Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224253524> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W4224253524 endingPage "496" @default.
- W4224253524 startingPage "496" @default.
- W4224253524 abstract "Chondroitin sulfate (CS) E is the natural ligand for pleiotrophin (PTN) in the central nervous system (CNS) of the embryo. Some structures of PTN in solution have been solved, but no precise location of the binding site has been reported yet. Using 15N-labelled PTN and HSQC NMR experiments, we studied the interactions with a synthetic CS-E tetrasaccharide corresponding to the minimum binding sequence. The results agree with the data for larger GAG (glycosaminoglycans) sequences and confirm our hypothesis that a synthetic tetrasaccharide is long enough to fully interact with PTN. We hypothesize that the central region of PTN is an intrinsically disordered region (IDR) and could modify its properties upon binding. The second tetrasaccharide has two benzyl groups and shows similar effects on PTN. Finally, the last measured compound aggregated but beforehand, showed a behavior compatible with a slow exchange in the NMR time scale. We propose the same binding site and mode for the tetrasaccharides with and without benzyl groups." @default.
- W4224253524 created "2022-04-26" @default.
- W4224253524 creator A5003322039 @default.
- W4224253524 creator A5037235000 @default.
- W4224253524 creator A5049765140 @default.
- W4224253524 creator A5062250027 @default.
- W4224253524 date "2022-04-19" @default.
- W4224253524 modified "2023-10-18" @default.
- W4224253524 title "Pleiotrophin Interaction with Synthetic Glycosaminoglycan Mimetics" @default.
- W4224253524 cites W1550767186 @default.
- W4224253524 cites W1971372975 @default.
- W4224253524 cites W1977920448 @default.
- W4224253524 cites W2068227670 @default.
- W4224253524 cites W2076969774 @default.
- W4224253524 cites W2088320968 @default.
- W4224253524 cites W2092701914 @default.
- W4224253524 cites W2130931695 @default.
- W4224253524 cites W2132180320 @default.
- W4224253524 cites W2164833764 @default.
- W4224253524 cites W2278539535 @default.
- W4224253524 cites W2285620773 @default.
- W4224253524 cites W2298514306 @default.
- W4224253524 cites W2313422370 @default.
- W4224253524 cites W2469724685 @default.
- W4224253524 cites W3011324370 @default.
- W4224253524 cites W3126707852 @default.
- W4224253524 cites W3176908050 @default.
- W4224253524 cites W4220682895 @default.
- W4224253524 doi "https://doi.org/10.3390/ph15050496" @default.
- W4224253524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35631323" @default.
- W4224253524 hasPublicationYear "2022" @default.
- W4224253524 type Work @default.
- W4224253524 citedByCount "0" @default.
- W4224253524 crossrefType "journal-article" @default.
- W4224253524 hasAuthorship W4224253524A5003322039 @default.
- W4224253524 hasAuthorship W4224253524A5037235000 @default.
- W4224253524 hasAuthorship W4224253524A5049765140 @default.
- W4224253524 hasAuthorship W4224253524A5062250027 @default.
- W4224253524 hasBestOaLocation W42242535241 @default.
- W4224253524 hasConcept C100817775 @default.
- W4224253524 hasConcept C107824862 @default.
- W4224253524 hasConcept C116569031 @default.
- W4224253524 hasConcept C153074725 @default.
- W4224253524 hasConcept C170493617 @default.
- W4224253524 hasConcept C185592680 @default.
- W4224253524 hasConcept C2775960820 @default.
- W4224253524 hasConcept C2778041096 @default.
- W4224253524 hasConcept C2778297098 @default.
- W4224253524 hasConcept C2779553658 @default.
- W4224253524 hasConcept C2779822564 @default.
- W4224253524 hasConcept C55493867 @default.
- W4224253524 hasConcept C71240020 @default.
- W4224253524 hasConceptScore W4224253524C100817775 @default.
- W4224253524 hasConceptScore W4224253524C107824862 @default.
- W4224253524 hasConceptScore W4224253524C116569031 @default.
- W4224253524 hasConceptScore W4224253524C153074725 @default.
- W4224253524 hasConceptScore W4224253524C170493617 @default.
- W4224253524 hasConceptScore W4224253524C185592680 @default.
- W4224253524 hasConceptScore W4224253524C2775960820 @default.
- W4224253524 hasConceptScore W4224253524C2778041096 @default.
- W4224253524 hasConceptScore W4224253524C2778297098 @default.
- W4224253524 hasConceptScore W4224253524C2779553658 @default.
- W4224253524 hasConceptScore W4224253524C2779822564 @default.
- W4224253524 hasConceptScore W4224253524C55493867 @default.
- W4224253524 hasConceptScore W4224253524C71240020 @default.
- W4224253524 hasIssue "5" @default.
- W4224253524 hasLocation W42242535241 @default.
- W4224253524 hasLocation W42242535242 @default.
- W4224253524 hasLocation W42242535243 @default.
- W4224253524 hasOpenAccess W4224253524 @default.
- W4224253524 hasPrimaryLocation W42242535241 @default.
- W4224253524 hasRelatedWork W2021600913 @default.
- W4224253524 hasRelatedWork W2024768386 @default.
- W4224253524 hasRelatedWork W2063429768 @default.
- W4224253524 hasRelatedWork W2073557749 @default.
- W4224253524 hasRelatedWork W2121271975 @default.
- W4224253524 hasRelatedWork W2156297944 @default.
- W4224253524 hasRelatedWork W2414975270 @default.
- W4224253524 hasRelatedWork W2497831928 @default.
- W4224253524 hasRelatedWork W4220682895 @default.
- W4224253524 hasRelatedWork W4224253524 @default.
- W4224253524 hasVolume "15" @default.
- W4224253524 isParatext "false" @default.
- W4224253524 isRetracted "false" @default.
- W4224253524 workType "article" @default.