FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224253246> ?p ?o ?g. }

• W4224253246 endingPage "1680" @default.
• W4224253246 startingPage "1680" @default.
• W4224253246 abstract "Gamma-aminobutyric acid (GABA) is a natural amino acid with antioxidant activity and is often considered to have therapeutic potential against obesity. Obesity has long been linked to ROS and ER stress, but the effect of GABA on the ROS-associated ER stress axis has not been thoroughly explored. Thus, in this study, the effect of GABA and fermented Curcuma longa L. extract enriched with GABA (FCLL-GABA) on the ROS-related ER stress axis and inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α) sulfonation were examined with the HFD model to determine the underlying anti-obesity mechanism. Here, GABA and FCLL-GABA supplementations significantly inhibited the weight gain in HFD fed mice. The GABA and FCLL-GABA supplementation lowered the expressions of adipogenic transcription factors such as PPAR-γ, C/EBPα, FAS, and SREBP-1c in white adipose tissue (WAT) and liver from HFD-fed mice. The enhanced hyper-nutrient dysmetabolism-based NADPH oxidase (Nox) 4 and the resultant IRE1α sulfonation-RIDD-SIRT1 decay under HFD conditions were controlled with GABA and FCLL-GABA. Notably, GABA and FCLL-GABA administration significantly increased AMPK and sirtuin 1 (SIRT1) levels in WAT of HFD-fed mice. These significant observations indicate that ER-localized Nox4-induced IRE1α sulfonation results in the decay of SIRT1 as a novel mechanism behind the positive implications of GABA on obesity. Moreover, the investigation lays a firm foundation for the development of FCLL-GABA as a functional ingredient." @default.
• W4224253246 created "2022-04-26" @default.
• W4224253246 creator A5020667712 @default.
• W4224253246 creator A5027293736 @default.
• W4224253246 creator A5030762704 @default.
• W4224253246 creator A5034143213 @default.
• W4224253246 creator A5040057122 @default.
• W4224253246 creator A5042013474 @default.
• W4224253246 creator A5061664783 @default.
• W4224253246 creator A5061963809 @default.
• W4224253246 creator A5066534237 @default.
• W4224253246 creator A5075693201 @default.
• W4224253246 date "2022-04-18" @default.
• W4224253246 modified "2023-10-18" @default.
• W4224253246 title "GABA and Fermented Curcuma longa L. Extract Enriched with GABA Ameliorate Obesity through Nox4-IRE1α Sulfonation-RIDD-SIRT1 Decay Axis in High-Fat Diet-Induced Obese Mice" @default.
• W4224253246 cites W1810681069 @default.
• W4224253246 cites W1977603207 @default.
• W4224253246 cites W1998040839 @default.
• W4224253246 cites W2000084288 @default.
• W4224253246 cites W2000223380 @default.
• W4224253246 cites W2007636933 @default.
• W4224253246 cites W2017713177 @default.
• W4224253246 cites W2019750418 @default.
• W4224253246 cites W2047001261 @default.
• W4224253246 cites W2047306805 @default.
• W4224253246 cites W2050397606 @default.
• W4224253246 cites W2058328046 @default.
• W4224253246 cites W2059467226 @default.
• W4224253246 cites W2061165871 @default.
• W4224253246 cites W2062360005 @default.
• W4224253246 cites W2064362934 @default.
• W4224253246 cites W2077033935 @default.
• W4224253246 cites W2077510975 @default.
• W4224253246 cites W2082502030 @default.
• W4224253246 cites W2091330563 @default.
• W4224253246 cites W2109086173 @default.
• W4224253246 cites W2119314929 @default.
• W4224253246 cites W2124821727 @default.
• W4224253246 cites W2128403738 @default.
• W4224253246 cites W2133077402 @default.
• W4224253246 cites W2137206981 @default.
• W4224253246 cites W2144600435 @default.
• W4224253246 cites W2144827966 @default.
• W4224253246 cites W2163208005 @default.
• W4224253246 cites W2167907853 @default.
• W4224253246 cites W2170591186 @default.
• W4224253246 cites W2180470224 @default.
• W4224253246 cites W2235679942 @default.
• W4224253246 cites W2292633092 @default.
• W4224253246 cites W2415267894 @default.
• W4224253246 cites W2462514513 @default.
• W4224253246 cites W2471605942 @default.
• W4224253246 cites W2508503153 @default.
• W4224253246 cites W2555778096 @default.
• W4224253246 cites W2722324655 @default.
• W4224253246 cites W2770515924 @default.
• W4224253246 cites W2786652970 @default.
• W4224253246 cites W2803807982 @default.
• W4224253246 cites W2903192705 @default.
• W4224253246 cites W2948112434 @default.
• W4224253246 cites W3100182689 @default.
• W4224253246 cites W3120097944 @default.
• W4224253246 cites W3159260246 @default.
• W4224253246 cites W3198420796 @default.
• W4224253246 cites W3209909429 @default.
• W4224253246 cites W4213105232 @default.
• W4224253246 doi "https://doi.org/10.3390/nu14081680" @default.
• W4224253246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35458241" @default.
• W4224253246 hasPublicationYear "2022" @default.
• W4224253246 type Work @default.
• W4224253246 citedByCount "5" @default.
• W4224253246 countsByYear W42242532462022 @default.
• W4224253246 countsByYear W42242532462023 @default.
• W4224253246 crossrefType "journal-article" @default.
• W4224253246 hasAuthorship W4224253246A5020667712 @default.
• W4224253246 hasAuthorship W4224253246A5027293736 @default.
• W4224253246 hasAuthorship W4224253246A5030762704 @default.
• W4224253246 hasAuthorship W4224253246A5034143213 @default.
• W4224253246 hasAuthorship W4224253246A5040057122 @default.
• W4224253246 hasAuthorship W4224253246A5042013474 @default.
• W4224253246 hasAuthorship W4224253246A5061664783 @default.
• W4224253246 hasAuthorship W4224253246A5061963809 @default.
• W4224253246 hasAuthorship W4224253246A5066534237 @default.
• W4224253246 hasAuthorship W4224253246A5075693201 @default.
• W4224253246 hasBestOaLocation W42242532461 @default.
• W4224253246 hasConcept C126322002 @default.
• W4224253246 hasConcept C134018914 @default.
• W4224253246 hasConcept C139447449 @default.
• W4224253246 hasConcept C158617107 @default.
• W4224253246 hasConcept C170493617 @default.
• W4224253246 hasConcept C184235292 @default.
• W4224253246 hasConcept C185592680 @default.
• W4224253246 hasConcept C2776151105 @default.
• W4224253246 hasConcept C2777771985 @default.
• W4224253246 hasConcept C2779177108 @default.
• W4224253246 hasConcept C2779719074 @default.
• W4224253246 hasConcept C2779765511 @default.
• W4224253246 hasConcept C2780124434 @default.

• next