Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224276585> ?p ?o ?g. }
- W4224276585 endingPage "715" @default.
- W4224276585 startingPage "715" @default.
- W4224276585 abstract "Autosomal dominant lateral temporal epilepsy (ADLTE) is a genetic focal epilepsy associated with mutations in the LGI1, RELN, and MICAL1 genes. A previous study linking ADLTE with two MICAL1 mutations that resulted in the substitution of a highly conserved glycine residue for serine (G150S) or a frameshift mutation that swapped the last three C-terminal amino acids for 59 extra residues (A1065fs) concluded that the mutations increased enzymatic activity and promoted cell contraction. The roles of the Molecule Interacting with CasL 1 (MICAL1) protein in tightly regulated semaphorin signaling pathways suggest that activating MICAL1 mutations could result in defects in axonal guidance during neuronal development. Further studies would help to illuminate the causal relationships of these point mutations with ADLTE. In this review, we discuss the proposed pathogenesis caused by mutations in these three genes, with a particular emphasis on the G150S point mutation discovered in MICAL1. We also consider whether these types of activating MICAL1 mutations could be linked to cancer." @default.
- W4224276585 created "2022-04-26" @default.
- W4224276585 creator A5014075940 @default.
- W4224276585 creator A5022119524 @default.
- W4224276585 date "2022-04-19" @default.
- W4224276585 modified "2023-09-24" @default.
- W4224276585 title "MICAL1 Monooxygenase in Autosomal Dominant Lateral Temporal Epilepsy: Role in Cytoskeletal Regulation and Relation to Cancer" @default.
- W4224276585 cites W1549539592 @default.
- W4224276585 cites W1585921586 @default.
- W4224276585 cites W1594091636 @default.
- W4224276585 cites W1924460399 @default.
- W4224276585 cites W1978775660 @default.
- W4224276585 cites W1983101401 @default.
- W4224276585 cites W1989851008 @default.
- W4224276585 cites W1989906394 @default.
- W4224276585 cites W1990988819 @default.
- W4224276585 cites W1997196947 @default.
- W4224276585 cites W2005717712 @default.
- W4224276585 cites W2006849432 @default.
- W4224276585 cites W2007898976 @default.
- W4224276585 cites W2013457408 @default.
- W4224276585 cites W2019358793 @default.
- W4224276585 cites W2026434910 @default.
- W4224276585 cites W2026920505 @default.
- W4224276585 cites W2027937368 @default.
- W4224276585 cites W2030307932 @default.
- W4224276585 cites W2035106144 @default.
- W4224276585 cites W2041580030 @default.
- W4224276585 cites W2042727946 @default.
- W4224276585 cites W2051240384 @default.
- W4224276585 cites W2058034979 @default.
- W4224276585 cites W2058169463 @default.
- W4224276585 cites W2061093792 @default.
- W4224276585 cites W2066411725 @default.
- W4224276585 cites W2072095670 @default.
- W4224276585 cites W2077810031 @default.
- W4224276585 cites W2091970485 @default.
- W4224276585 cites W2092180337 @default.
- W4224276585 cites W2096469131 @default.
- W4224276585 cites W2096525273 @default.
- W4224276585 cites W2099169745 @default.
- W4224276585 cites W2114843025 @default.
- W4224276585 cites W2121952176 @default.
- W4224276585 cites W2124248841 @default.
- W4224276585 cites W2126546276 @default.
- W4224276585 cites W2149441684 @default.
- W4224276585 cites W2150631693 @default.
- W4224276585 cites W2152504257 @default.
- W4224276585 cites W2164489995 @default.
- W4224276585 cites W2165472416 @default.
- W4224276585 cites W2253067200 @default.
- W4224276585 cites W2329437993 @default.
- W4224276585 cites W2334761538 @default.
- W4224276585 cites W2405726303 @default.
- W4224276585 cites W2506658849 @default.
- W4224276585 cites W2538771349 @default.
- W4224276585 cites W2543042652 @default.
- W4224276585 cites W2582315334 @default.
- W4224276585 cites W2622156717 @default.
- W4224276585 cites W2724694019 @default.
- W4224276585 cites W2783365622 @default.
- W4224276585 cites W2792238625 @default.
- W4224276585 cites W2802005789 @default.
- W4224276585 cites W2926208205 @default.
- W4224276585 cites W2969440380 @default.
- W4224276585 cites W2996683067 @default.
- W4224276585 cites W3120307467 @default.
- W4224276585 cites W3166773827 @default.
- W4224276585 cites W3185152062 @default.
- W4224276585 cites W3198643386 @default.
- W4224276585 cites W3213197832 @default.
- W4224276585 cites W4200518459 @default.
- W4224276585 cites W4205440119 @default.
- W4224276585 cites W4289274885 @default.
- W4224276585 doi "https://doi.org/10.3390/genes13050715" @default.
- W4224276585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35627100" @default.
- W4224276585 hasPublicationYear "2022" @default.
- W4224276585 type Work @default.
- W4224276585 citedByCount "1" @default.
- W4224276585 countsByYear W42242765852023 @default.
- W4224276585 crossrefType "journal-article" @default.
- W4224276585 hasAuthorship W4224276585A5014075940 @default.
- W4224276585 hasAuthorship W4224276585A5022119524 @default.
- W4224276585 hasBestOaLocation W42242765851 @default.
- W4224276585 hasConcept C104317684 @default.
- W4224276585 hasConcept C11960822 @default.
- W4224276585 hasConcept C132538176 @default.
- W4224276585 hasConcept C169760540 @default.
- W4224276585 hasConcept C170493617 @default.
- W4224276585 hasConcept C176944494 @default.
- W4224276585 hasConcept C2776414213 @default.
- W4224276585 hasConcept C2778186239 @default.
- W4224276585 hasConcept C2779841796 @default.
- W4224276585 hasConcept C29906990 @default.
- W4224276585 hasConcept C501734568 @default.
- W4224276585 hasConcept C54355233 @default.
- W4224276585 hasConcept C86803240 @default.
- W4224276585 hasConceptScore W4224276585C104317684 @default.