FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224257061> ?p ?o ?g. }

• W4224257061 endingPage "620" @default.
• W4224257061 startingPage "597" @default.
• W4224257061 abstract "Cerebral vasospasm (VSP) is the leading risk factor of neurological deterioration (i.e., delayed cerebral ischemia [DCI] and cerebral infarction) after aneurysmal subarachnoid hemorrhage (aSAH) and a cause of morbidity and mortality. The objective of this systematic literature review is to summarize the economic and humanistic burden of VSP and its related complications after aSAH. A predefined protocol was designed, and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Systematic searches were conducted in MEDLINE, Embase, and Cochrane (in January 2021) to identify studies reporting economic and/or humanistic (i.e., health-related quality of life [HRQoL]) outcomes for patients with asymptomatic and symptomatic VSP after aSAH. Related conferences and additional sources were searched manually. Dual screening, data extraction, and qualitative analysis were conducted. Of 3818 abstracts identified for review, 43 full-text articles representing 42 single studies met the inclusion criteria and were included. Most studies (33) were observational; nine were randomized clinical trials (RCTs). Economic outcomes were reported in 31 studies, and alongside HRQoL outcomes in 4 studies; 7 studies reported HRQoL outcomes only. Forty studies were conducted in single countries, while only 2 RCTs were conducted in multiple countries. Patients diagnosed with VSP or DCI spent between 2.1 and 7.4 days longer in intensive care and between 4.7 and 17 days longer in hospital (total) compared with patients without VSP or DCI. A significantly higher cost burden of US$33,945 (2021 £26,712) was identified for patients with VSP and £9370 (2021 £13,733) for patients with DCI compared with patients without. Patients with DCI were also disadvantaged by being employed for 62 fewer days (during 24-month follow-up), with an estimated mean cost of £3821 (2021 £5600) for days off work. Poor HRQoL was associated with ≥ 1 days with VSP symptoms (odds ratio [OR]: 2.8, 95% confidence interval [CI]: 1.4–5.3), symptomatic VSP (OR: 1.9, 95% CI: 1.0–3.6), and DCI (OR: 2.3, 95% CI: 1.3–4.2), although this was not consistent across all studies. Symptomatic VSP and DCI were identified as significant risk factors for depressed mood (OR: 2.2, 95% CI: 1.0–4.9) and global cognitive impairment (OR: 2.3) at 12 months, respectively. The severity of VSP was a critical predictor of post-aSAH economic and humanistic burden. Similar trends in economic and humanistic burden were identified in the general aSAH patient population. Study design and patient heterogeneity precluded direct metaanalysis of the results. A substantial direct and indirect economic burden is linked to VSP and its related complications after aSAH. Although limited evidence was identified for humanistic burden, these patients seem to suffer from poor HRQoL with long-lasting burden. Overall, there is an urgent need to understand better the concept of “burden of illness” of VSP and its related complications after aSAH. Aneurysmal subarachnoid hemorrhage is a sudden, life-threatening emergency caused by bleeding in the subarachnoid space between the brain and skull. Vasospasm of the arteries surrounding the hemorrhage occurs in most patients and may lead to permanent brain damage. This study summarizes the published literature to describe the burden that patients may experience due to vasospasm and its related complications after aneurysmal subarachnoid hemorrhage, focusing on financial and life quality aspects. We show that the burden of vasospasm, and its related complications, is huge. Patients often experience reduced quality of life due to their poor health and are more likely to suffer from depression and intellectual impairment. There is also a substantial financial burden linked to vasospasm and its related complications, driven by the need for more intensive care, hospitalization, and higher investigative costs associated with the treatment and management of these patients. In addition, days off work and unemployment can cause a substantial indirect financial burden. Our study highlights the need for additional research to understand further the “burden of illness” of vasospasm and its related complications after aneurysmal subarachnoid hemorrhage." @default.
• W4224257061 created "2022-04-26" @default.
• W4224257061 creator A5003412990 @default.
• W4224257061 creator A5030131103 @default.
• W4224257061 creator A5044352141 @default.
• W4224257061 creator A5067817895 @default.
• W4224257061 creator A5081828204 @default.
• W4224257061 creator A5086694459 @default.
• W4224257061 date "2022-04-20" @default.
• W4224257061 modified "2023-09-26" @default.
• W4224257061 title "Economic and Humanistic Burden of Cerebral Vasospasm and Its Related Complications after Aneurysmal Subarachnoid Hemorrhage: A Systematic Literature Review" @default.
• W4224257061 cites W115191644 @default.
• W4224257061 cites W1578396164 @default.
• W4224257061 cites W1973744968 @default.
• W4224257061 cites W1977211256 @default.
• W4224257061 cites W1980107660 @default.
• W4224257061 cites W1981284141 @default.
• W4224257061 cites W1988707622 @default.
• W4224257061 cites W1992794952 @default.
• W4224257061 cites W1993408195 @default.
• W4224257061 cites W1995720942 @default.
• W4224257061 cites W2005769855 @default.
• W4224257061 cites W2033333626 @default.
• W4224257061 cites W2034650743 @default.
• W4224257061 cites W2038680419 @default.
• W4224257061 cites W2046454713 @default.
• W4224257061 cites W2052223963 @default.
• W4224257061 cites W2060752639 @default.
• W4224257061 cites W2062877315 @default.
• W4224257061 cites W2076849259 @default.
• W4224257061 cites W2078685189 @default.
• W4224257061 cites W2079003983 @default.
• W4224257061 cites W2082657386 @default.
• W4224257061 cites W2090439908 @default.
• W4224257061 cites W2090972551 @default.
• W4224257061 cites W2101988458 @default.
• W4224257061 cites W2111062482 @default.
• W4224257061 cites W2120346993 @default.
• W4224257061 cites W2128360580 @default.
• W4224257061 cites W2131195151 @default.
• W4224257061 cites W2136265514 @default.
• W4224257061 cites W2137299577 @default.
• W4224257061 cites W2144338223 @default.
• W4224257061 cites W2148710266 @default.
• W4224257061 cites W2150982420 @default.
• W4224257061 cites W2157006832 @default.
• W4224257061 cites W2157540829 @default.
• W4224257061 cites W2161179379 @default.
• W4224257061 cites W2317489972 @default.
• W4224257061 cites W2330215393 @default.
• W4224257061 cites W2520731555 @default.
• W4224257061 cites W2571918371 @default.
• W4224257061 cites W2601884045 @default.
• W4224257061 cites W2765157924 @default.
• W4224257061 cites W2765679704 @default.
• W4224257061 cites W2766783053 @default.
• W4224257061 cites W2784034563 @default.
• W4224257061 cites W2793775417 @default.
• W4224257061 cites W2797801554 @default.
• W4224257061 cites W2801976162 @default.
• W4224257061 cites W2909576376 @default.
• W4224257061 cites W2910975756 @default.
• W4224257061 cites W2946159340 @default.
• W4224257061 cites W2977606917 @default.
• W4224257061 cites W2984772913 @default.
• W4224257061 cites W2993055172 @default.
• W4224257061 cites W2999081724 @default.
• W4224257061 cites W3006930476 @default.
• W4224257061 cites W3013238931 @default.
• W4224257061 cites W3043541832 @default.
• W4224257061 cites W3081385456 @default.
• W4224257061 cites W3092163022 @default.
• W4224257061 cites W3092269078 @default.
• W4224257061 cites W3094059359 @default.
• W4224257061 cites W3141256924 @default.
• W4224257061 cites W4232294043 @default.
• W4224257061 cites W4235117781 @default.
• W4224257061 doi "https://doi.org/10.1007/s40120-022-00348-6" @default.
• W4224257061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35441974" @default.
• W4224257061 hasPublicationYear "2022" @default.
• W4224257061 type Work @default.
• W4224257061 citedByCount "8" @default.
• W4224257061 countsByYear W42242570612022 @default.
• W4224257061 countsByYear W42242570612023 @default.
• W4224257061 crossrefType "journal-article" @default.
• W4224257061 hasAuthorship W4224257061A5003412990 @default.
• W4224257061 hasAuthorship W4224257061A5030131103 @default.
• W4224257061 hasAuthorship W4224257061A5044352141 @default.
• W4224257061 hasAuthorship W4224257061A5067817895 @default.
• W4224257061 hasAuthorship W4224257061A5081828204 @default.
• W4224257061 hasAuthorship W4224257061A5086694459 @default.
• W4224257061 hasBestOaLocation W42242570611 @default.
• W4224257061 hasConcept C126322002 @default.
• W4224257061 hasConcept C168563851 @default.
• W4224257061 hasConcept C17744445 @default.
• W4224257061 hasConcept C177713679 @default.
• W4224257061 hasConcept C187212893 @default.
• W4224257061 hasConcept C189708586 @default.

• next