Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224265899> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4224265899 abstract "Abstract Background: Several observational studies have revealed a positive or negative correlation between body size (BS) and glaucoma. However, the effect of BS on glaucoma remains unclear. Therefore, we studied BS causal association with glaucoma risk using Mendelian randomization (MR). Method: The Body Size was determined through anthropometric traits (ATs), such as body mass index (BMI), waist-to-hip ratio adjusted by body mass index (WHRadjBMI), waist-to-hip ratio (WHR), and waist circumference (WC). Association of single nucleotide polymorphisms (SNPs) with each AT and glaucoma were determined individually from the aggregated data of the Genetic Investigation of Anthropometric Traits (GIANT) consortium and the FinnGen study summary data (8591 cases with glaucoma and 210,201 controls). To explore the role of BS and glaucoma, a two-sample MR analysis was performed on genome-wide association study (GWAS) data. Besides, three MR methods (inverse variance weighted [IVW], weighted median, and MR-Egger regression) were used to get the whole causal estimate for multiple instrumental SNPs. Results: The odds ratio (OR) [95%confidence interval (CI)] for glaucoma risk per 1-SD difference in BMI (OR = 1.20; 95%CI = 1.02-1.41; P = 0.03[ P ＞0.05/64]) was detected. However, no significant heterogeneity was observed between SNPs. Overall causal estimates were consistent between BMI and glaucoma in other two MR methods. Besides, genetically predicted WHRadjBMI (OR = 1.10; 95%CI = 0.85-1.40; P = 0.50), WHR (OR = 1.22;95%CI =0.91-1.62; P = 0.18), and WC (OR = 1.32;95%CI =1.04-1.69; P = 0.03[ P ＞0.05/36]) were not associated with glaucoma. Besides, sensitivity analysis did not find any other directional pleiotropy. Conclusion: The data of this study revealed that the BS, including BMI, WHR, WHRadjBMI, and WC, was not the risk factor for glaucoma." @default.
- W4224265899 created "2022-04-26" @default.
- W4224265899 creator A5011684672 @default.
- W4224265899 creator A5013196274 @default.
- W4224265899 creator A5073973915 @default.
- W4224265899 creator A5080455934 @default.
- W4224265899 creator A5087149818 @default.
- W4224265899 date "2022-04-20" @default.
- W4224265899 modified "2023-10-17" @default.
- W4224265899 title "Body Shape and Risk of Glaucoma: A Mendelian Randomization" @default.
- W4224265899 doi "https://doi.org/10.21203/rs.3.rs-1508541/v1" @default.
- W4224265899 hasPublicationYear "2022" @default.
- W4224265899 type Work @default.
- W4224265899 citedByCount "0" @default.
- W4224265899 crossrefType "posted-content" @default.
- W4224265899 hasAuthorship W4224265899A5011684672 @default.
- W4224265899 hasAuthorship W4224265899A5013196274 @default.
- W4224265899 hasAuthorship W4224265899A5073973915 @default.
- W4224265899 hasAuthorship W4224265899A5080455934 @default.
- W4224265899 hasAuthorship W4224265899A5087149818 @default.
- W4224265899 hasBestOaLocation W42242658991 @default.
- W4224265899 hasConcept C104317684 @default.
- W4224265899 hasConcept C106208931 @default.
- W4224265899 hasConcept C118487528 @default.
- W4224265899 hasConcept C126322002 @default.
- W4224265899 hasConcept C135763542 @default.
- W4224265899 hasConcept C153209595 @default.
- W4224265899 hasConcept C156957248 @default.
- W4224265899 hasConcept C2776193436 @default.
- W4224265899 hasConcept C2778527774 @default.
- W4224265899 hasConcept C2779901538 @default.
- W4224265899 hasConcept C2780221984 @default.
- W4224265899 hasConcept C2993967602 @default.
- W4224265899 hasConcept C33997684 @default.
- W4224265899 hasConcept C44249647 @default.
- W4224265899 hasConcept C54355233 @default.
- W4224265899 hasConcept C61427482 @default.
- W4224265899 hasConcept C71924100 @default.
- W4224265899 hasConcept C86803240 @default.
- W4224265899 hasConceptScore W4224265899C104317684 @default.
- W4224265899 hasConceptScore W4224265899C106208931 @default.
- W4224265899 hasConceptScore W4224265899C118487528 @default.
- W4224265899 hasConceptScore W4224265899C126322002 @default.
- W4224265899 hasConceptScore W4224265899C135763542 @default.
- W4224265899 hasConceptScore W4224265899C153209595 @default.
- W4224265899 hasConceptScore W4224265899C156957248 @default.
- W4224265899 hasConceptScore W4224265899C2776193436 @default.
- W4224265899 hasConceptScore W4224265899C2778527774 @default.
- W4224265899 hasConceptScore W4224265899C2779901538 @default.
- W4224265899 hasConceptScore W4224265899C2780221984 @default.
- W4224265899 hasConceptScore W4224265899C2993967602 @default.
- W4224265899 hasConceptScore W4224265899C33997684 @default.
- W4224265899 hasConceptScore W4224265899C44249647 @default.
- W4224265899 hasConceptScore W4224265899C54355233 @default.
- W4224265899 hasConceptScore W4224265899C61427482 @default.
- W4224265899 hasConceptScore W4224265899C71924100 @default.
- W4224265899 hasConceptScore W4224265899C86803240 @default.
- W4224265899 hasLocation W42242658991 @default.
- W4224265899 hasOpenAccess W4224265899 @default.
- W4224265899 hasPrimaryLocation W42242658991 @default.
- W4224265899 hasRelatedWork W12925555 @default.
- W4224265899 hasRelatedWork W1321646 @default.
- W4224265899 hasRelatedWork W13820118 @default.
- W4224265899 hasRelatedWork W1554878 @default.
- W4224265899 hasRelatedWork W16576623 @default.
- W4224265899 hasRelatedWork W16713355 @default.
- W4224265899 hasRelatedWork W176226 @default.
- W4224265899 hasRelatedWork W3568817 @default.
- W4224265899 hasRelatedWork W3027020 @default.
- W4224265899 hasRelatedWork W6233992 @default.
- W4224265899 isParatext "false" @default.
- W4224265899 isRetracted "false" @default.
- W4224265899 workType "article" @default.