Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224238045> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4224238045 abstract "Abstract Background: Asthma is a heterogeneous disease with wide range of symptoms. Severe asthma exacerbations (SAEs) are characterized by worsening symptoms and bronchospasm requiring emergency department visits. In addition to conventional strategies for SAEs (inhaled β-agonists, anticholinergics, and systemic corticosteroids), another pharmacological option is represented by ketamine. Objective : To explore the role of ketamine in refractory SAEs. Methods : We performed a systematic search on PubMed and EMBASE up to August 12th, 2021. We selected prospective studies only, and outcomes of interest were: oxygenation/respiratory parameters, clinical status, need for invasive ventilation and effects on weaning. Results : We included a total of seven studies, five being randomized controlled trials (RCTs, population range 44-92 patients). The two small prospective studies (n=10 and n=11) did not have a control group. Four studies focused on adults, and three enrolled a pediatric population. We found large heterogeneity regarding sample size, age and gender distribution, inclusion criteria (different severity scores, if any) and ketamine dosing (bolus and/or continuous infusion). Of the five RCTs, three compared ketamine to placebo, while one used fentanyl and the other aminophylline. The outcomes evaluated by the included studies were highly variable. Despite paucity of data and large heterogeneity, an overview of the included studies suggests absence of clear benefit produced by ketamine in patients with refractory SAE, and some signals towards side effects. Conclusions : Our systematic review does not support the use of ketamine in refractory SAE. A limited number of prospective studies with large heterogeneity was found. Well-designed multicenter RCT are desirable." @default.
- W4224238045 created "2022-04-26" @default.
- W4224238045 creator A5007659198 @default.
- W4224238045 creator A5014594048 @default.
- W4224238045 creator A5016462787 @default.
- W4224238045 creator A5024666907 @default.
- W4224238045 creator A5024772834 @default.
- W4224238045 creator A5041328216 @default.
- W4224238045 creator A5051209607 @default.
- W4224238045 creator A5067785009 @default.
- W4224238045 date "2022-04-20" @default.
- W4224238045 modified "2023-09-27" @default.
- W4224238045 title "Use of ketamine in patients with refractory severe asthma exacerbations: systematic review of prospective studies." @default.
- W4224238045 doi "https://doi.org/10.21203/rs.3.rs-1550818/v1" @default.
- W4224238045 hasPublicationYear "2022" @default.
- W4224238045 type Work @default.
- W4224238045 citedByCount "0" @default.
- W4224238045 crossrefType "posted-content" @default.
- W4224238045 hasAuthorship W4224238045A5007659198 @default.
- W4224238045 hasAuthorship W4224238045A5014594048 @default.
- W4224238045 hasAuthorship W4224238045A5016462787 @default.
- W4224238045 hasAuthorship W4224238045A5024666907 @default.
- W4224238045 hasAuthorship W4224238045A5024772834 @default.
- W4224238045 hasAuthorship W4224238045A5041328216 @default.
- W4224238045 hasAuthorship W4224238045A5051209607 @default.
- W4224238045 hasAuthorship W4224238045A5067785009 @default.
- W4224238045 hasBestOaLocation W42242380451 @default.
- W4224238045 hasConcept C118552586 @default.
- W4224238045 hasConcept C126322002 @default.
- W4224238045 hasConcept C142724271 @default.
- W4224238045 hasConcept C168563851 @default.
- W4224238045 hasConcept C177713679 @default.
- W4224238045 hasConcept C188816634 @default.
- W4224238045 hasConcept C204787440 @default.
- W4224238045 hasConcept C27081682 @default.
- W4224238045 hasConcept C2776042228 @default.
- W4224238045 hasConcept C2777288759 @default.
- W4224238045 hasConcept C2780724011 @default.
- W4224238045 hasConcept C2780795376 @default.
- W4224238045 hasConcept C2908647359 @default.
- W4224238045 hasConcept C42219234 @default.
- W4224238045 hasConcept C535046627 @default.
- W4224238045 hasConcept C71924100 @default.
- W4224238045 hasConcept C99454951 @default.
- W4224238045 hasConceptScore W4224238045C118552586 @default.
- W4224238045 hasConceptScore W4224238045C126322002 @default.
- W4224238045 hasConceptScore W4224238045C142724271 @default.
- W4224238045 hasConceptScore W4224238045C168563851 @default.
- W4224238045 hasConceptScore W4224238045C177713679 @default.
- W4224238045 hasConceptScore W4224238045C188816634 @default.
- W4224238045 hasConceptScore W4224238045C204787440 @default.
- W4224238045 hasConceptScore W4224238045C27081682 @default.
- W4224238045 hasConceptScore W4224238045C2776042228 @default.
- W4224238045 hasConceptScore W4224238045C2777288759 @default.
- W4224238045 hasConceptScore W4224238045C2780724011 @default.
- W4224238045 hasConceptScore W4224238045C2780795376 @default.
- W4224238045 hasConceptScore W4224238045C2908647359 @default.
- W4224238045 hasConceptScore W4224238045C42219234 @default.
- W4224238045 hasConceptScore W4224238045C535046627 @default.
- W4224238045 hasConceptScore W4224238045C71924100 @default.
- W4224238045 hasConceptScore W4224238045C99454951 @default.
- W4224238045 hasLocation W42242380451 @default.
- W4224238045 hasOpenAccess W4224238045 @default.
- W4224238045 hasPrimaryLocation W42242380451 @default.
- W4224238045 hasRelatedWork W1530958247 @default.
- W4224238045 hasRelatedWork W2069550437 @default.
- W4224238045 hasRelatedWork W2158273200 @default.
- W4224238045 hasRelatedWork W2467351604 @default.
- W4224238045 hasRelatedWork W2797018696 @default.
- W4224238045 hasRelatedWork W2977797331 @default.
- W4224238045 hasRelatedWork W2980093723 @default.
- W4224238045 hasRelatedWork W3015718133 @default.
- W4224238045 hasRelatedWork W3154944956 @default.
- W4224238045 hasRelatedWork W4322724676 @default.
- W4224238045 isParatext "false" @default.
- W4224238045 isRetracted "false" @default.
- W4224238045 workType "article" @default.