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- W4224252832 abstract "Implantable bioelectrodes enable precise recording or stimulation of electrical signals with living tissues in close contact. However, their performance is frequently compromised owing to inflammatory tissue reactions, which macrophages either induce or resolve by polarizing to an inflammatory (M1) or noninflammatory (M2) phenotype, respectively. Thus, we aimed to fabricate biocompatible and functional implantable conductive polymer bioelectrodes with optimal topography for the modulation of macrophage responses. To this end, we produced heparin-doped polypyrrole (PPy/Hep) electrodes of different surface roughness, with Ra values from 5.5 to 17.6 nm, by varying the charge densities during electrochemical synthesis. In vitro culture revealed that macrophages on rough PPy/Hep electrodes preferentially polarized to noninflammatory phenotypes. In particular, PPy/Hep-900 (Ra = 14 nm) was optimal with respect to electrochemical properties and the suppression of inflammatory M1 polarization. In vivo implantation indicated that PPy/Hep-900 significantly reduced macrophage recruitment, suppressed inflammatory polarization, and mitigated fibrotic tissue formation. In addition, the implanted PPy/Hep-900 electrodes could successfully record electrocardiographic signals for up to 10 days without substantial decreases in sensitivity, while other electrodes substantially lost their signal sensitivity during implantation. Altogether, we demonstrate that modulating the surface features of PPy/Hep can benefit the design and applications of high-performance and high-biocompatibility bioelectrodes." @default.
- W4224252832 created "2022-04-26" @default.
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- W4224252832 date "2022-04-19" @default.
- W4224252832 modified "2023-10-15" @default.
- W4224252832 title "High-Performance Implantable Bioelectrodes with Immunocompatible Topography for Modulation of Macrophage Responses" @default.
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- W4224252832 doi "https://doi.org/10.1021/acsnano.1c10506" @default.
- W4224252832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35438981" @default.
- W4224252832 hasPublicationYear "2022" @default.
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