FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224234607> ?p ?o ?g. }

• W4224234607 endingPage "742" @default.
• W4224234607 startingPage "732" @default.
• W4224234607 abstract "Failure to close the ductus arteriosus, patent ductus arteriosus, accounts for 10% of all congenital heart defects. Despite significant advances in patent ductus arteriosus management, including pharmacological treatment targeting the prostaglandin pathway, a proportion of patients fail to respond and must undergo surgical intervention. Thus, further refinement of the cellular and molecular mechanisms that govern vascular remodeling of this vessel is required.We performed single-cell RNA-sequencing of the ductus arteriosus in mouse embryos at E18.5 (embryonic day 18.5), and P0.5 (postnatal day 0.5), and P5 to identify transcriptional alterations that might be associated with remodeling. We further confirmed our findings using transgenic mouse models coupled with immunohistochemistry analysis.The intermediate filament vimentin emerged as a candidate that might contribute to closure of the ductus arteriosus. Indeed, mice with genetic deletion of vimentin fail to complete vascular remodeling of the ductus arteriosus. To seek mechanisms, we turned to the RNA-sequencing data that indicated changes in Jagged1 with similar profile to vimentin and pointed to potential links with Notch. In fact, Notch3 signaling was impaired in vimentin null mice and vimentin null mice phenocopies patent ductus arteriosus in Jagged1 endothelial and smooth muscle deleted mice.Through single-cell RNA-sequencing and by tracking closure of the ductus arteriosus in mice, we uncovered the unexpected contribution of vimentin in driving complete closure of the ductus arteriosus through a mechanism that includes deregulation of the Notch signaling pathway." @default.
• W4224234607 created "2022-04-26" @default.
• W4224234607 creator A5003153288 @default.
• W4224234607 creator A5004905921 @default.
• W4224234607 creator A5011670317 @default.
• W4224234607 creator A5020529360 @default.
• W4224234607 creator A5039961461 @default.
• W4224234607 creator A5079630919 @default.
• W4224234607 creator A5085035277 @default.
• W4224234607 creator A5085932274 @default.
• W4224234607 date "2022-06-01" @default.
• W4224234607 modified "2023-10-13" @default.
• W4224234607 title "Transcriptional Evaluation of the Ductus Arteriosus at the Single-Cell Level Uncovers a Requirement for Vim (Vimentin) for Complete Closure" @default.
• W4224234607 cites W1482444677 @default.
• W4224234607 cites W1878317805 @default.
• W4224234607 cites W1973096186 @default.
• W4224234607 cites W1988866780 @default.
• W4224234607 cites W1994250985 @default.
• W4224234607 cites W1999563934 @default.
• W4224234607 cites W2012349627 @default.
• W4224234607 cites W2024244834 @default.
• W4224234607 cites W2024603935 @default.
• W4224234607 cites W2028945983 @default.
• W4224234607 cites W2038232173 @default.
• W4224234607 cites W2045700058 @default.
• W4224234607 cites W2074138980 @default.
• W4224234607 cites W2076709150 @default.
• W4224234607 cites W2100974704 @default.
• W4224234607 cites W2114638148 @default.
• W4224234607 cites W2142353117 @default.
• W4224234607 cites W2144879614 @default.
• W4224234607 cites W2147648839 @default.
• W4224234607 cites W2149000174 @default.
• W4224234607 cites W2153045264 @default.
• W4224234607 cites W2161444917 @default.
• W4224234607 cites W2167160069 @default.
• W4224234607 cites W2223210804 @default.
• W4224234607 cites W2465823824 @default.
• W4224234607 cites W2483742247 @default.
• W4224234607 cites W2619876526 @default.
• W4224234607 cites W2809303335 @default.
• W4224234607 cites W2926273414 @default.
• W4224234607 cites W2970253393 @default.
• W4224234607 cites W2986040377 @default.
• W4224234607 cites W3136241758 @default.
• W4224234607 cites W3154072271 @default.
• W4224234607 cites W4220927067 @default.
• W4224234607 doi "https://doi.org/10.1161/atvbaha.121.317172" @default.
• W4224234607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35443793" @default.
• W4224234607 hasPublicationYear "2022" @default.
• W4224234607 type Work @default.
• W4224234607 citedByCount "8" @default.
• W4224234607 countsByYear W42242346072022 @default.
• W4224234607 countsByYear W42242346072023 @default.
• W4224234607 crossrefType "journal-article" @default.
• W4224234607 hasAuthorship W4224234607A5003153288 @default.
• W4224234607 hasAuthorship W4224234607A5004905921 @default.
• W4224234607 hasAuthorship W4224234607A5011670317 @default.
• W4224234607 hasAuthorship W4224234607A5020529360 @default.
• W4224234607 hasAuthorship W4224234607A5039961461 @default.
• W4224234607 hasAuthorship W4224234607A5079630919 @default.
• W4224234607 hasAuthorship W4224234607A5085035277 @default.
• W4224234607 hasAuthorship W4224234607A5085932274 @default.
• W4224234607 hasBestOaLocation W42242346071 @default.
• W4224234607 hasConcept C126322002 @default.
• W4224234607 hasConcept C142724271 @default.
• W4224234607 hasConcept C147447768 @default.
• W4224234607 hasConcept C203014093 @default.
• W4224234607 hasConcept C204232928 @default.
• W4224234607 hasConcept C2781236024 @default.
• W4224234607 hasConcept C71924100 @default.
• W4224234607 hasConcept C86803240 @default.
• W4224234607 hasConcept C95444343 @default.
• W4224234607 hasConceptScore W4224234607C126322002 @default.
• W4224234607 hasConceptScore W4224234607C142724271 @default.
• W4224234607 hasConceptScore W4224234607C147447768 @default.
• W4224234607 hasConceptScore W4224234607C203014093 @default.
• W4224234607 hasConceptScore W4224234607C204232928 @default.
• W4224234607 hasConceptScore W4224234607C2781236024 @default.
• W4224234607 hasConceptScore W4224234607C71924100 @default.
• W4224234607 hasConceptScore W4224234607C86803240 @default.
• W4224234607 hasConceptScore W4224234607C95444343 @default.
• W4224234607 hasIssue "6" @default.
• W4224234607 hasLocation W42242346071 @default.
• W4224234607 hasLocation W42242346072 @default.
• W4224234607 hasLocation W42242346073 @default.
• W4224234607 hasLocation W42242346074 @default.
• W4224234607 hasOpenAccess W4224234607 @default.
• W4224234607 hasPrimaryLocation W42242346071 @default.
• W4224234607 hasRelatedWork W1994328700 @default.
• W4224234607 hasRelatedWork W2013762445 @default.
• W4224234607 hasRelatedWork W2389543151 @default.
• W4224234607 hasRelatedWork W2414428146 @default.
• W4224234607 hasRelatedWork W2442705245 @default.
• W4224234607 hasRelatedWork W2530816000 @default.
• W4224234607 hasRelatedWork W3087597853 @default.
• W4224234607 hasRelatedWork W37660807 @default.
• W4224234607 hasRelatedWork W4253804708 @default.

• next