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• W4224243422 endingPage "1955.e7" @default.
• W4224243422 startingPage "1940" @default.
• W4224243422 abstract "Previously, we showed that CDYL1 is recruited to DNA double-strand breaks (DSBs) to promote homologous recombination (HR) repair and foster transcriptional silencing. However, how CDYL1 elicits DSB-induced silencing is not fully understood. Here, we identify a CDYL1-dependent local decrease in the transcriptionally active marks histone lysine crotonylation (Kcr) and crotonylated lysine 9 of H3 (H3K9cr) at AsiSI-induced DSBs, which correlates with transcriptional silencing. Mechanistically, we reveal that CDYL1 crotonyl-CoA hydratase activity counteracts Kcr and H3K9cr at DSB sites, which triggers the eviction of the transcription elongation factor ENL and fosters transcriptional silencing. Furthermore, genetic inhibition of CDYL1 hydratase activity blocks the reduction in H3K9cr and alleviates DSB-induced silencing, whereas HR efficiency unexpectedly remains intact. Therefore, our results functionally uncouple the repair and silencing activity of CDYL1 at DSBs. In a broader context, we address a long-standing question concerning the functional relationship between HR repair and DSB-induced silencing, suggesting that they may occur independently." @default.
• W4224243422 created "2022-04-26" @default.
• W4224243422 creator A5010887655 @default.
• W4224243422 creator A5013772716 @default.
• W4224243422 creator A5055595160 @default.
• W4224243422 creator A5071374079 @default.
• W4224243422 creator A5084069582 @default.
• W4224243422 creator A5087380110 @default.
• W4224243422 date "2022-05-01" @default.
• W4224243422 modified "2023-09-30" @default.
• W4224243422 title "CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair" @default.
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• W4224243422 doi "https://doi.org/10.1016/j.molcel.2022.03.031" @default.
• W4224243422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35447080" @default.
• W4224243422 hasPublicationYear "2022" @default.
• W4224243422 type Work @default.
• W4224243422 citedByCount "9" @default.

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