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• W4224238982 abstract "Early chimerism analysis is important to assess engraftment in allogeneic hematopoietic stem cell transplantations.We retrospectively investigated the impact of T-cell chimerism at day 30 in bone marrow on acute graft-versus-host disease (aGVHD), relapse, and overall survival in 142 adult allo-transplanted patients.The majority of patients (89%) received myeloablative conditioning and 90% have undergone T-cell replete donor graft. At day 30, 103 patients showed T-complete chimerism with prevalence in haploidentical transplants, whereas 39 cases had CD3+ mixed chimerism, including 30 patients transplanted with HLA identical donors, and 21 with T-cell donors<90%. T-cell chimerism at day 30 was weakly inversely related to aGVHD grades II-IV (p = .078) with no cases of grades III-IV aGVHD in patients with CD3+ <95%. Mixed T-cell chimerism did not impact on relapse (p = .448) and five of the seven patients who relapsed had T-cell chimerism ≤90%. Older age and active disease at transplant had a statistically significant negative effect on overall survival (p = .01 and p = .0001, respectively), whereas mixed CD3+ chimerism did not.T lymphocyte chimerism analysis at day +30 in bone marrow could identify allo-transplanted patients at major risk of aGVHD grades III-IV (CD3+ donors >95%) mainly post-myeloablative conditioning regimen." @default.
• W4224238982 created "2022-04-26" @default.
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• W4224238982 date "2022-04-27" @default.
• W4224238982 modified "2023-10-17" @default.
• W4224238982 title "Mixed T cell CHIMERISM in bone marrow at day+30 after allogeneic stem cell transplantation: Correlation with acute GVHD grades III–IV and no impact on relapse and overall survival" @default.
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• W4224238982 doi "https://doi.org/10.1111/ejh.13772" @default.
• W4224238982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35389543" @default.
• W4224238982 hasPublicationYear "2022" @default.
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