Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224255725> ?p ?o ?g. }
- W4224255725 endingPage "64" @default.
- W4224255725 startingPage "39" @default.
- W4224255725 abstract "This chapter focuses on factors influencing regional epithelial permeation of drugs related especially to transporters. It highlights the important key messages as regard to modified-release formulations. Drug absorption for ionizable drugs is determined by the pH in the region of intended release. Uptake and efflux transporters expressed in the gastrointestinal tract modulate the absorption of several drugs. Uptake transporters are more likely to act in synergy with other enzymes whose regional distribution is similar to CYP3A4, such as glucuronosyltransferases, sulfotransferases, and glutathione-S-transferases. The impact of the interplay between drug transport and metabolism on regional absorption can also be studied with perfusion techniques using cannulated in situ or isolated ex vivo intestinal regions in the rat. Drug–drug interactions can lead to changed systemic exposure, resulting in variations in drug response of the coadministered drug/s as well as safety concerns especially for low therapeutic index drugs." @default.
- W4224255725 created "2022-04-26" @default.
- W4224255725 creator A5006075771 @default.
- W4224255725 creator A5025614477 @default.
- W4224255725 creator A5044395241 @default.
- W4224255725 creator A5068697899 @default.
- W4224255725 creator A5078756591 @default.
- W4224255725 creator A5082362716 @default.
- W4224255725 creator A5084198678 @default.
- W4224255725 date "2022-04-08" @default.
- W4224255725 modified "2023-10-12" @default.
- W4224255725 title "Intestinal Epithelium and Drug Transporters" @default.
- W4224255725 cites W105680442 @default.
- W4224255725 cites W113869861 @default.
- W4224255725 cites W142069827 @default.
- W4224255725 cites W1494088772 @default.
- W4224255725 cites W1498305210 @default.
- W4224255725 cites W1499768710 @default.
- W4224255725 cites W1499935265 @default.
- W4224255725 cites W1501945432 @default.
- W4224255725 cites W15077932 @default.
- W4224255725 cites W1517652134 @default.
- W4224255725 cites W1537274319 @default.
- W4224255725 cites W1542164875 @default.
- W4224255725 cites W1560709301 @default.
- W4224255725 cites W1567322443 @default.
- W4224255725 cites W1571401550 @default.
- W4224255725 cites W1572461322 @default.
- W4224255725 cites W1578896110 @default.
- W4224255725 cites W1579212850 @default.
- W4224255725 cites W1599070850 @default.
- W4224255725 cites W1600472674 @default.
- W4224255725 cites W1601678499 @default.
- W4224255725 cites W1724778664 @default.
- W4224255725 cites W1780754232 @default.
- W4224255725 cites W1786595753 @default.
- W4224255725 cites W1870415320 @default.
- W4224255725 cites W1964471078 @default.
- W4224255725 cites W1964515781 @default.
- W4224255725 cites W1966178564 @default.
- W4224255725 cites W1966267502 @default.
- W4224255725 cites W1966752296 @default.
- W4224255725 cites W1966900139 @default.
- W4224255725 cites W1966960575 @default.
- W4224255725 cites W1970211838 @default.
- W4224255725 cites W1970359870 @default.
- W4224255725 cites W1972516058 @default.
- W4224255725 cites W1972523776 @default.
- W4224255725 cites W1973840608 @default.
- W4224255725 cites W1974574813 @default.
- W4224255725 cites W1974774407 @default.
- W4224255725 cites W1974800692 @default.
- W4224255725 cites W1975921630 @default.
- W4224255725 cites W1977244805 @default.
- W4224255725 cites W1978211222 @default.
- W4224255725 cites W1980170993 @default.
- W4224255725 cites W1980171805 @default.
- W4224255725 cites W1984558185 @default.
- W4224255725 cites W1984814708 @default.
- W4224255725 cites W1985426192 @default.
- W4224255725 cites W1985775644 @default.
- W4224255725 cites W1986182628 @default.
- W4224255725 cites W1986348861 @default.
- W4224255725 cites W1987104113 @default.
- W4224255725 cites W1987167904 @default.
- W4224255725 cites W1988703513 @default.
- W4224255725 cites W1989471847 @default.
- W4224255725 cites W1990291419 @default.
- W4224255725 cites W1990359955 @default.
- W4224255725 cites W1995238258 @default.
- W4224255725 cites W1998741645 @default.
- W4224255725 cites W1998776502 @default.
- W4224255725 cites W2001488324 @default.
- W4224255725 cites W2002200747 @default.
- W4224255725 cites W2003556240 @default.
- W4224255725 cites W2005966771 @default.
- W4224255725 cites W2006973274 @default.
- W4224255725 cites W2008694655 @default.
- W4224255725 cites W2009170641 @default.
- W4224255725 cites W2009537932 @default.
- W4224255725 cites W2014164434 @default.
- W4224255725 cites W2014515114 @default.
- W4224255725 cites W2015500397 @default.
- W4224255725 cites W2015722911 @default.
- W4224255725 cites W2016011381 @default.
- W4224255725 cites W2017678349 @default.
- W4224255725 cites W2019952326 @default.
- W4224255725 cites W2020853269 @default.
- W4224255725 cites W2021399896 @default.
- W4224255725 cites W2021805817 @default.
- W4224255725 cites W2022073300 @default.
- W4224255725 cites W2022302468 @default.
- W4224255725 cites W2022713088 @default.
- W4224255725 cites W2022885537 @default.
- W4224255725 cites W2023060419 @default.
- W4224255725 cites W2023522980 @default.
- W4224255725 cites W2023880368 @default.
- W4224255725 cites W2026222539 @default.