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• W4224255796 abstract "We appreciate Professor Cravedi’s interest 1 Cravedi P. Role of cyclooxygenase-2 in macrophage subsets during kidney repair. Kidney Int. 2022;101:1084. Google Scholar in our recent study 2 Pan Y. Cao S. Terker A.S. et al. Myeloid cyclooxygenase-2/prostaglandin E2/E-type prostanoid receptor 4 promotes transcription factor MafB-dependent inflammatory resolution in acute kidney injury. Kidney Int. 2022; 101: 79-91 Google Scholar and the helpful suggestions for our future research. CD11b+Ly6clow monocytes, also known as nonclassical monocytes or patrolling monocytes, have received considerable attention in recent years because they may be associated with scavenging microparticles and necrotic debris and injury repair. 3 Carlin L.M. Stamatiades E.G. Auffray C. et al. Nr4a1-dependent Ly6C(low) monocytes monitor endothelial cells and orchestrate their disposal. Cell. 2013; 153: 362-375 Google Scholar ,4 Narasimhan P.B. Marcovecchio P. Hamers A.A.J. Hedrick C.C. Nonclassical monocytes in health and disease. Annu Rev Immunol. 2019; 37: 439-456 Google Scholar In our study, we noticed that CD11b Cre: COX-2f/f mice increased CD11b+Ly6Chigh monocyte recruitment after ischemia-reperfusion injury. We hypothesize that cyclooxygenase-2 (COX-2) might play an essential role in maintaining the function of Ly6Clow monocytes, which may be another new potential mechanism to explain the COX-2–mediated efferocytosis and resolution phenotype. In further studies, we plan to utilize single-cell sequencing to explore the macrophage/monocyte subset(s) primarily responsible for COX-2–induced kidney recovery, with the expectation it will help us better understand the role of macrophage/monocyte COX-2 in acute kidney injury. Myeloid cyclooxygenase-2/prostaglandin E2/E-type prostanoid receptor 4 promotes transcription factor MafB-dependent inflammatory resolution in acute kidney injuryKidney InternationalVol. 101Issue 1PreviewFollowing acute injury to the kidney, macrophages play an important role in recovery of functional and structural integrity, but organ fibrosis and progressive functional decline occur with incomplete recovery. Pro-resolving macrophages are characterized by increased cyclooxygenase 2 (COX-2) expression and this expression was selectively increased in kidney macrophages following injury and myeloid-specific COX-2 deletion inhibited recovery. Deletion of the myeloid prostaglandin E2 (PGE2) receptor, E-type prostanoid receptor 4 (EP4), mimicked effects seen with myeloid COX-2-/- deletion. Full-Text PDF Role of cyclooxygenase-2 in macrophage subsets during kidney repairKidney InternationalVol. 101Issue 5PreviewWe congratulate Pan et al. for their beautiful study published in Kidney International.1 The work indicates that the cyclooxygenase-2 pathway in myeloid cells is a critical mediator of the balance between tissue injury and repair following acute kidney injury (AKI). The elegantly designed experiments are important, as they shed light on the still largely unknown molecular mechanisms that orchestrate the immune response in AKI and in the transition to chronic kidney injury. However, some additional analyses of the generated data might help further understanding the dynamic role of macrophages in this condition. Full-Text PDF" @default.
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