Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224253455> ?p ?o ?g. }
- W4224253455 abstract "CD8 T cells mediate protection against intracellular pathogens and tumors. However, persistent antigen during chronic infections or cancer leads to T cell exhaustion, suboptimal functionality, and reduced protective capacity. Despite considerable work interrogating the transcriptional regulation of exhausted CD8 T cells (TEX), the posttranscriptional control of TEX remains poorly understood. Here, we interrogated the role of microRNAs (miRs) in CD8 T cells responding to acutely resolved or chronic viral infection and identified miR-29a as a key regulator of TEX. Enforced expression of miR-29a improved CD8 T cell responses during chronic viral infection and antagonized exhaustion. miR-29a inhibited exhaustion-driving transcriptional pathways, including inflammatory and T cell receptor signaling, and regulated ribosomal biogenesis. As a result, miR-29a fostered a memory-like CD8 T cell differentiation state during chronic infection. Thus, we identify miR-29a as a key regulator of TEX and define mechanisms by which miR-29a can divert exhaustion toward a more beneficial memory-like CD8 T cell differentiation state." @default.
- W4224253455 created "2022-04-26" @default.
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- W4224253455 date "2022-04-21" @default.
- W4224253455 modified "2023-10-02" @default.
- W4224253455 title "MicroRNA-29a attenuates CD8 T cell exhaustion and induces memory-like CD8 T cells during chronic infection" @default.
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- W4224253455 doi "https://doi.org/10.1073/pnas.2106083119" @default.
- W4224253455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35446623" @default.
- W4224253455 hasPublicationYear "2022" @default.
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