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- W4224255540 endingPage "119499" @default.
- W4224255540 startingPage "119499" @default.
- W4224255540 abstract "As an important transcription factor, c-Jun could upregulate growth factors expression in Schwann cells (SCs). Arginine-Glycine-Aspartate (RGD)-functionalized chitosan-graft-polyethyleneimine (RCP) gene vectors were prepared through the maleic anhydride & the carbodiimide methods, and electrostatically bound with c-Jun plasmids (pJUN), finally loaded on poly-L-lactic acid/silk fibroin parallel fiber films to fabricate nerve scaffold (RCP/pJUN-PSPF@PGA), which could locally deliver c-Jun plasmids into SCs via the mediation of RGD peptides, and upregulate the expression of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in SCs. After the scaffold was bridged in sciatic nerve defect, the delivery of c-Jun plasmids from RCP/pJUN-PSPF@PGA facilitated SCs to sustain the expressions of NGF, BDNF and vascular endothelial growth factor in the injury field, promoting myelination, axonal growth and microvascular generation and nerve regeneration, muscle reinnervation and functional recovery. These results suggested that RCP/pDNA-PSPF@PGA, as an effective gene delivery platform, could provide a local gene therapy to improve nerve regeneration." @default.
- W4224255540 created "2022-04-26" @default.
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- W4224255540 date "2022-08-01" @default.
- W4224255540 modified "2023-10-13" @default.
- W4224255540 title "Gene delivery of chitosan-graft-polyethyleneimine vectors loaded on scaffolds for nerve regeneration" @default.
- W4224255540 cites W1217626775 @default.
- W4224255540 cites W1964415483 @default.
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- W4224255540 cites W1970853504 @default.
- W4224255540 cites W1972243157 @default.
- W4224255540 cites W1972381874 @default.
- W4224255540 cites W1972545546 @default.
- W4224255540 cites W1977268622 @default.
- W4224255540 cites W1978917300 @default.
- W4224255540 cites W1980880341 @default.
- W4224255540 cites W1985525878 @default.
- W4224255540 cites W1990831361 @default.
- W4224255540 cites W1993561446 @default.
- W4224255540 cites W1994748285 @default.
- W4224255540 cites W1997246078 @default.
- W4224255540 cites W1999800789 @default.
- W4224255540 cites W2000130670 @default.
- W4224255540 cites W2004198454 @default.
- W4224255540 cites W2008033906 @default.
- W4224255540 cites W2013303704 @default.
- W4224255540 cites W2019038143 @default.
- W4224255540 cites W2020043003 @default.
- W4224255540 cites W2023357069 @default.
- W4224255540 cites W2026172660 @default.
- W4224255540 cites W2066567696 @default.
- W4224255540 cites W2069733372 @default.
- W4224255540 cites W2071083599 @default.
- W4224255540 cites W2084252835 @default.
- W4224255540 cites W2086848733 @default.
- W4224255540 cites W2088608292 @default.
- W4224255540 cites W2107278930 @default.
- W4224255540 cites W2110711342 @default.
- W4224255540 cites W2120692644 @default.
- W4224255540 cites W2140306359 @default.
- W4224255540 cites W2155800892 @default.
- W4224255540 cites W2260846512 @default.
- W4224255540 cites W2473509027 @default.
- W4224255540 cites W2532261996 @default.
- W4224255540 cites W2561006928 @default.
- W4224255540 cites W2727482182 @default.
- W4224255540 cites W2736295016 @default.
- W4224255540 cites W2740857127 @default.
- W4224255540 cites W2749185650 @default.
- W4224255540 cites W2752808499 @default.
- W4224255540 cites W2762894893 @default.
- W4224255540 cites W2783339065 @default.
- W4224255540 cites W2791923263 @default.
- W4224255540 cites W2798076349 @default.
- W4224255540 cites W2805266125 @default.
- W4224255540 cites W2806922678 @default.
- W4224255540 cites W2892057033 @default.
- W4224255540 cites W2892344177 @default.
- W4224255540 cites W2898451159 @default.
- W4224255540 cites W2900610791 @default.
- W4224255540 cites W2906657810 @default.
- W4224255540 cites W2913212173 @default.
- W4224255540 cites W2954838189 @default.
- W4224255540 cites W2960931384 @default.
- W4224255540 cites W2991581820 @default.
- W4224255540 cites W3010409416 @default.
- W4224255540 cites W3012261218 @default.
- W4224255540 cites W3016003439 @default.
- W4224255540 cites W3026893336 @default.
- W4224255540 cites W3028672506 @default.
- W4224255540 cites W3048476253 @default.
- W4224255540 cites W3087079837 @default.
- W4224255540 cites W3126837796 @default.
- W4224255540 cites W3127231367 @default.
- W4224255540 cites W3135188335 @default.
- W4224255540 cites W3165416619 @default.
- W4224255540 cites W3212956150 @default.
- W4224255540 cites W4233394827 @default.
- W4224255540 doi "https://doi.org/10.1016/j.carbpol.2022.119499" @default.
- W4224255540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35550777" @default.
- W4224255540 hasPublicationYear "2022" @default.
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