FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224256140> ?p ?o ?g. }

• W4224256140 endingPage "172" @default.
• W4224256140 startingPage "159" @default.
• W4224256140 abstract "Platelet-activating factor (PAF) is an important mediator of allergic reactions such as anaphylaxis, and is therefore an anaphylactic drug target. Previously, we found marked inhibition of anaphylactic reactions by a synthetic N-terminally biotinylated peptide (BP21) capable of specifically binding PAF. In this study, we investigated the effects of 10-hydroxy-2-decenoic acid (10-HDA) and various peptides derived from royalisin, both of which are widely known to be major components of royal jelly from honeybees, on PAF/histamine-induced rat hind-paw edema and mouse anaphylactic hypothermia. In a rat model of hind paw edema, both 10-HDA (50 nmol/paw) and a royalisin-related N-terminally biotinylated peptide, Biotin-RL-Y11, (10 nmol/paw) markedly inhibited PAF-induced paw edema by 95.5±5.0% and 71.9±9.9%, respectively. 10-HDA also inhibited histamine-induced paw edema by 42.7±19.2%. In contrast, three peptides with N-terminal HDA modifications, namely 10-HDA-RL-Y11, 10-HDA-RL-R11, and 10-HDA-P21 only weakly inhibited PAF-induced paw edema. In a mouse model of anaphylaxis, the administration of 10-HDA (100-1000 nmol/mouse) and/or Biotin-RL-Y11 (100 nmol/mouse) showed the inhibitory effects on anaphylactic hypothermia. These results suggest that both 10-HDA and Biotin-RL-Y11 may exert an anti-anaphylactic effect targeting PAF." @default.
• W4224256140 created "2022-04-26" @default.
• W4224256140 creator A5003076884 @default.
• W4224256140 creator A5010163861 @default.
• W4224256140 creator A5037257519 @default.
• W4224256140 creator A5056752529 @default.
• W4224256140 creator A5080424534 @default.
• W4224256140 date "2022-03-04" @default.
• W4224256140 modified "2023-10-16" @default.
• W4224256140 title "Royal Jelly-derived Two Compounds, 10-hydroxy-2-decenoic acid and a Biotinylated Royalisin-related Peptide, Alleviate Anaphylactic Hypothermia <i>In vivo</i>" @default.
• W4224256140 cites W1515010604 @default.
• W4224256140 cites W1963128175 @default.
• W4224256140 cites W1977784192 @default.
• W4224256140 cites W1998090585 @default.
• W4224256140 cites W2005007286 @default.
• W4224256140 cites W2012645636 @default.
• W4224256140 cites W2013482517 @default.
• W4224256140 cites W2019164272 @default.
• W4224256140 cites W2023036251 @default.
• W4224256140 cites W2044751201 @default.
• W4224256140 cites W2047758829 @default.
• W4224256140 cites W2048983224 @default.
• W4224256140 cites W2073627522 @default.
• W4224256140 cites W2074709136 @default.
• W4224256140 cites W2088929443 @default.
• W4224256140 cites W2089018891 @default.
• W4224256140 cites W2097022788 @default.
• W4224256140 cites W2113635597 @default.
• W4224256140 cites W2122633614 @default.
• W4224256140 cites W2131123416 @default.
• W4224256140 cites W2137938637 @default.
• W4224256140 cites W2153912688 @default.
• W4224256140 cites W2155585095 @default.
• W4224256140 cites W2282197705 @default.
• W4224256140 cites W2467179186 @default.
• W4224256140 cites W2612975245 @default.
• W4224256140 cites W2684743415 @default.
• W4224256140 cites W2744715029 @default.
• W4224256140 cites W276534841 @default.
• W4224256140 cites W2794682584 @default.
• W4224256140 cites W2801432904 @default.
• W4224256140 cites W2913560607 @default.
• W4224256140 cites W2955897201 @default.
• W4224256140 cites W2961126825 @default.
• W4224256140 cites W2961523236 @default.
• W4224256140 cites W2991658842 @default.
• W4224256140 cites W3000014045 @default.
• W4224256140 cites W3085236747 @default.
• W4224256140 cites W3128551684 @default.
• W4224256140 cites W3134831990 @default.
• W4224256140 cites W4229620302 @default.
• W4224256140 cites W4301803635 @default.
• W4224256140 doi "https://doi.org/10.1080/22311866.2022.2034530" @default.
• W4224256140 hasPublicationYear "2022" @default.
• W4224256140 type Work @default.
• W4224256140 citedByCount "0" @default.
• W4224256140 crossrefType "journal-article" @default.
• W4224256140 hasAuthorship W4224256140A5003076884 @default.
• W4224256140 hasAuthorship W4224256140A5010163861 @default.
• W4224256140 hasAuthorship W4224256140A5037257519 @default.
• W4224256140 hasAuthorship W4224256140A5056752529 @default.
• W4224256140 hasAuthorship W4224256140A5080424534 @default.
• W4224256140 hasConcept C1122143 @default.
• W4224256140 hasConcept C126322002 @default.
• W4224256140 hasConcept C150903083 @default.
• W4224256140 hasConcept C185592680 @default.
• W4224256140 hasConcept C203014093 @default.
• W4224256140 hasConcept C204628709 @default.
• W4224256140 hasConcept C207001950 @default.
• W4224256140 hasConcept C207480886 @default.
• W4224256140 hasConcept C2775933838 @default.
• W4224256140 hasConcept C2777390192 @default.
• W4224256140 hasConcept C2778027074 @default.
• W4224256140 hasConcept C2778204606 @default.
• W4224256140 hasConcept C2779281246 @default.
• W4224256140 hasConcept C2780886150 @default.
• W4224256140 hasConcept C31903555 @default.
• W4224256140 hasConcept C55493867 @default.
• W4224256140 hasConcept C71924100 @default.
• W4224256140 hasConcept C86803240 @default.
• W4224256140 hasConcept C98274493 @default.
• W4224256140 hasConceptScore W4224256140C1122143 @default.
• W4224256140 hasConceptScore W4224256140C126322002 @default.
• W4224256140 hasConceptScore W4224256140C150903083 @default.
• W4224256140 hasConceptScore W4224256140C185592680 @default.
• W4224256140 hasConceptScore W4224256140C203014093 @default.
• W4224256140 hasConceptScore W4224256140C204628709 @default.
• W4224256140 hasConceptScore W4224256140C207001950 @default.
• W4224256140 hasConceptScore W4224256140C207480886 @default.
• W4224256140 hasConceptScore W4224256140C2775933838 @default.
• W4224256140 hasConceptScore W4224256140C2777390192 @default.
• W4224256140 hasConceptScore W4224256140C2778027074 @default.
• W4224256140 hasConceptScore W4224256140C2778204606 @default.
• W4224256140 hasConceptScore W4224256140C2779281246 @default.
• W4224256140 hasConceptScore W4224256140C2780886150 @default.
• W4224256140 hasConceptScore W4224256140C31903555 @default.
• W4224256140 hasConceptScore W4224256140C55493867 @default.
• W4224256140 hasConceptScore W4224256140C71924100 @default.

• next