FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224246346> ?p ?o ?g. }

• W4224246346 endingPage "36" @default.
• W4224246346 startingPage "26" @default.
• W4224246346 abstract "Acanthamoeba keratitis (AK) is a severe cause of infectious keratitis and represents a significant clinical challenge. Recent literature regarding AK epidemiology, diagnosis, treatment modalities, and prognosis is reviewed and synthesized to propose an algorithmic protocol for AK management. Globally, AK outbreaks in developed countries are ongoing, and AK rates have increased. Moreover, current outbreaks may carry a worse prognosis than prior outbreaks. Despite identification of contact lens solutions implicated in AK outbreaks and the consequent market recall of these products, outbreaks persist. Acanthamoeba keratitis afflicts not only refractive soft contact lens users but also cosmetic contact lens users and gas permeable (especially orthokeratology) lens users. Innovations in in vivo confocal microscopy and PCR assays have increased the role for these adjuvant tests alongside corneal smear and culture in a multimodal diagnostic approach to suspected AK. Biguanides (such as chlorhexidine and polyhexamethylene biguanide) and diamidines (propamidine isethionate and hexamidine) remain cornerstones of AK management, and evidence for other treatment modalities continues to evolve. Voriconazole in topical and systemic forms may be useful as adjuvant therapy. The anti-leishmaniasis drug miltefosine, recently given orphan drug status by the United States Food and Drug Administration, has increasing evidence supporting a role in patients with severe/refractory disease. Prior topical corticosteroids have been consistently shown to be associated with worse outcomes in AK. Although not historically thought of as a treatment modality, benzalkonium chloride preservative may be leveraged for its anti-Acanthamoebal properties. The role of Rose-Bengal photodynamic antimicrobial therapy is evolving in selected cases of AK." @default.
• W4224246346 created "2022-04-26" @default.
• W4224246346 creator A5034648190 @default.
• W4224246346 creator A5082098748 @default.
• W4224246346 date "2022-07-01" @default.
• W4224246346 modified "2023-10-16" @default.
• W4224246346 title "Advances in the management of Acanthamoeba keratitis: A review of the literature and synthesized algorithmic approach" @default.
• W4224246346 cites W136192803 @default.
• W4224246346 cites W1797850445 @default.
• W4224246346 cites W1905272171 @default.
• W4224246346 cites W1965909799 @default.
• W4224246346 cites W1966796774 @default.
• W4224246346 cites W1969098344 @default.
• W4224246346 cites W1969832384 @default.
• W4224246346 cites W1970541239 @default.
• W4224246346 cites W1972207424 @default.
• W4224246346 cites W1972794777 @default.
• W4224246346 cites W1974408086 @default.
• W4224246346 cites W1976049730 @default.
• W4224246346 cites W1976635568 @default.
• W4224246346 cites W1977766844 @default.
• W4224246346 cites W1977805248 @default.
• W4224246346 cites W1978640630 @default.
• W4224246346 cites W1979642103 @default.
• W4224246346 cites W1981213996 @default.
• W4224246346 cites W1981775985 @default.
• W4224246346 cites W1983561712 @default.
• W4224246346 cites W1984409867 @default.
• W4224246346 cites W1984563949 @default.
• W4224246346 cites W1985959768 @default.
• W4224246346 cites W1987536428 @default.
• W4224246346 cites W1987951206 @default.
• W4224246346 cites W1989259760 @default.
• W4224246346 cites W1989469399 @default.
• W4224246346 cites W1999260768 @default.
• W4224246346 cites W2006454502 @default.
• W4224246346 cites W2027944987 @default.
• W4224246346 cites W2030788839 @default.
• W4224246346 cites W2032944990 @default.
• W4224246346 cites W2035451782 @default.
• W4224246346 cites W2036050997 @default.
• W4224246346 cites W2045871300 @default.
• W4224246346 cites W2052534954 @default.
• W4224246346 cites W2055594094 @default.
• W4224246346 cites W2057151209 @default.
• W4224246346 cites W2058314813 @default.
• W4224246346 cites W2061465974 @default.
• W4224246346 cites W2066134711 @default.
• W4224246346 cites W2066317750 @default.
• W4224246346 cites W2066514494 @default.
• W4224246346 cites W2068610969 @default.
• W4224246346 cites W2071954849 @default.
• W4224246346 cites W2072190185 @default.
• W4224246346 cites W2072868355 @default.
• W4224246346 cites W2076151302 @default.
• W4224246346 cites W2080400654 @default.
• W4224246346 cites W2092146721 @default.
• W4224246346 cites W2092942446 @default.
• W4224246346 cites W2096296061 @default.
• W4224246346 cites W2098956961 @default.
• W4224246346 cites W2113798987 @default.
• W4224246346 cites W2118738972 @default.
• W4224246346 cites W2122729357 @default.
• W4224246346 cites W2130348869 @default.
• W4224246346 cites W2133589872 @default.
• W4224246346 cites W2139279262 @default.
• W4224246346 cites W2149732945 @default.
• W4224246346 cites W2152337305 @default.
• W4224246346 cites W2160403363 @default.
• W4224246346 cites W2160420092 @default.
• W4224246346 cites W2160944345 @default.
• W4224246346 cites W2164455183 @default.
• W4224246346 cites W2168618596 @default.
• W4224246346 cites W2172294091 @default.
• W4224246346 cites W2215794557 @default.
• W4224246346 cites W2292716546 @default.
• W4224246346 cites W2299699902 @default.
• W4224246346 cites W2303287452 @default.
• W4224246346 cites W2320544160 @default.
• W4224246346 cites W2321041447 @default.
• W4224246346 cites W2321997958 @default.
• W4224246346 cites W2322304294 @default.
• W4224246346 cites W2329621078 @default.
• W4224246346 cites W2332213631 @default.
• W4224246346 cites W2334900052 @default.
• W4224246346 cites W2335810422 @default.
• W4224246346 cites W2340310443 @default.
• W4224246346 cites W2345556806 @default.
• W4224246346 cites W2511501835 @default.
• W4224246346 cites W2516727702 @default.
• W4224246346 cites W2555691009 @default.
• W4224246346 cites W2575354981 @default.
• W4224246346 cites W2579423980 @default.
• W4224246346 cites W2618530636 @default.
• W4224246346 cites W2740515247 @default.
• W4224246346 cites W2758265418 @default.
• W4224246346 cites W2765329086 @default.
• W4224246346 cites W2770488718 @default.

• next