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- W4224257455 abstract "Hepatocellular carcinoma (HCC) is the sixth most common type of cancer and accounts for ~90% of cases, with an approximated incidence of >1 million cases by 2025. Currently, the backbone of HCC therapy is the oral multi-kinase inhibitor, Sorafenib, which consists of a Pyridine heterocycle ring system. This review highlights the introspective characteristics of seven anticancer drugs of heterocyclic nature against HCC along with their structural activity relationships and molecular targets.Literature collection was performed using PubMed, Google Scholar, SCOPUS, and Cross ref. Additional information was taken from the official website of the FDA and GLOBOCAN. Key findings/ Results: Based on the available literature, approved heterocyclic compounds show promising results against HCC, including Sorafenib (Pyridine), Regorafenib (Pyridine), Lenvatinib (Quinoline), Cabozantinib (Quinoline), Gemcitabine (Pyrimidine), 5-Fluorouracil (Pyrimidine)and Capecitabine (Pyrimidine), their mechanism of action and key aspects regarding its structural activity were included in the review.Heterocyclic compounds represent almost two-thirds of the novel drugs approved by FDA between 2010 and 2020 against Cancer. This review summarizes the clinical relevance, mechanism of action, structural activity relationship, and challenges of the seven available anticancer drugs with heterocyclic ring systems against HCC." @default.
- W4224257455 created "2022-04-26" @default.
- W4224257455 creator A5000254483 @default.
- W4224257455 creator A5000391207 @default.
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- W4224257455 creator A5023941392 @default.
- W4224257455 creator A5037462434 @default.
- W4224257455 creator A5056118854 @default.
- W4224257455 date "2023-05-01" @default.
- W4224257455 modified "2023-09-29" @default.
- W4224257455 title "Decoding the Mechanism of Drugs of Heterocyclic Nature against Hepatocellular Carcinoma" @default.
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