FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224254907> ?p ?o ?g. }

• W4224254907 endingPage "576" @default.
• W4224254907 startingPage "567" @default.
• W4224254907 abstract "Treatment-resistant depression (TRD) affects approximately 30% of patients with major depressive disorder (MDD), especially elderly patients. As individuals with TRD are at an increased risk of committing suicide and pose a higher risk of relapse, early diagnostic biomarkers of TRD and a better understanding of the resistance mechanism are highly needed. This study aimed to determine whether serum cortisol, nesfatin-1, and pro-inflammatory cytokines can be used as biomarkers for the diagnosis of elderly patients with TRD.Thirty elderly patients with TRD were selected as the TRD group. Thirty elderly patients with MDD who were effectively treated with conventional antidepressants were selected as the non-TRD group. The baseline levels of serum cortisol, nesfatin-1, and pro-inflammatory cytokines were measured and compared, and their diagnostic values were evaluated using the receiver operating characteristic (ROC) curve method for discriminating patients with TRD from those without TRD.Serum cortisol, C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) levels were significantly higher in the non-TRD and TRD groups than in the control group. Moreover, serum cortisol, CRP, TNF-α, and IL-6 levels in the TRD group were significantly lower than those in the non-TRD group. Furthermore, serum nesfatin-1 levels in the non-TRD group were significantly lower than those in the control and TRD groups, while the serum IL-1β levels in the non-TRD group were significantly higher than those in the control and TRD groups. Additionally, an ROC analysis revealed an area under the curve (AUC) of 0.929 for the combination of nesfatin-1 and IL-1β and an AUC of 0.956 for the combination of cortisol, nesfatin-1, and IL-1β in discriminating elderly patients with TRD from those without non-TRD.Serum cortisol, nesfatin-1, and IL-1β may be potential diagnostic biomarkers for discriminating elderly patients with TRD from those without TRD." @default.
• W4224254907 created "2022-04-26" @default.
• W4224254907 creator A5008281871 @default.
• W4224254907 creator A5016359586 @default.
• W4224254907 creator A5020819058 @default.
• W4224254907 creator A5048423015 @default.
• W4224254907 creator A5059086028 @default.
• W4224254907 creator A5080243567 @default.
• W4224254907 creator A5085836753 @default.
• W4224254907 date "2022-04-01" @default.
• W4224254907 modified "2023-10-14" @default.
• W4224254907 title "Serum Cortisol, Nesfatin-1, and IL-1β: Potential Diagnostic Biomarkers in Elderly Patients with Treatment-Resistant Depression" @default.
• W4224254907 cites W1052460703 @default.
• W4224254907 cites W1571066502 @default.
• W4224254907 cites W1601887224 @default.
• W4224254907 cites W1657789036 @default.
• W4224254907 cites W1922605075 @default.
• W4224254907 cites W1975588273 @default.
• W4224254907 cites W1985438873 @default.
• W4224254907 cites W2003982930 @default.
• W4224254907 cites W2006406307 @default.
• W4224254907 cites W2006640164 @default.
• W4224254907 cites W2012717246 @default.
• W4224254907 cites W2016292245 @default.
• W4224254907 cites W2026131598 @default.
• W4224254907 cites W2032402754 @default.
• W4224254907 cites W2042982960 @default.
• W4224254907 cites W2090213741 @default.
• W4224254907 cites W2092669597 @default.
• W4224254907 cites W2098667423 @default.
• W4224254907 cites W2104345615 @default.
• W4224254907 cites W2104960492 @default.
• W4224254907 cites W2128149456 @default.
• W4224254907 cites W2132086610 @default.
• W4224254907 cites W2132324173 @default.
• W4224254907 cites W2133699858 @default.
• W4224254907 cites W2141510372 @default.
• W4224254907 cites W2145586396 @default.
• W4224254907 cites W2170226754 @default.
• W4224254907 cites W2280318158 @default.
• W4224254907 cites W2512630553 @default.
• W4224254907 cites W2791081172 @default.
• W4224254907 cites W2800706434 @default.
• W4224254907 cites W2800735330 @default.
• W4224254907 cites W2803952783 @default.
• W4224254907 cites W2804087978 @default.
• W4224254907 cites W2806433220 @default.
• W4224254907 cites W2886676544 @default.
• W4224254907 cites W2896240451 @default.
• W4224254907 cites W2897839920 @default.
• W4224254907 cites W2899591457 @default.
• W4224254907 cites W2901476334 @default.
• W4224254907 cites W2905038391 @default.
• W4224254907 cites W2910864350 @default.
• W4224254907 cites W2916226351 @default.
• W4224254907 cites W2945666228 @default.
• W4224254907 cites W2949818647 @default.
• W4224254907 cites W2966002982 @default.
• W4224254907 cites W2987995124 @default.
• W4224254907 cites W3009174026 @default.
• W4224254907 cites W3011946288 @default.
• W4224254907 cites W3012747301 @default.
• W4224254907 cites W3013145591 @default.
• W4224254907 cites W3023505511 @default.
• W4224254907 cites W3025889317 @default.
• W4224254907 cites W3034012503 @default.
• W4224254907 cites W3037006406 @default.
• W4224254907 cites W3106477131 @default.
• W4224254907 cites W3110521603 @default.
• W4224254907 cites W3113930709 @default.
• W4224254907 cites W3141564337 @default.
• W4224254907 cites W4226205528 @default.
• W4224254907 doi "https://doi.org/10.2147/cia.s361459" @default.
• W4224254907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35480963" @default.
• W4224254907 hasPublicationYear "2022" @default.
• W4224254907 type Work @default.
• W4224254907 citedByCount "4" @default.
• W4224254907 countsByYear W42242549072022 @default.
• W4224254907 countsByYear W42242549072023 @default.
• W4224254907 crossrefType "journal-article" @default.
• W4224254907 hasAuthorship W4224254907A5008281871 @default.
• W4224254907 hasAuthorship W4224254907A5016359586 @default.
• W4224254907 hasAuthorship W4224254907A5020819058 @default.
• W4224254907 hasAuthorship W4224254907A5048423015 @default.
• W4224254907 hasAuthorship W4224254907A5059086028 @default.
• W4224254907 hasAuthorship W4224254907A5080243567 @default.
• W4224254907 hasAuthorship W4224254907A5085836753 @default.
• W4224254907 hasBestOaLocation W42242549071 @default.
• W4224254907 hasConcept C11988809 @default.
• W4224254907 hasConcept C126322002 @default.
• W4224254907 hasConcept C139719470 @default.
• W4224254907 hasConcept C143998085 @default.
• W4224254907 hasConcept C162324750 @default.
• W4224254907 hasConcept C17991360 @default.
• W4224254907 hasConcept C2776867660 @default.
• W4224254907 hasConcept C2777342061 @default.
• W4224254907 hasConcept C2778690821 @default.
• W4224254907 hasConcept C2779144063 @default.

• next