tag for relative and absolute quantitation (iTRAQ)-based approach. Cows were cooled (CL; n = 12) with fans and water soakers in a free stall setting or were heat stressed through lack of access to cooling devices (HT; n = 12) during the entire dry period (approximately 46 days). All cows were cooled postpartum. Mammary biopsies were harvested from a subset of cows (n = 4 per treatment) at 14, 42, and 84 days in milk. Overall, 251 proteins and 224 phosphorylated proteins were differentially abundant in the lactating mammary gland of HT compared to CL cows. Top functions of differentially abundant proteins and phosphoproteins affected were related to immune function and inflammation, amino acid metabolism, reactive oxygen species production and metabolism, tissue remodeling, and cell stress response. Patterns of protein expression and phosphorylation are indicative of increased oxidative stress, mammary gland restructuring, and immune dysregulation due to prior exposure to dry period heat stress. This study provides insights into the molecular underpinnings of disrupted mammary function and health during lactation arising from prior exposure to dry period heat stress, which might have led to lower milk yields." @default.
• W4224233931 created "2022-04-26" @default.
• W4224233931 creator A5016912736 @default.
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• W4224233931 creator A5074294558 @default.
• W4224233931 date "2022-04-22" @default.
• W4224233931 modified "2023-10-02" @default.
• W4224233931 title "Carry-over effects of dry period heat stress on the mammary gland proteome and phosphoproteome in the subsequent lactation of dairy cows" @default.
• W4224233931 cites W133261840 @default.
• W4224233931 cites W1517477254 @default.
• W4224233931 cites W1549299892 @default.
• W4224233931 cites W1665175313 @default.
• W4224233931 cites W1874751834 @default.
• W4224233931 cites W1964895626 @default.
• W4224233931 cites W1969134338 @default.
• W4224233931 cites W1971028519 @default.
• W4224233931 cites W1975461927 @default.
• W4224233931 cites W1981813892 @default.
• W4224233931 cites W1990286763 @default.
• W4224233931 cites W1993457485 @default.
• W4224233931 cites W1993539840 @default.
• W4224233931 cites W2000263433 @default.
• W4224233931 cites W2010820226 @default.
• W4224233931 cites W2018352219 @default.
• W4224233931 cites W2018422534 @default.
• W4224233931 cites W2023746083 @default.
• W4224233931 cites W2028161249 @default.
• W4224233931 cites W2037771051 @default.
• W4224233931 cites W2040272587 @default.
• W4224233931 cites W2041228471 @default.
• W4224233931 cites W2044308879 @default.
• W4224233931 cites W2050332363 @default.
• W4224233931 cites W2052641547 @default.
• W4224233931 cites W2057616220 @default.
• W4224233931 cites W2057681397 @default.
• W4224233931 cites W2060997721 @default.
• W4224233931 cites W2063021349 @default.
• W4224233931 cites W2069369772 @default.
• W4224233931 cites W2075070902 @default.
• W4224233931 cites W2087262155 @default.
• W4224233931 cites W2095503516 @default.
• W4224233931 cites W2095887558 @default.
• W4224233931 cites W2105113130 @default.
• W4224233931 cites W2105769527 @default.
• W4224233931 cites W2107511188 @default.
• W4224233931 cites W2112078820 @default.
• W4224233931 cites W2114551066 @default.
• W4224233931 cites W2115129497 @default.
• W4224233931 cites W2118439154 @default.
• W4224233931 cites W2122519546 @default.
• W4224233931 cites W2124024633 @default.
• W4224233931 cites W2127022285 @default.
• W4224233931 cites W2133690125 @default.
• W4224233931 cites W2157918066 @default.
• W4224233931 cites W2167243619 @default.
• W4224233931 cites W2260031603 @default.
• W4224233931 cites W2273209570 @default.
• W4224233931 cites W2308927362 @default.
• W4224233931 cites W2398251883 @default.
• W4224233931 cites W2441430675 @default.
• W4224233931 cites W2583281873 @default.
• W4224233931 cites W2620815113 @default.
• W4224233931 cites W2625579426 @default.
• W4224233931 cites W2635415917 @default.
• W4224233931 cites W2748276461 @default.
• W4224233931 cites W2767834783 @default.
• W4224233931 cites W2768499679 @default.
• W4224233931 cites W2769866456 @default.
• W4224233931 cites W2778152891 @default.
• W4224233931 cites W2803591909 @default.
• W4224233931 cites W2807814263 @default.
• W4224233931 cites W2808305854 @default.
• W4224233931 cites W2883109619 @default.
• W4224233931 cites W2883854646 @default.
• W4224233931 cites W2893254196 @default.
• W4224233931 cites W2900569176 @default.
• W4224233931 cites W2910354248 @default.
• W4224233931 cites W2911196833 @default.
• W4224233931 cites W2911814027 @default.
• W4224233931 cites W2944345783 @default.
• W4224233931 cites W2954941033 @default.
• W4224233931 cites W2974408823 @default.
• W4224233931 cites W2995503969 @default.
• W4224233931 cites W3006029259 @default.
• W4224233931 cites W3009671545 @default.
• W4224233931 cites W3110191273 @default.
• W4224233931 cites W3217570101 @default.
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• W4224233931 doi "https://doi.org/10.1038/s41598-022-10461-z" @default.
• W4224233931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35459770" @default.
• W4224233931 hasPublicationYear "2022" @default.
• W4224233931 type Work @default.
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• W4224233931 hasAuthorship W4224233931A5016912736 @default.

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