Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224285105> ?p ?o ?g. }
- W4224285105 abstract "Background Renal cell carcinoma is difficult to diagnose and unpredictable in disease course and severity. There are no specific biomarkers for diagnosis and prognosis estimation feasible in clinical practice. Long non-coding RNAs (lncRNAs) have emerged as potent regulators of gene expression in recent years. Aside from their cellular role, their expression patterns could be used as a biomarker of ongoing pathology. Methods In this work, we used next-generation sequencing for global lncRNA expression profiling in tumor and non-tumor tissue of RCC patients. The four candidate lncRNAs have been further validated on an independent cohort. PVT1, as the most promising lncRNA, has also been studied using functional in vitro tests. Results Next-generation sequencing showed significant dysregulation of 1163 lncRNAs; among them top 20 dysregulated lncRNAs were AC061975.7, AC124017.1, AP000696.1, AC148477.4, LINC02437, GATA3-AS, LINC01762, LINC01230, LINC01271, LINC01187, LINC00472, AC007849.1, LINC00982, LINC01543, AL031710.1, and AC019197.1 as down-regulated lncRNAs; and SLC16A1-AS1, PVT1, LINC0887, and LUCAT1 as up-regulated lncRNAs. We observed statistically significant dysregulation of PVT1, LUCAT1, and LINC00982. Moreover, we studied the effect of artificial PVT1 decrease in renal cell line 786–0 and observed an effect on cell viability and migration. Conclusion Our results show not only the diagnostic but also the therapeutic potential of PVT1 in renal cell carcinoma." @default.
- W4224285105 created "2022-04-26" @default.
- W4224285105 creator A5008071901 @default.
- W4224285105 creator A5017583074 @default.
- W4224285105 creator A5020924094 @default.
- W4224285105 creator A5068788338 @default.
- W4224285105 creator A5069592985 @default.
- W4224285105 creator A5076063326 @default.
- W4224285105 creator A5090844895 @default.
- W4224285105 date "2022-04-20" @default.
- W4224285105 modified "2023-10-06" @default.
- W4224285105 title "LncRNA PVT1 is increased in renal cell carcinoma and affects viability and migration in vitro" @default.
- W4224285105 cites W1268537320 @default.
- W4224285105 cites W1938121151 @default.
- W4224285105 cites W1964713316 @default.
- W4224285105 cites W1989519457 @default.
- W4224285105 cites W1999574084 @default.
- W4224285105 cites W2033167804 @default.
- W4224285105 cites W2036897871 @default.
- W4224285105 cites W2109895094 @default.
- W4224285105 cites W2124996418 @default.
- W4224285105 cites W2169456326 @default.
- W4224285105 cites W2179438025 @default.
- W4224285105 cites W2345998278 @default.
- W4224285105 cites W2398313285 @default.
- W4224285105 cites W2402883299 @default.
- W4224285105 cites W2494776653 @default.
- W4224285105 cites W2509610924 @default.
- W4224285105 cites W251358359 @default.
- W4224285105 cites W2592207055 @default.
- W4224285105 cites W2625600561 @default.
- W4224285105 cites W2739974743 @default.
- W4224285105 cites W2759765856 @default.
- W4224285105 cites W2763101444 @default.
- W4224285105 cites W2765762016 @default.
- W4224285105 cites W2767156272 @default.
- W4224285105 cites W2774490145 @default.
- W4224285105 cites W2792063645 @default.
- W4224285105 cites W2796207353 @default.
- W4224285105 cites W2809636636 @default.
- W4224285105 cites W2884059633 @default.
- W4224285105 cites W2887490431 @default.
- W4224285105 cites W2907603936 @default.
- W4224285105 cites W3024966236 @default.
- W4224285105 cites W3120377060 @default.
- W4224285105 cites W3128646645 @default.
- W4224285105 cites W3158107846 @default.
- W4224285105 cites W3162185588 @default.
- W4224285105 cites W4224285105 @default.
- W4224285105 cites W4294358748 @default.
- W4224285105 doi "https://doi.org/10.1002/jcla.24442" @default.
- W4224285105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35441392" @default.
- W4224285105 hasPublicationYear "2022" @default.
- W4224285105 type Work @default.
- W4224285105 citedByCount "3" @default.
- W4224285105 countsByYear W42242851052022 @default.
- W4224285105 countsByYear W42242851052023 @default.
- W4224285105 crossrefType "journal-article" @default.
- W4224285105 hasAuthorship W4224285105A5008071901 @default.
- W4224285105 hasAuthorship W4224285105A5017583074 @default.
- W4224285105 hasAuthorship W4224285105A5020924094 @default.
- W4224285105 hasAuthorship W4224285105A5068788338 @default.
- W4224285105 hasAuthorship W4224285105A5069592985 @default.
- W4224285105 hasAuthorship W4224285105A5076063326 @default.
- W4224285105 hasAuthorship W4224285105A5090844895 @default.
- W4224285105 hasBestOaLocation W42242851052 @default.
- W4224285105 hasConcept C104317684 @default.
- W4224285105 hasConcept C143998085 @default.
- W4224285105 hasConcept C1491633281 @default.
- W4224285105 hasConcept C2777394393 @default.
- W4224285105 hasConcept C2777472916 @default.
- W4224285105 hasConcept C2777546739 @default.
- W4224285105 hasConcept C2781197716 @default.
- W4224285105 hasConcept C2781278892 @default.
- W4224285105 hasConcept C502942594 @default.
- W4224285105 hasConcept C53227056 @default.
- W4224285105 hasConcept C54355233 @default.
- W4224285105 hasConcept C60365752 @default.
- W4224285105 hasConcept C60644358 @default.
- W4224285105 hasConcept C62203573 @default.
- W4224285105 hasConcept C67705224 @default.
- W4224285105 hasConcept C71924100 @default.
- W4224285105 hasConcept C86803240 @default.
- W4224285105 hasConceptScore W4224285105C104317684 @default.
- W4224285105 hasConceptScore W4224285105C143998085 @default.
- W4224285105 hasConceptScore W4224285105C1491633281 @default.
- W4224285105 hasConceptScore W4224285105C2777394393 @default.
- W4224285105 hasConceptScore W4224285105C2777472916 @default.
- W4224285105 hasConceptScore W4224285105C2777546739 @default.
- W4224285105 hasConceptScore W4224285105C2781197716 @default.
- W4224285105 hasConceptScore W4224285105C2781278892 @default.
- W4224285105 hasConceptScore W4224285105C502942594 @default.
- W4224285105 hasConceptScore W4224285105C53227056 @default.
- W4224285105 hasConceptScore W4224285105C54355233 @default.
- W4224285105 hasConceptScore W4224285105C60365752 @default.
- W4224285105 hasConceptScore W4224285105C60644358 @default.
- W4224285105 hasConceptScore W4224285105C62203573 @default.
- W4224285105 hasConceptScore W4224285105C67705224 @default.
- W4224285105 hasConceptScore W4224285105C71924100 @default.
- W4224285105 hasConceptScore W4224285105C86803240 @default.