FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224248323> ?p ?o ?g. }

• W4224248323 endingPage "12" @default.
• W4224248323 startingPage "11" @default.
• W4224248323 abstract "Sjogren syndrome is an autoimmune disease characterised by lymphocytic infiltration and inflammation of the exocrine glands resulting in decreased secretion of involved glands which manifests mostly as dry eye and dry mouth. The prevalence of the disease is reported to be about 10.3 per 10,000 population. It is more common in females with a male: female ratio of 16:1. Extra glandular manifestations are seen in up to 1/3rd of the cases. Renal involvement is seen in 4.9% of patients with Sjogren syndrome.Here we present three cases of Sjogren Syndrome who presented to our hospital with hypokalaemic quadriparesis.On evaluation all three of the patients were found to have renal tubular acidosis type 1. None of these patients had any symptom of Sjogren syndrome before the onset of quadriparesis. All of these patients had acute onset progressive areflexic quadriparesis with involvement of facial muscles and drooping of eyelids without sensory or bladder bowel involvement. One of these patients had respiratory muscle paralysis severe enough to mandate mechanical ventilation. Arterial Blood Gas analysis and urine electrolyte analysis were suggestive of type 1 renal tubular acidosis. ANA positive in 2 of the 3 patients. Anti-SSA & anti-SSB antibodies were positive in all three patients. Supportive measures and IV fluid and electrolyte correction was done. There was complete recovery of power in all three patients and were discharged on oral medications.Renal Tubular Acidosis is characterised by inability of the nephrons to maintain physiologic acid base balance. This usually results from a defect in the tubular transport mechanisms. Distal Renal tubular acidosis (as in these patients) is further defined by an alkalotic urinary pH(>5.5) and profound hypokalemia due to impairment in H+ secretion in ditstal tubular alpha-intercalated cells. Owing to this imbalance of ionic transport in distal tubules there can be nephrocalcinosis, nephrolithiasis, rickets and severe muscle weakness. Sjogren syndrome is one of the etiologies leading to development of T1RTA.T1RTA can be the presenting feature of Sjogren Syndrome.Though a rare manifestation of the disease if can be the presenting symptom. Work up for RTA (ABG, urine electrolytes, Urine PH and osmolarity etc) in patients with hypokalaemic paresis can help establish the etiological diagnosis(ANA, anti-SSA,anti-SSB) and help prevent future relapses of the disease." @default.
• W4224248323 created "2022-04-26" @default.
• W4224248323 creator A5046547492 @default.
• W4224248323 creator A5057361515 @default.
• W4224248323 creator A5058993492 @default.
• W4224248323 creator A5076226395 @default.
• W4224248323 date "2022-04-01" @default.
• W4224248323 modified "2023-09-29" @default.
• W4224248323 title "Type 1 Renal Tubular Acidosis with Hypokalemic Quadriparesis in Sjogren Syndrome." @default.
• W4224248323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35443430" @default.
• W4224248323 hasPublicationYear "2022" @default.
• W4224248323 type Work @default.
• W4224248323 citedByCount "0" @default.
• W4224248323 crossrefType "journal-article" @default.
• W4224248323 hasAuthorship W4224248323A5046547492 @default.
• W4224248323 hasAuthorship W4224248323A5057361515 @default.
• W4224248323 hasAuthorship W4224248323A5058993492 @default.
• W4224248323 hasAuthorship W4224248323A5076226395 @default.
• W4224248323 hasConcept C126322002 @default.
• W4224248323 hasConcept C2776598079 @default.
• W4224248323 hasConcept C2776940978 @default.
• W4224248323 hasConcept C2777373371 @default.
• W4224248323 hasConcept C2778129702 @default.
• W4224248323 hasConcept C2778553927 @default.
• W4224248323 hasConcept C2779246250 @default.
• W4224248323 hasConcept C2779573558 @default.
• W4224248323 hasConcept C2781079508 @default.
• W4224248323 hasConcept C2908647359 @default.
• W4224248323 hasConcept C71924100 @default.
• W4224248323 hasConcept C90924648 @default.
• W4224248323 hasConcept C99454951 @default.
• W4224248323 hasConceptScore W4224248323C126322002 @default.
• W4224248323 hasConceptScore W4224248323C2776598079 @default.
• W4224248323 hasConceptScore W4224248323C2776940978 @default.
• W4224248323 hasConceptScore W4224248323C2777373371 @default.
• W4224248323 hasConceptScore W4224248323C2778129702 @default.
• W4224248323 hasConceptScore W4224248323C2778553927 @default.
• W4224248323 hasConceptScore W4224248323C2779246250 @default.
• W4224248323 hasConceptScore W4224248323C2779573558 @default.
• W4224248323 hasConceptScore W4224248323C2781079508 @default.
• W4224248323 hasConceptScore W4224248323C2908647359 @default.
• W4224248323 hasConceptScore W4224248323C71924100 @default.
• W4224248323 hasConceptScore W4224248323C90924648 @default.
• W4224248323 hasConceptScore W4224248323C99454951 @default.
• W4224248323 hasIssue "4" @default.
• W4224248323 hasLocation W42242483231 @default.
• W4224248323 hasOpenAccess W4224248323 @default.
• W4224248323 hasPrimaryLocation W42242483231 @default.
• W4224248323 hasRelatedWork W11161464 @default.
• W4224248323 hasRelatedWork W15935862 @default.
• W4224248323 hasRelatedWork W16201762 @default.
• W4224248323 hasRelatedWork W3924505 @default.
• W4224248323 hasRelatedWork W493768 @default.
• W4224248323 hasRelatedWork W6563503 @default.
• W4224248323 hasRelatedWork W7132394 @default.
• W4224248323 hasRelatedWork W7211866 @default.
• W4224248323 hasRelatedWork W841837 @default.
• W4224248323 hasRelatedWork W16843603 @default.
• W4224248323 hasVolume "70" @default.
• W4224248323 isParatext "false" @default.
• W4224248323 isRetracted "false" @default.
• W4224248323 workType "article" @default.