Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224252643> ?p ?o ?g. }
- W4224252643 endingPage "328" @default.
- W4224252643 startingPage "321" @default.
- W4224252643 abstract "Gut microbiota and its metabolite bile acids may play a significant role in the occurrence and development of major depressive disorder (MDD). Therefore, this study analyzes gut microbiota and bile acids, as well as their correlation in patients.Thirty-one patients with MDD and 29 healthy controls (HCs) were enrolled in this study. We collected their both blood and feces. Plasma bile acid content was determined by liquid chromatography-mass spectrometry and gut microbiota was detected by 16SrRNA gene sequencing and subsequently analyzed. We also analyzed the correlation between different gut microbiota, bile acids, and Hamilton Depression (HAMD) score.The α-diversity analysis found that Simpson and Pielou evenness index was much higher in HCs than in the patients with MDD. The β-diversity of the two groups were differences by nonmetric multidimensional scaling analysis. Linear discriminant analysis effect size analysis identified 16 different strains. Bile acids detection showed that 23-nordeoxycholic acid in patients with MDD was significantly higher than in HCs, whereas taurolithocholic acid (TLCA), glycolithocholic acid (GLCA), and lithocholic acid 3-sulfate were significantly lower. Spearman correlation analysis showed that Turicibacteraceae, Turicibacterales, and Turicibacter were positively related with TLCA, GLCA, glycodeoxycholic acid (GDCA), and taurodeoxycholic acid, and were negatively correlated with HAMD score. At the same time, TLCA, GLCA, and GDCA were negatively correlated with HAMD score.Gut microbiota and bile acids metabolism are disturbances in MDD, and there exists a correlation between gut microbiota and bile acids metabolism. Moreover, their interaction may be related to the pathophysiological mechanism of MDD." @default.
- W4224252643 created "2022-04-26" @default.
- W4224252643 creator A5010330641 @default.
- W4224252643 creator A5028797869 @default.
- W4224252643 creator A5046359891 @default.
- W4224252643 creator A5050971786 @default.
- W4224252643 creator A5055388661 @default.
- W4224252643 creator A5071200615 @default.
- W4224252643 creator A5072128957 @default.
- W4224252643 creator A5073501391 @default.
- W4224252643 creator A5082116380 @default.
- W4224252643 date "2022-05-23" @default.
- W4224252643 modified "2023-10-10" @default.
- W4224252643 title "Abnormal gut microbiota and bile acids in patients with first‐episode major depressive disorder and correlation analysis" @default.
- W4224252643 cites W1768927256 @default.
- W4224252643 cites W1837857344 @default.
- W4224252643 cites W1977804070 @default.
- W4224252643 cites W2022454496 @default.
- W4224252643 cites W2033386838 @default.
- W4224252643 cites W2051718333 @default.
- W4224252643 cites W2091052564 @default.
- W4224252643 cites W2093009918 @default.
- W4224252643 cites W2103038927 @default.
- W4224252643 cites W2130896556 @default.
- W4224252643 cites W2132629114 @default.
- W4224252643 cites W2134354994 @default.
- W4224252643 cites W2134897177 @default.
- W4224252643 cites W2162904770 @default.
- W4224252643 cites W2163702170 @default.
- W4224252643 cites W2280231561 @default.
- W4224252643 cites W2292048640 @default.
- W4224252643 cites W2335888891 @default.
- W4224252643 cites W2337492846 @default.
- W4224252643 cites W2345616653 @default.
- W4224252643 cites W2428595929 @default.
- W4224252643 cites W2571547641 @default.
- W4224252643 cites W2611167501 @default.
- W4224252643 cites W2624747407 @default.
- W4224252643 cites W2794227656 @default.
- W4224252643 cites W2799891707 @default.
- W4224252643 cites W2895770947 @default.
- W4224252643 cites W2902315967 @default.
- W4224252643 cites W2944975624 @default.
- W4224252643 cites W3001047124 @default.
- W4224252643 cites W3004112707 @default.
- W4224252643 cites W3005084624 @default.
- W4224252643 cites W3007172709 @default.
- W4224252643 cites W3012981415 @default.
- W4224252643 cites W3032916792 @default.
- W4224252643 cites W3049499252 @default.
- W4224252643 cites W3058117360 @default.
- W4224252643 cites W3083883133 @default.
- W4224252643 cites W3098019302 @default.
- W4224252643 cites W3110621449 @default.
- W4224252643 cites W3119745320 @default.
- W4224252643 cites W3128539702 @default.
- W4224252643 cites W3164581399 @default.
- W4224252643 cites W3184541229 @default.
- W4224252643 cites W3186566903 @default.
- W4224252643 cites W3196309794 @default.
- W4224252643 cites W3197082108 @default.
- W4224252643 cites W4225554953 @default.
- W4224252643 cites W3110200838 @default.
- W4224252643 doi "https://doi.org/10.1111/pcn.13368" @default.
- W4224252643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35445772" @default.
- W4224252643 hasPublicationYear "2022" @default.
- W4224252643 type Work @default.
- W4224252643 citedByCount "12" @default.
- W4224252643 countsByYear W42242526432022 @default.
- W4224252643 countsByYear W42242526432023 @default.
- W4224252643 crossrefType "journal-article" @default.
- W4224252643 hasAuthorship W4224252643A5010330641 @default.
- W4224252643 hasAuthorship W4224252643A5028797869 @default.
- W4224252643 hasAuthorship W4224252643A5046359891 @default.
- W4224252643 hasAuthorship W4224252643A5050971786 @default.
- W4224252643 hasAuthorship W4224252643A5055388661 @default.
- W4224252643 hasAuthorship W4224252643A5071200615 @default.
- W4224252643 hasAuthorship W4224252643A5072128957 @default.
- W4224252643 hasAuthorship W4224252643A5073501391 @default.
- W4224252643 hasAuthorship W4224252643A5082116380 @default.
- W4224252643 hasConcept C117220453 @default.
- W4224252643 hasConcept C126322002 @default.
- W4224252643 hasConcept C2524010 @default.
- W4224252643 hasConcept C2777198177 @default.
- W4224252643 hasConcept C2779144063 @default.
- W4224252643 hasConcept C2779399885 @default.
- W4224252643 hasConcept C2780051608 @default.
- W4224252643 hasConcept C2780420665 @default.
- W4224252643 hasConcept C3018023364 @default.
- W4224252643 hasConcept C33923547 @default.
- W4224252643 hasConcept C42407357 @default.
- W4224252643 hasConcept C539455810 @default.
- W4224252643 hasConcept C55493867 @default.
- W4224252643 hasConcept C61716771 @default.
- W4224252643 hasConcept C71924100 @default.
- W4224252643 hasConcept C86803240 @default.
- W4224252643 hasConcept C89423630 @default.
- W4224252643 hasConceptScore W4224252643C117220453 @default.