Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224251024> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4224251024 abstract "Antibody CIS43 binds Plasmodium falciparum circumsporozoite protein (PfCSP) and protects against malaria, as recently demonstrated clinically. To improve the efficacy of CIS43, we developed an in silico pipeline to optimize the interaction energy of CIS43 to its junctional epitope (peptide 21: PfCSP residues 101-115). Starting from two improved CIS43 variants, recently elicited from a CIS43-germline knock-in mice, single and double amino acid substitutions in the peptide 21-proximal heavy (VH) and light (VL) variable regions were introduced. CIS43-variants, selected on the basis of improved in silico interface and stability energies, showed increased affinity to peptide 21 and superior malaria-protective efficacy. The best designed variant, antibody P3-43, was significantly more protective than its template antibody m43.151, with greater liver-burden protection than the current best-in-class (antibody iGL-CIS43.D3). Crystal structures of improved antibodies revealed atomic-level interactions explaining gains in binding affinity. The reported pipeline provides a powerful in silico approach to improve antibody functionality." @default.
- W4224251024 created "2022-04-26" @default.
- W4224251024 creator A5012251819 @default.
- W4224251024 creator A5013430827 @default.
- W4224251024 creator A5014565765 @default.
- W4224251024 creator A5014752118 @default.
- W4224251024 creator A5035571273 @default.
- W4224251024 creator A5043677118 @default.
- W4224251024 creator A5043695651 @default.
- W4224251024 creator A5053250604 @default.
- W4224251024 creator A5054265317 @default.
- W4224251024 creator A5056415356 @default.
- W4224251024 creator A5061200264 @default.
- W4224251024 creator A5062072610 @default.
- W4224251024 creator A5064773426 @default.
- W4224251024 creator A5069492259 @default.
- W4224251024 creator A5073226093 @default.
- W4224251024 creator A5075647746 @default.
- W4224251024 creator A5077572229 @default.
- W4224251024 creator A5089740833 @default.
- W4224251024 date "2022-04-09" @default.
- W4224251024 modified "2023-10-16" @default.
- W4224251024 title "In Silico Improvement of Highly Protective Anti-Malarial Antibodies" @default.
- W4224251024 doi "https://doi.org/10.1101/2022.04.08.487687" @default.
- W4224251024 hasPublicationYear "2022" @default.
- W4224251024 type Work @default.
- W4224251024 citedByCount "0" @default.
- W4224251024 crossrefType "posted-content" @default.
- W4224251024 hasAuthorship W4224251024A5012251819 @default.
- W4224251024 hasAuthorship W4224251024A5013430827 @default.
- W4224251024 hasAuthorship W4224251024A5014565765 @default.
- W4224251024 hasAuthorship W4224251024A5014752118 @default.
- W4224251024 hasAuthorship W4224251024A5035571273 @default.
- W4224251024 hasAuthorship W4224251024A5043677118 @default.
- W4224251024 hasAuthorship W4224251024A5043695651 @default.
- W4224251024 hasAuthorship W4224251024A5053250604 @default.
- W4224251024 hasAuthorship W4224251024A5054265317 @default.
- W4224251024 hasAuthorship W4224251024A5056415356 @default.
- W4224251024 hasAuthorship W4224251024A5061200264 @default.
- W4224251024 hasAuthorship W4224251024A5062072610 @default.
- W4224251024 hasAuthorship W4224251024A5064773426 @default.
- W4224251024 hasAuthorship W4224251024A5069492259 @default.
- W4224251024 hasAuthorship W4224251024A5073226093 @default.
- W4224251024 hasAuthorship W4224251024A5075647746 @default.
- W4224251024 hasAuthorship W4224251024A5077572229 @default.
- W4224251024 hasAuthorship W4224251024A5089740833 @default.
- W4224251024 hasBestOaLocation W42242510241 @default.
- W4224251024 hasConcept C104317684 @default.
- W4224251024 hasConcept C159047783 @default.
- W4224251024 hasConcept C159654299 @default.
- W4224251024 hasConcept C185592680 @default.
- W4224251024 hasConcept C195616568 @default.
- W4224251024 hasConcept C203014093 @default.
- W4224251024 hasConcept C2775905019 @default.
- W4224251024 hasConcept C2778048844 @default.
- W4224251024 hasConcept C2778371730 @default.
- W4224251024 hasConcept C2779281246 @default.
- W4224251024 hasConcept C2781074509 @default.
- W4224251024 hasConcept C2781377902 @default.
- W4224251024 hasConcept C55493867 @default.
- W4224251024 hasConcept C70721500 @default.
- W4224251024 hasConcept C86803240 @default.
- W4224251024 hasConceptScore W4224251024C104317684 @default.
- W4224251024 hasConceptScore W4224251024C159047783 @default.
- W4224251024 hasConceptScore W4224251024C159654299 @default.
- W4224251024 hasConceptScore W4224251024C185592680 @default.
- W4224251024 hasConceptScore W4224251024C195616568 @default.
- W4224251024 hasConceptScore W4224251024C203014093 @default.
- W4224251024 hasConceptScore W4224251024C2775905019 @default.
- W4224251024 hasConceptScore W4224251024C2778048844 @default.
- W4224251024 hasConceptScore W4224251024C2778371730 @default.
- W4224251024 hasConceptScore W4224251024C2779281246 @default.
- W4224251024 hasConceptScore W4224251024C2781074509 @default.
- W4224251024 hasConceptScore W4224251024C2781377902 @default.
- W4224251024 hasConceptScore W4224251024C55493867 @default.
- W4224251024 hasConceptScore W4224251024C70721500 @default.
- W4224251024 hasConceptScore W4224251024C86803240 @default.
- W4224251024 hasLocation W42242510241 @default.
- W4224251024 hasOpenAccess W4224251024 @default.
- W4224251024 hasPrimaryLocation W42242510241 @default.
- W4224251024 hasRelatedWork W13793023 @default.
- W4224251024 hasRelatedWork W16073534 @default.
- W4224251024 hasRelatedWork W17625577 @default.
- W4224251024 hasRelatedWork W2734805 @default.
- W4224251024 hasRelatedWork W4681189 @default.
- W4224251024 hasRelatedWork W5621644 @default.
- W4224251024 hasRelatedWork W7329232 @default.
- W4224251024 hasRelatedWork W8247226 @default.
- W4224251024 hasRelatedWork W8558331 @default.
- W4224251024 hasRelatedWork W16806827 @default.
- W4224251024 isParatext "false" @default.
- W4224251024 isRetracted "false" @default.
- W4224251024 workType "article" @default.