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• W4224251603 endingPage "368" @default.
• W4224251603 startingPage "368" @default.
• W4224251603 abstract "Ferroptosis is a recently discovered form of cell death which differs from other forms of cell death in terms of morphology, biochemistry, and regulatory mechanisms. Ferroptosis is regulated by a complex system and the precise molecular mechanisms are still being elucidated. Over the past few years, extensive research has revealed that the essence of ferroptosis is iron-dependent accumulation of lipid hydroperoxides induced by oxidative stress, and the System Xc-glutathione (GSH)-glutathione peroxidase 4 (GPX4) pathway is the main ferroptosis prevention system. Meanwhile, other antioxidant systems have also been implicated in regulating ferroptosis, including the transsulfuration pathway, mevalonate pathway, ferroptosis inhibitory protein 1 (FSP1)-Coenzyme Q10 (CoQ10) pathway, dihydroorotate dehydrogenase (DHODH)-dihydroubiquione (CoQH2) pathway, and GTP cyclohydrolase-1 (GCH1)-tetrahydrobiopterin (BH4) pathway. This article reviews the molecular mechanisms of ferroptosis and its critical role in antioxidant systems, aiming to reveal that antioxidation is an important method of inhibiting ferroptosis and to provide a new direction for the treatment of ferroptosis-related diseases.We searched all original papers and reviews about the molecular mechanisms of ferroptosis in antioxidant systems using PubMed to November 2021. The search terms used included: 'ferroptosis', 'ferroptosis inducers', 'ferroptosis inhibitors', 'ferroptosis and GSH', 'ferroptosis and GPX4', 'ferroptosis and System Xc-', 'SLC7A11', 'P53', 'NRF2 and ferroptosis', 'iron metabolism', 'lipid peroxidation', 'antioxidant systems', 'transsulfuration pathway', 'mevalonate pathway', 'FSP1-CoQ10', 'DHODH-CoQH2', and 'GCH1-BH4'.We first introduced the origin of ferroptosis and its common inhibitors and inducers. Next, we discussed the molecular mechanisms of ferroptosis and its role in antioxidant systems in existing studies. Finally, we briefly summarized the relationship between ferroptosis and diseases. It reveals that antioxidation is an important method of inhibiting ferroptosis.This review discusses the recent rapid progress in the understanding of the molecular mechanisms of ferroptosis and its role in several antioxidant systems." @default.
• W4224251603 created "2022-04-26" @default.
• W4224251603 creator A5002044446 @default.
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• W4224251603 creator A5089180350 @default.
• W4224251603 creator A5089524638 @default.
• W4224251603 date "2022-03-01" @default.
• W4224251603 modified "2023-10-06" @default.
• W4224251603 title "The critical role and molecular mechanisms of ferroptosis in antioxidant systems: a narrative review" @default.
• W4224251603 cites W1525431558 @default.
• W4224251603 cites W1567389274 @default.
• W4224251603 cites W1589007430 @default.
• W4224251603 cites W1798710600 @default.
• W4224251603 cites W1990618897 @default.
• W4224251603 cites W1997183854 @default.
• W4224251603 cites W2007794772 @default.
• W4224251603 cites W2016063936 @default.
• W4224251603 cites W2034005931 @default.
• W4224251603 cites W2047114123 @default.
• W4224251603 cites W2050746675 @default.
• W4224251603 cites W2053387982 @default.
• W4224251603 cites W2068972343 @default.
• W4224251603 cites W2072814384 @default.
• W4224251603 cites W2076822925 @default.
• W4224251603 cites W2078905435 @default.
• W4224251603 cites W2080292234 @default.
• W4224251603 cites W2087389434 @default.
• W4224251603 cites W2094347708 @default.
• W4224251603 cites W2103590517 @default.
• W4224251603 cites W2153839710 @default.
• W4224251603 cites W2163005196 @default.
• W4224251603 cites W2214441024 @default.
• W4224251603 cites W2265062179 @default.
• W4224251603 cites W2300320800 @default.
• W4224251603 cites W2327321006 @default.
• W4224251603 cites W2327686392 @default.
• W4224251603 cites W2414659015 @default.
• W4224251603 cites W2417659148 @default.
• W4224251603 cites W2439394256 @default.
• W4224251603 cites W2508296626 @default.
• W4224251603 cites W2549428458 @default.
• W4224251603 cites W2550324626 @default.
• W4224251603 cites W2582111083 @default.
• W4224251603 cites W2583594489 @default.
• W4224251603 cites W2617266043 @default.
• W4224251603 cites W2619512829 @default.
• W4224251603 cites W2745520112 @default.
• W4224251603 cites W2745891591 @default.
• W4224251603 cites W2751075893 @default.
• W4224251603 cites W2762087180 @default.
• W4224251603 cites W2769025225 @default.
• W4224251603 cites W2778262854 @default.
• W4224251603 cites W2783702177 @default.
• W4224251603 cites W2788640168 @default.
• W4224251603 cites W2794021749 @default.
• W4224251603 cites W2797485983 @default.
• W4224251603 cites W2804789540 @default.
• W4224251603 cites W2876414845 @default.
• W4224251603 cites W2883979293 @default.
• W4224251603 cites W2892710900 @default.
• W4224251603 cites W2900171085 @default.
• W4224251603 cites W2901592874 @default.
• W4224251603 cites W2909817598 @default.
• W4224251603 cites W2911996561 @default.
• W4224251603 cites W2914036211 @default.
• W4224251603 cites W2932226998 @default.
• W4224251603 cites W2946704044 @default.
• W4224251603 cites W2954162996 @default.
• W4224251603 cites W2979398595 @default.
• W4224251603 cites W2979641493 @default.
• W4224251603 cites W2979799294 @default.
• W4224251603 cites W2979937337 @default.
• W4224251603 cites W2980343169 @default.
• W4224251603 cites W2980472864 @default.
• W4224251603 cites W2982991142 @default.
• W4224251603 cites W2985539554 @default.
• W4224251603 cites W2988499404 @default.
• W4224251603 cites W2988889252 @default.
• W4224251603 cites W2997323331 @default.
• W4224251603 cites W3003960907 @default.
• W4224251603 cites W3005253578 @default.
• W4224251603 cites W3008659291 @default.
• W4224251603 cites W3009652528 @default.
• W4224251603 cites W3010943409 @default.
• W4224251603 cites W3012295934 @default.
• W4224251603 cites W3012782412 @default.
• W4224251603 cites W3014098551 @default.
• W4224251603 cites W3015312656 @default.
• W4224251603 cites W3016288444 @default.
• W4224251603 cites W3020890805 @default.
• W4224251603 cites W3034353096 @default.
• W4224251603 cites W3038057715 @default.
• W4224251603 cites W3039789423 @default.

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