FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224284250> ?p ?o ?g. }

• W4224284250 abstract "Background: Due to the insufficient understanding of the biological mechanisms, the improvement of therapeutic effects of prostate cancer (PCa) is limited. There is an urgent need to find the molecular mechanisms and underlying PCa to improve its early diagnosis, treatment, and prognosis. Methods: The mRNA expression profiles, survival and methylation data of PRAD were downloaded from The Cancer Genome Atlas (TCGA) database. The identification of differentially expressed genes (DEGs), Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analyses were performed by R software. Subsequently, we identified the key gene and validated its prognostic role from the Human Protein Atlas (HPA) database, UALCAN and the LinkedOmics database. We performd correlation analysis and constructed the ceRNA network based on the data obtained from miRbase and starBase. Finally, we performed methylation analysis and evaluated the immune cell infiltration by Tumor Immune Estimation Resource (TIMER). Results: A total of 567 DEGs were identified in PCa. ARHGEF38, SLPI, EpCAM, C1QTNF1, and HBB were regarded as target genes related to favorable overall survival (OS). Among them, EpCAM was considered as the most significant gene through the HPA database and receiver operating characteristic (ROC) analysis. A prognostic ceRNA network was constructed with EBLN3P, miR-204-5p, and EpCAM. EpCAM was found to be related to DNA methylation and tumor-infiltrating immune cells. Conclusion: Our findings provide novel insights into the tumorigenesis mechanism of PCa and contribute to the development of EpCAM as a potential prognostic biomarker in PCa." @default.
• W4224284250 created "2022-04-26" @default.
• W4224284250 creator A5014297063 @default.
• W4224284250 creator A5022244006 @default.
• W4224284250 creator A5042250944 @default.
• W4224284250 creator A5076444339 @default.
• W4224284250 creator A5081489470 @default.
• W4224284250 date "2022-04-20" @default.
• W4224284250 modified "2023-10-18" @default.
• W4224284250 title "EpCAM as a Novel Biomarker for Survivals in Prostate Cancer Patients" @default.
• W4224284250 cites W1572810235 @default.
• W4224284250 cites W2012034410 @default.
• W4224284250 cites W2048025181 @default.
• W4224284250 cites W2071271349 @default.
• W4224284250 cites W2117977572 @default.
• W4224284250 cites W2159675211 @default.
• W4224284250 cites W2163199119 @default.
• W4224284250 cites W2511288941 @default.
• W4224284250 cites W2526592100 @default.
• W4224284250 cites W2616701769 @default.
• W4224284250 cites W2735687500 @default.
• W4224284250 cites W2736730167 @default.
• W4224284250 cites W2767377392 @default.
• W4224284250 cites W2767883250 @default.
• W4224284250 cites W2784570320 @default.
• W4224284250 cites W2791506113 @default.
• W4224284250 cites W2858268852 @default.
• W4224284250 cites W2898440040 @default.
• W4224284250 cites W2900569176 @default.
• W4224284250 cites W2901588705 @default.
• W4224284250 cites W2902954996 @default.
• W4224284250 cites W2904249129 @default.
• W4224284250 cites W2904953089 @default.
• W4224284250 cites W2912991678 @default.
• W4224284250 cites W2953428282 @default.
• W4224284250 cites W2964818755 @default.
• W4224284250 cites W2973602287 @default.
• W4224284250 cites W2981556815 @default.
• W4224284250 cites W2982350961 @default.
• W4224284250 cites W2983877246 @default.
• W4224284250 cites W2990795623 @default.
• W4224284250 cites W3000433417 @default.
• W4224284250 cites W3027286012 @default.
• W4224284250 cites W3028488594 @default.
• W4224284250 cites W3030794881 @default.
• W4224284250 cites W3033457790 @default.
• W4224284250 cites W3084345333 @default.
• W4224284250 cites W3089307410 @default.
• W4224284250 cites W3090836672 @default.
• W4224284250 cites W3111149356 @default.
• W4224284250 cites W3123335024 @default.
• W4224284250 cites W3128646645 @default.
• W4224284250 doi "https://doi.org/10.3389/fcell.2022.843604" @default.
• W4224284250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35517503" @default.
• W4224284250 hasPublicationYear "2022" @default.
• W4224284250 type Work @default.
• W4224284250 citedByCount "4" @default.
• W4224284250 countsByYear W42242842502023 @default.
• W4224284250 crossrefType "journal-article" @default.
• W4224284250 hasAuthorship W4224284250A5014297063 @default.
• W4224284250 hasAuthorship W4224284250A5022244006 @default.
• W4224284250 hasAuthorship W4224284250A5042250944 @default.
• W4224284250 hasAuthorship W4224284250A5076444339 @default.
• W4224284250 hasAuthorship W4224284250A5081489470 @default.
• W4224284250 hasBestOaLocation W42242842501 @default.
• W4224284250 hasConcept C104317684 @default.
• W4224284250 hasConcept C121608353 @default.
• W4224284250 hasConcept C150194340 @default.
• W4224284250 hasConcept C152724338 @default.
• W4224284250 hasConcept C190727270 @default.
• W4224284250 hasConcept C2780192828 @default.
• W4224284250 hasConcept C2987395477 @default.
• W4224284250 hasConcept C33288867 @default.
• W4224284250 hasConcept C41008148 @default.
• W4224284250 hasConcept C502942594 @default.
• W4224284250 hasConcept C54355233 @default.
• W4224284250 hasConcept C555283112 @default.
• W4224284250 hasConcept C60365752 @default.
• W4224284250 hasConcept C62203573 @default.
• W4224284250 hasConcept C67705224 @default.
• W4224284250 hasConcept C70721500 @default.
• W4224284250 hasConcept C77088390 @default.
• W4224284250 hasConcept C86803240 @default.
• W4224284250 hasConceptScore W4224284250C104317684 @default.
• W4224284250 hasConceptScore W4224284250C121608353 @default.
• W4224284250 hasConceptScore W4224284250C150194340 @default.
• W4224284250 hasConceptScore W4224284250C152724338 @default.
• W4224284250 hasConceptScore W4224284250C190727270 @default.
• W4224284250 hasConceptScore W4224284250C2780192828 @default.
• W4224284250 hasConceptScore W4224284250C2987395477 @default.
• W4224284250 hasConceptScore W4224284250C33288867 @default.
• W4224284250 hasConceptScore W4224284250C41008148 @default.
• W4224284250 hasConceptScore W4224284250C502942594 @default.
• W4224284250 hasConceptScore W4224284250C54355233 @default.
• W4224284250 hasConceptScore W4224284250C555283112 @default.
• W4224284250 hasConceptScore W4224284250C60365752 @default.
• W4224284250 hasConceptScore W4224284250C62203573 @default.
• W4224284250 hasConceptScore W4224284250C67705224 @default.
• W4224284250 hasConceptScore W4224284250C70721500 @default.
• W4224284250 hasConceptScore W4224284250C77088390 @default.

• next