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• W4224243468 endingPage "100344" @default.
• W4224243468 startingPage "100344" @default.
• W4224243468 abstract "The kidneys are responsible for maintaining physiologic homeostasis. The kidneys clear a variety of drugs and other substances through passive (filtration) and active processes that utilize transport proteins. Renal clearance is comprised of the processes of glomerular filtration, tubular secretion, and tubular reabsorption. Endogenous biomarkers, such as creatinine and cystatin C, are routinely used to estimate renal clearance. Understanding the contributing components of renal function and clearance, through the use of biomarkers, is necessary in elucidating the renal pharmacology of drugs and other substances. While exogenous markers of kidney function have been known for decades, several complexities have limited their usage. Several endogenous markers are being evaluated and hold promise to elucidate the individual components of kidney function that represent filtration, secretion, and reabsorption." @default.
• W4224243468 created "2022-04-26" @default.
• W4224243468 creator A5014587329 @default.
• W4224243468 creator A5045125159 @default.
• W4224243468 date "2022-09-01" @default.
• W4224243468 modified "2023-09-27" @default.
• W4224243468 title "Endogenous markers of kidney function and renal drug clearance processes of filtration, secretion, and reabsorption" @default.
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• W4224243468 doi "https://doi.org/10.1016/j.cotox.2022.03.005" @default.

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