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• W4224259413 endingPage "1514" @default.
• W4224259413 startingPage "1514" @default.
• W4224259413 abstract "Obesity is rapidly becoming an emerging disease in developing countries due to the Westernization of societies and lifestyle changes. This study evaluated the ameliorative effect of acidic heteropolysaccharides derived from Tremella fuciformis (TFPS) on high-fat diet (HFD; 34.9% fat)-induced obesity in mice. The TFPS exhibited high uronic acid content and high viscosity in water. The structural characteristics of TFPS showed that average molecular weight was 679 kDa, and the monosaccharide composition was galactose, glucose, fructose, xylose, fucose, and mannose at a ratio of 1.0:6.5:10.0:18.5:30.5:67.5. In an in vivo study, HFD-induced obese C57BL/6 mice were orally given a TFPS treatment at 1 and 2 g/kg of body weight for 8 weeks. The TFPS treatment significantly reduced features of obesity in the mice, namely weight gain, feed efficiency, body fat percentage, and serum cholesterol level and increased fecal lipid content, compared with mice fed an HFD with water. In addition, TFPS exhibited the inhibition of cholesterol micelles in vitro in a concentration-dependent manner. In conclusion, the TFPS treatment ameliorated the diet-induced obesity in the mice, presumably reducing fat absorption in the intestine by interfering with viscous TFPS." @default.
• W4224259413 created "2022-04-26" @default.
• W4224259413 creator A5025686879 @default.
• W4224259413 creator A5026912581 @default.
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• W4224259413 date "2022-04-08" @default.
• W4224259413 modified "2023-09-25" @default.
• W4224259413 title "Amelioration of Obesity in Mice Fed a High-Fat Diet with Uronic Acid–Rich Polysaccharides Derived from Tremella fuciformis" @default.
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• W4224259413 doi "https://doi.org/10.3390/polym14081514" @default.
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• W4224259413 hasPublicationYear "2022" @default.
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