FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224242871> ?p ?o ?g. }

• W4224242871 endingPage "77" @default.
• W4224242871 startingPage "67" @default.
• W4224242871 abstract "CCND1 is located on 11q13. Increased CCND1 copy number (CN) in breast cancer (BC) is associated with high histopathological grade, high proliferation, and Luminal B subtype. In this study of CCND1 in primary BCs and corresponding axillary lymph node metastases (LNM),we examine associations between CCND1 CN in primary BCs and proliferation status, molecular subtype, and prognosis. Furthermore, we studied associations between CCND1 CN and CNs of FGFR1 and ZNF703, both of which are located on 8p12. Fluorescence in situ hybridization probes for CCND1 and chromosome 11 centromere were used on tissue microarrays comprising 526 BCs and 123 LNM. We assessed associations between CCND1 CN and tumour characteristics using Pearson's χ2 test, and estimated cumulative risks of death from BC and hazard ratios in analysis of prognosis. We found CCND1 CN ≥ 4 < 6 in 45 (8.6%) tumours, and ≥ 6 in 42 (8.0%). CCND1 CN (≥ 6) was seen in all molecular subtypes, most frequently in Luminal B (HER2-) (20/126; 16%). Increased CCND1 CN was associated with high histopathological grade, high Ki-67, and high mitotic count, but not prognosis. CCND1 CN ≥ 6 was accompanied by CN increase of FGFR1 in 6/40 cases (15.0%) and ZNF703 in 5/38 cases (13.2%). Three cases showed CN increase of all three genes. High CCND1 CN was most frequent in Luminal B (HER2-) tumours. Good correlation between CCND1 CNs in BCs and LNM was observed. Despite associations between high CCND1 CN and aggressive tumour characteristics, the prognostic impact of CCND1 CN remains unresolved." @default.
• W4224242871 created "2022-04-26" @default.
• W4224242871 creator A5013748536 @default.
• W4224242871 creator A5036638690 @default.
• W4224242871 creator A5055622780 @default.
• W4224242871 creator A5088098082 @default.
• W4224242871 date "2022-03-01" @default.
• W4224242871 modified "2023-10-05" @default.
• W4224242871 title "CCND1 Amplification in Breast Cancer -associations With Proliferation, Histopathological Grade, Molecular Subtype and Prognosis" @default.
• W4224242871 cites W1918275087 @default.
• W4224242871 cites W1974507771 @default.
• W4224242871 cites W1978606283 @default.
• W4224242871 cites W1985160458 @default.
• W4224242871 cites W1998646002 @default.
• W4224242871 cites W2002339899 @default.
• W4224242871 cites W2005156019 @default.
• W4224242871 cites W2005895632 @default.
• W4224242871 cites W2019494460 @default.
• W4224242871 cites W2037438735 @default.
• W4224242871 cites W2044551606 @default.
• W4224242871 cites W2048082729 @default.
• W4224242871 cites W2048721919 @default.
• W4224242871 cites W2058602228 @default.
• W4224242871 cites W2058879820 @default.
• W4224242871 cites W2072303535 @default.
• W4224242871 cites W2081562657 @default.
• W4224242871 cites W2088138591 @default.
• W4224242871 cites W2098546316 @default.
• W4224242871 cites W2101844536 @default.
• W4224242871 cites W2109424608 @default.
• W4224242871 cites W2118155696 @default.
• W4224242871 cites W2119040192 @default.
• W4224242871 cites W2121664015 @default.
• W4224242871 cites W2131679528 @default.
• W4224242871 cites W2136780580 @default.
• W4224242871 cites W2138798180 @default.
• W4224242871 cites W2142095017 @default.
• W4224242871 cites W2142271087 @default.
• W4224242871 cites W2145846672 @default.
• W4224242871 cites W2170309255 @default.
• W4224242871 cites W2303366562 @default.
• W4224242871 cites W2527091694 @default.
• W4224242871 cites W2769695566 @default.
• W4224242871 cites W2783999439 @default.
• W4224242871 cites W2806209829 @default.
• W4224242871 cites W2892516835 @default.
• W4224242871 cites W2898640786 @default.
• W4224242871 cites W2915766093 @default.
• W4224242871 cites W2924412259 @default.
• W4224242871 cites W2944883972 @default.
• W4224242871 cites W2966387629 @default.
• W4224242871 cites W3000512538 @default.
• W4224242871 cites W3015634062 @default.
• W4224242871 cites W3033547765 @default.
• W4224242871 cites W3119029482 @default.
• W4224242871 cites W3127785161 @default.
• W4224242871 cites W3129726793 @default.
• W4224242871 cites W3138196060 @default.
• W4224242871 cites W3158013991 @default.
• W4224242871 cites W3163964295 @default.
• W4224242871 doi "https://doi.org/10.1007/s10911-022-09516-8" @default.
• W4224242871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35459982" @default.
• W4224242871 hasPublicationYear "2022" @default.
• W4224242871 type Work @default.
• W4224242871 citedByCount "12" @default.
• W4224242871 countsByYear W42242428712022 @default.
• W4224242871 countsByYear W42242428712023 @default.
• W4224242871 crossrefType "journal-article" @default.
• W4224242871 hasAuthorship W4224242871A5013748536 @default.
• W4224242871 hasAuthorship W4224242871A5036638690 @default.
• W4224242871 hasAuthorship W4224242871A5055622780 @default.
• W4224242871 hasAuthorship W4224242871A5088098082 @default.
• W4224242871 hasBestOaLocation W42242428711 @default.
• W4224242871 hasConcept C104317684 @default.
• W4224242871 hasConcept C121608353 @default.
• W4224242871 hasConcept C126322002 @default.
• W4224242871 hasConcept C142724271 @default.
• W4224242871 hasConcept C199835354 @default.
• W4224242871 hasConcept C2777542201 @default.
• W4224242871 hasConcept C29537977 @default.
• W4224242871 hasConcept C30481170 @default.
• W4224242871 hasConcept C502942594 @default.
• W4224242871 hasConcept C530470458 @default.
• W4224242871 hasConcept C54355233 @default.
• W4224242871 hasConcept C71924100 @default.
• W4224242871 hasConcept C86803240 @default.
• W4224242871 hasConceptScore W4224242871C104317684 @default.
• W4224242871 hasConceptScore W4224242871C121608353 @default.
• W4224242871 hasConceptScore W4224242871C126322002 @default.
• W4224242871 hasConceptScore W4224242871C142724271 @default.
• W4224242871 hasConceptScore W4224242871C199835354 @default.
• W4224242871 hasConceptScore W4224242871C2777542201 @default.
• W4224242871 hasConceptScore W4224242871C29537977 @default.
• W4224242871 hasConceptScore W4224242871C30481170 @default.
• W4224242871 hasConceptScore W4224242871C502942594 @default.
• W4224242871 hasConceptScore W4224242871C530470458 @default.
• W4224242871 hasConceptScore W4224242871C54355233 @default.
• W4224242871 hasConceptScore W4224242871C71924100 @default.

• next