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- W4224256861 abstract "Sex determination and differentiation in reptiles are complex. In the model species, Pogona vitticeps , high incubation temperature can cause male to female sex reversal. To elucidate the epigenetic mechanisms of thermolabile sex, we used an unbiased genome-wide assessment of intron retention during sex reversal. The previously implicated chromatin modifiers ( jarid2 and kdm6b ) were two of three genes to display sex reversal–specific intron retention. In these species, embryonic intron retention resulting in C-terminally truncated jarid2 and kdm6b isoforms consistently occurs at low temperatures. High-temperature sex reversal is uniquely characterized by a high prevalence of N-terminally truncated isoforms of jarid2 and kdm6b , which are not present at low temperatures, or in two other reptiles with temperature-dependent sex determination. This work verifies that chromatin-modifying genes are involved in highly conserved temperature responses and can also be transcribed into isoforms with new sex-determining roles." @default.
- W4224256861 created "2022-04-26" @default.
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- W4224256861 date "2022-04-22" @default.
- W4224256861 modified "2023-10-07" @default.
- W4224256861 title "Truncated <i>jarid2</i> and <i>kdm6b</i> transcripts are associated with temperature-induced sex reversal during development in a dragon lizard" @default.
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- W4224256861 doi "https://doi.org/10.1126/sciadv.abk0275" @default.
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