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• W4224270488 startingPage "637" @default.
• W4224270488 abstract "Compilation studies related to toxicological aspects and also biological monitoring and analysis methods for specific fungicides and, mainly, those that belong to the class of the dithiocarbamates (DTCs) have not been carried out at least in the last ten years. DTCs - dimethyldithiocarbamates, ethylenebisditiocarbamates, propylenebisditiocarbamates - are organosulfur compounds that form complexes due to the presence of different chemical elements, which bind strongly and inhibit enzymes that are essential to the functioning of the organism, causing a serious proven adverse effect on biological systems, such as alteration of thyroid hormones, teratogenesis and neurotoxicity. It is still evident, as shown by world data, that the growing consumption of fungicides has increasingly exposed the population in general and, in particular, workers who deal with these substances. There is a scarcity of studies in the literature discussing the toxicological and analytical aspects that are important for understanding the real effects of DTCs and monitoring human exposure to them. Therefore, the aim of this work was to expose, in a comprehensive way and through a narrative review, gaps in research related to the fungicides of the DTCs class, their metabolites, as well as the toxicological and analytical aspects involved. The review is divided into two parts: (1) Toxicological aspects, including toxicokinetics, toxicodynamics and toxidromes; and (2) Analytical Toxicology, which comprises biomarkers, sample preparation and identification/quantification methods." @default.
• W4224270488 created "2022-04-26" @default.
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• W4224270488 date "2022-04-19" @default.
• W4224270488 modified "2023-10-16" @default.
• W4224270488 title "Analytical and toxicological aspects of dithiocarbamates: an overview of the last 10 years" @default.
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• W4224270488 doi "https://doi.org/10.1080/15376516.2022.2063096" @default.
• W4224270488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35387549" @default.
• W4224270488 hasPublicationYear "2022" @default.
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