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- W4224267072 abstract "Abstract Parafilm ® is a thermoplastic film extensively used in laboratories for sealing or protecting flasks or cuvettes. In this paper, we report a simple, low-cost, biocompatible and detachable microfluidic chip incorporating easily accessible polymethylmethacrylate (PMMA), PVC and glass slides as the substrate materials, along with Parafilm ® as the bonding material. Multi-layer microfluidic chips can be fabricated by laser ablation followed by thermal fusion of constituent layers. A CO2 laser ablation method was employed to cut substrates as well as the Parafilm ® to obtain desired patterns. A thermal fusion bonding method was developed to bond the substrates in a single step. The patterned Parafilm ® was sandwiched in the PMMA, PVC or glass layers, and heating of the assembly with the addition of a static pressure, various functional microfluidic elements including microvalves, micropumps, and bioreactors were demonstrated. With Parafilm ® serving as a flexible membrane integrated to a fluidic channel, it was possible to implement a microvalve. A peristaltic micropump consisting of a sequence of interconnected gas-actuated microvalves was also fabricated. In addition, the biocompatibility of the PLT (Parafilm ® based laser ablation and thermal fusion bonding fabrication method) fabricated bioreactor was validated by culturing GFP-expressing E. coli, results showed bacterium were able maintain growth in a 7-day post-cultivation. In summary, the reported fabrication scheme, offers an inexpensive and versatile alternative for rapid prototyping of common microfluidic devices." @default.
- W4224267072 created "2022-04-26" @default.
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- W4224267072 date "2022-04-22" @default.
- W4224267072 modified "2023-09-23" @default.
- W4224267072 title "Rapid Prototyping of Parafilm ® -based analytical microfluidic devices using laser ablation and thermal fusion bonding" @default.
- W4224267072 doi "https://doi.org/10.21203/rs.3.rs-1564490/v1" @default.
- W4224267072 hasPublicationYear "2022" @default.
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