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- W4224286391 abstract "The lung is the primary site of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced immunopathology whereby the virus enters the host cells by binding to angiotensin-converting enzyme 2 (ACE2). Sophisticated regeneration and repair programs exist in the lungs to replenish injured cell populations. However, known resident stem/progenitor cells have been demonstrated to express ACE2, raising a substantial concern regarding the long-term consequences of impaired lung regeneration after SARS-CoV-2 infection. Moreover, clinical treatments may also affect lung repair from antiviral drug candidates to mechanical ventilation. In this review, we highlight how SARS-CoV-2 disrupts a program that governs lung homeostasis. We also summarize the current efforts of targeted therapy and supportive treatments for COVID-19 patients. In addition, we discuss the pros and cons of cell therapy with mesenchymal stem cells or resident lung epithelial stem/progenitor cells in preventing post-acute sequelae of COVID-19. We propose that, in addition to symptomatic treatments being developed and applied in the clinic, targeting lung regeneration is also essential to restore lung homeostasis in COVID-19 patients." @default.
- W4224286391 created "2022-04-26" @default.
- W4224286391 creator A5004265635 @default.
- W4224286391 creator A5019085001 @default.
- W4224286391 creator A5023293666 @default.
- W4224286391 creator A5042267450 @default.
- W4224286391 date "2022-04-20" @default.
- W4224286391 modified "2023-10-07" @default.
- W4224286391 title "SARS-CoV-2 Infection and Lung Regeneration" @default.
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