Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224259417> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4224259417 endingPage "5" @default.
- W4224259417 startingPage "1" @default.
- W4224259417 abstract "Abstract Nearly one in five children with CHD is born with white matter injury that can be recognised on postnatal MRI by the presence of T1 hyperintense lesions. This pattern of white matter injury is known to portend poor neurodevelopmental outcomes, but the exact aetiology and histologic characterisation of these lesions have never been described. A fetal sheep was cannulated at gestational age 110 days onto a pumpless extracorporeal oxygenator via the umbilical vessels and supported in a fluid environment for 14.5 days. The fetus was supported under hypoxic conditions (mean oxygen delivery 16 ml/kg/day) to simulate the in utero conditions of CHD. At necropsy, the brain was fixed, imaged with MRI, and then stained to histologically identify areas of injury. Under hypoxemic in utero conditions, the fetus developed a T1 hyperintense lesion in its right frontal lobe. Histologically, this lesion was characterised by microvascular proliferation and astrocytosis without gliosis. These findings may provide valuable insight into the aetiology of white matter injury in neonates with CHD." @default.
- W4224259417 created "2022-04-26" @default.
- W4224259417 creator A5001790737 @default.
- W4224259417 creator A5012536194 @default.
- W4224259417 creator A5014432451 @default.
- W4224259417 creator A5016391982 @default.
- W4224259417 creator A5029190313 @default.
- W4224259417 creator A5038003666 @default.
- W4224259417 creator A5056885320 @default.
- W4224259417 creator A5076796950 @default.
- W4224259417 date "2022-04-19" @default.
- W4224259417 modified "2023-10-16" @default.
- W4224259417 title "Radiographic and histologic characterisation of white matter injury in a sheep model of CHD" @default.
- W4224259417 cites W1902838673 @default.
- W4224259417 cites W1996831127 @default.
- W4224259417 cites W2002403913 @default.
- W4224259417 cites W2040127962 @default.
- W4224259417 cites W2042862484 @default.
- W4224259417 cites W2105228597 @default.
- W4224259417 cites W2105478587 @default.
- W4224259417 cites W2120976691 @default.
- W4224259417 cites W2157799711 @default.
- W4224259417 cites W2320642633 @default.
- W4224259417 cites W2404081747 @default.
- W4224259417 cites W2609105226 @default.
- W4224259417 cites W2762662694 @default.
- W4224259417 cites W2801425348 @default.
- W4224259417 cites W2807852901 @default.
- W4224259417 cites W2908911486 @default.
- W4224259417 cites W2909028860 @default.
- W4224259417 cites W2922507670 @default.
- W4224259417 cites W2927056306 @default.
- W4224259417 cites W3091099880 @default.
- W4224259417 doi "https://doi.org/10.1017/s104795112200107x" @default.
- W4224259417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35438073" @default.
- W4224259417 hasPublicationYear "2022" @default.
- W4224259417 type Work @default.
- W4224259417 citedByCount "0" @default.
- W4224259417 crossrefType "journal-article" @default.
- W4224259417 hasAuthorship W4224259417A5001790737 @default.
- W4224259417 hasAuthorship W4224259417A5012536194 @default.
- W4224259417 hasAuthorship W4224259417A5014432451 @default.
- W4224259417 hasAuthorship W4224259417A5016391982 @default.
- W4224259417 hasAuthorship W4224259417A5029190313 @default.
- W4224259417 hasAuthorship W4224259417A5038003666 @default.
- W4224259417 hasAuthorship W4224259417A5056885320 @default.
- W4224259417 hasAuthorship W4224259417A5076796950 @default.
- W4224259417 hasConcept C126838900 @default.
- W4224259417 hasConcept C142724271 @default.
- W4224259417 hasConcept C143409427 @default.
- W4224259417 hasConcept C146638467 @default.
- W4224259417 hasConcept C172680121 @default.
- W4224259417 hasConcept C201614185 @default.
- W4224259417 hasConcept C204232928 @default.
- W4224259417 hasConcept C2777682930 @default.
- W4224259417 hasConcept C2778376644 @default.
- W4224259417 hasConcept C2779234561 @default.
- W4224259417 hasConcept C2780123866 @default.
- W4224259417 hasConcept C2781156865 @default.
- W4224259417 hasConcept C2781192897 @default.
- W4224259417 hasConcept C2908656565 @default.
- W4224259417 hasConcept C54355233 @default.
- W4224259417 hasConcept C71924100 @default.
- W4224259417 hasConcept C86803240 @default.
- W4224259417 hasConceptScore W4224259417C126838900 @default.
- W4224259417 hasConceptScore W4224259417C142724271 @default.
- W4224259417 hasConceptScore W4224259417C143409427 @default.
- W4224259417 hasConceptScore W4224259417C146638467 @default.
- W4224259417 hasConceptScore W4224259417C172680121 @default.
- W4224259417 hasConceptScore W4224259417C201614185 @default.
- W4224259417 hasConceptScore W4224259417C204232928 @default.
- W4224259417 hasConceptScore W4224259417C2777682930 @default.
- W4224259417 hasConceptScore W4224259417C2778376644 @default.
- W4224259417 hasConceptScore W4224259417C2779234561 @default.
- W4224259417 hasConceptScore W4224259417C2780123866 @default.
- W4224259417 hasConceptScore W4224259417C2781156865 @default.
- W4224259417 hasConceptScore W4224259417C2781192897 @default.
- W4224259417 hasConceptScore W4224259417C2908656565 @default.
- W4224259417 hasConceptScore W4224259417C54355233 @default.
- W4224259417 hasConceptScore W4224259417C71924100 @default.
- W4224259417 hasConceptScore W4224259417C86803240 @default.
- W4224259417 hasLocation W42242594171 @default.
- W4224259417 hasLocation W42242594172 @default.
- W4224259417 hasOpenAccess W4224259417 @default.
- W4224259417 hasPrimaryLocation W42242594171 @default.
- W4224259417 hasRelatedWork W107117702 @default.
- W4224259417 hasRelatedWork W1967934517 @default.
- W4224259417 hasRelatedWork W1982311446 @default.
- W4224259417 hasRelatedWork W2030333001 @default.
- W4224259417 hasRelatedWork W2041019882 @default.
- W4224259417 hasRelatedWork W2108023939 @default.
- W4224259417 hasRelatedWork W2108650698 @default.
- W4224259417 hasRelatedWork W2147556339 @default.
- W4224259417 hasRelatedWork W4224259417 @default.
- W4224259417 hasRelatedWork W4243498086 @default.
- W4224259417 isParatext "false" @default.
- W4224259417 isRetracted "false" @default.
- W4224259417 workType "article" @default.