FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224251368> ?p ?o ?g. }

• W4224251368 endingPage "121528" @default.
• W4224251368 startingPage "121528" @default.
• W4224251368 abstract "Immunotherapy maintains the cancer-immunity cycle via re-activating the immune system, so as to achieve the purpose of anti-tumor. However, the response rate of current tumor immunotherapy strategies is still low. Even the most reported immune checkpoint block (ICB), the objective response rate (ORR) is only about 10-30%. Here, aiming at obtaining a higher response rate, we designed a cascade amplification nanocomposite consisting of the immune adjuvant polyinosinic:polycytidylic acid [Poly (I:C)] and aggregation-induced emission luminogen (AIEgen)-modified modular peptide (named PMRA). The PMRA includes: DPPA-1 peptide (P), an immune checkpoint inhibitor; PLGLAG peptide (M), a matrix metalloproteinase 2 (MMP-2) responsive sequence to promote the release of DPPA-1; RRRRRRRR peptide (R), for loading the Poly (I:C); PyTPA (A), a photosensitizer with AIE property. In cancer-immunity cycle, photodynamic therapy (PDT) mediated by PyTPA promotes the release of tumor-associated antigens (TAAs), and primes T lymphocytes. The cytokines coming from the stimulation of PDT and Poly (I:C) promote the activation of T lymphocytes. The high level of chemokines in tumor microenvironment promotes immune cells migration and infiltration in tumor with the assistance of PDT. Finally, through ICB with DPPA-1 peptide, T lymphocytes enhance the recognition of tumor cells and killing tumor cells. Immunogenic cell death induces the release of more TAAs, which will enter the next cycle and complete the full-loop again. Taking advantages of whole cancer-immunity cycle, the cascade amplification nanocomposite achieved almost 100% ORR in vivo. This concept of whole cancer-immunity cycle enhanced immunotherapy provides a novel perspective for tumor treatment." @default.
• W4224251368 created "2022-04-26" @default.
• W4224251368 creator A5002518897 @default.
• W4224251368 creator A5032433456 @default.
• W4224251368 creator A5047572956 @default.
• W4224251368 creator A5063131315 @default.
• W4224251368 creator A5070660616 @default.
• W4224251368 creator A5076755421 @default.
• W4224251368 creator A5078265090 @default.
• W4224251368 creator A5088198922 @default.
• W4224251368 creator A5088632274 @default.
• W4224251368 date "2022-06-01" @default.
• W4224251368 modified "2023-10-14" @default.
• W4224251368 title "A peptide-AIEgen nanocomposite mediated whole cancer immunity cycle-cascade amplification for improved immunotherapy of tumor" @default.
• W4224251368 cites W1524125877 @default.
• W4224251368 cites W1981439401 @default.
• W4224251368 cites W1982488143 @default.
• W4224251368 cites W2060070314 @default.
• W4224251368 cites W2068064088 @default.
• W4224251368 cites W2151734986 @default.
• W4224251368 cites W2165838507 @default.
• W4224251368 cites W2292383635 @default.
• W4224251368 cites W2578528809 @default.
• W4224251368 cites W2744892122 @default.
• W4224251368 cites W2772811279 @default.
• W4224251368 cites W2773003990 @default.
• W4224251368 cites W2793364080 @default.
• W4224251368 cites W2800477374 @default.
• W4224251368 cites W2888586602 @default.
• W4224251368 cites W2896691409 @default.
• W4224251368 cites W2898871166 @default.
• W4224251368 cites W2902185751 @default.
• W4224251368 cites W2903067379 @default.
• W4224251368 cites W2908838385 @default.
• W4224251368 cites W2914311347 @default.
• W4224251368 cites W2914518223 @default.
• W4224251368 cites W2938697269 @default.
• W4224251368 cites W2947828752 @default.
• W4224251368 cites W2948559837 @default.
• W4224251368 cites W2953750576 @default.
• W4224251368 cites W2968223269 @default.
• W4224251368 cites W2968804289 @default.
• W4224251368 cites W2976182269 @default.
• W4224251368 cites W2977511465 @default.
• W4224251368 cites W2981487371 @default.
• W4224251368 cites W2982245165 @default.
• W4224251368 cites W2996284693 @default.
• W4224251368 cites W2997391673 @default.
• W4224251368 cites W3001533030 @default.
• W4224251368 cites W3003310139 @default.
• W4224251368 cites W3004737123 @default.
• W4224251368 cites W3004769637 @default.
• W4224251368 cites W3005671296 @default.
• W4224251368 cites W3009432377 @default.
• W4224251368 cites W3010033244 @default.
• W4224251368 cites W3013600101 @default.
• W4224251368 cites W3016231863 @default.
• W4224251368 cites W3025247294 @default.
• W4224251368 cites W3026606749 @default.
• W4224251368 cites W3027032991 @default.
• W4224251368 cites W3036296795 @default.
• W4224251368 cites W3038105921 @default.
• W4224251368 cites W3045863463 @default.
• W4224251368 cites W3082210897 @default.
• W4224251368 cites W3082333872 @default.
• W4224251368 cites W3087341228 @default.
• W4224251368 cites W3089059583 @default.
• W4224251368 cites W3090386083 @default.
• W4224251368 cites W3091863067 @default.
• W4224251368 cites W3102549282 @default.
• W4224251368 cites W3104731987 @default.
• W4224251368 cites W3111158352 @default.
• W4224251368 cites W3114344131 @default.
• W4224251368 cites W3118839146 @default.
• W4224251368 cites W3128646645 @default.
• W4224251368 cites W3135870777 @default.
• W4224251368 cites W3158899292 @default.
• W4224251368 cites W3175275490 @default.
• W4224251368 cites W3176194173 @default.
• W4224251368 cites W3181345198 @default.
• W4224251368 cites W3185683642 @default.
• W4224251368 cites W3194627459 @default.
• W4224251368 cites W3200223875 @default.
• W4224251368 cites W3214745736 @default.
• W4224251368 cites W4313383212 @default.
• W4224251368 doi "https://doi.org/10.1016/j.biomaterials.2022.121528" @default.
• W4224251368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35487065" @default.
• W4224251368 hasPublicationYear "2022" @default.
• W4224251368 type Work @default.
• W4224251368 citedByCount "15" @default.
• W4224251368 countsByYear W42242513682022 @default.
• W4224251368 countsByYear W42242513682023 @default.
• W4224251368 crossrefType "journal-article" @default.
• W4224251368 hasAuthorship W4224251368A5002518897 @default.
• W4224251368 hasAuthorship W4224251368A5032433456 @default.
• W4224251368 hasAuthorship W4224251368A5047572956 @default.
• W4224251368 hasAuthorship W4224251368A5063131315 @default.
• W4224251368 hasAuthorship W4224251368A5070660616 @default.

• next