FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4224287102> ?p ?o ?g. }

• W4224287102 abstract "“The locally denervated but biologically supported heart is a physiologic tool of great importance in the study of myocardial function and pharmacologic response,” once said Richard Lower and Normal Shumway, the pioneers of heart transplantation. 1 Dong E Lower RR Hurley EJ Shumway NE. Transplantation of the heart. Dis Chest. 1965; 48: 455-457 Abstract Full Text Full Text PDF PubMed Scopus (3) Google Scholar Indeed, the autonomic nervous system influences nearly every facet of cardiac function including chronotropy, dromotropy, inotropy, and vasomotor function (Table 1). At the time of cardiac allograft procurement, the nerve inputs are inexorably severed. The absence of direct sympathetic cardiac input hampers the allograft's responsiveness to physiological demands, as the transplanted heart instead becomes dependent on the more gradual changes in circulating catecholamines for chronotropic and inotropic stimulation. Without parasympathetic regulation, the newly transplanted heart exhibits a higher resting heart rate (HR), reduced heart rate variability (HRV) and blunted or paradoxical responses to cholinergic medications. In their seminal observations with homo- and auto-transplantation in canines, Lower and Shumway noted evidence of complete cardiac denervation in the early postoperative phase; variable reappearance of heart rate responses to direct sympathetic and parasympathetic stimulation did not occur until at least 3 months after the operation. 1 Dong E Lower RR Hurley EJ Shumway NE. Transplantation of the heart. Dis Chest. 1965; 48: 455-457 Abstract Full Text Full Text PDF PubMed Scopus (3) Google Scholar Table 1Sympathetic and Parasympathetic Systems and the Heart: Normal Physiology, Diagnostic Evaluation And Post-Transplant Reinnervation Sympathetic Innervation Parasympathetic Innervation Anatomy •Cardiac Cervical nerves (superior, medium, inferior) •Cardiac Thoracic nerves •Vagal nerves (right, left) Physiologic effects a Normal responses to autonomic nervous system signaling are lost at heart transplantation due to surgical interruption of sympathetic cardiac nerves and vagal nerves, leading to allograft dependency on circulating catecholamines for heart rate, contractility, and coronary vascular tone modulation. •↑HR* •↑conduction velocity (SA node, AV node, atria, ventricles)* •↑contractility (atria, ventricles)* •coronary arteries constriction ** •coronary arteries dilation*** •↓HR# •↑conduction velocity (SA node)# ↓conduction velocity (AV node)# •↓contractility (atria)# •coronary arteries dilation## Functional measurements •Non-invasive: HRV analysis •Invasive: ‐coronary arterio-venous spillover of norepinephrine to tyramine or handgrip stimulation ‐measurement of catecholamines in endomyocardial biopsy samples •Noninvasive: HRV analysis; Baroreceptor sensitivity responses Imaging ‐ Imaging of pre- and post-synaptic norepinephrine derivates (ex.: [123 I]-MIBG with SPECT; [11C]-mHED or [11C]-epinephrine with PET)‐ Imaging of adrenoreceptors with labeled receptor antagonists (ex.: [11C]-CGP-12177 with PET) Imaging of post-synaptic muscarinic receptors (ex.: [11C]-Me-QNB or 2-[18F]-F-A-85380 with PET) Evidence of post-transplantation re-innervation •shown at 6 months to 1 year post HTx •not shown in early studies with atrial anastomosis technique •emerging evidence since implementation of bicaval technique •late onset (>1 year post HTx) Pattern of reinnervation post-transplantation •incomplete, regionally limited •gradient propagation from basal segments distally •starts with LAD territory, later in LCx territory (RCA distribution not shown) •not defined (SA vs AV) Clinical implications of post-transplantation reinnervation •improved HR response to exercise •improved regional and global contractility responses to stress •improved exercise capacity •clinical endpoints to be determined •improved QOL Effect via adrenergic receptors: *β1 and β2; **α1 and α2; ***β2. Effect via cholinergic muscarinic receptors: #M2; ##M3. AV, Atrioventricular; HR, heart rate; HRV, heart rate variability; HTx, heart transplant; LAD, left anterior descending artery; LCx, left circumflex artery; QOL, quality of life; SA, Sinoatrial. a Normal responses to autonomic nervous system signaling are lost at heart transplantation due to surgical interruption of sympathetic cardiac nerves and vagal nerves, leading to allograft dependency on circulating catecholamines for heart rate, contractility, and coronary vascular tone modulation. Open table in a new tab Effect via adrenergic receptors: *β1 and β2; **α1 and α2; ***β2. Effect via cholinergic muscarinic receptors: #M2; ##M3. AV, Atrioventricular; HR, heart rate; HRV, heart rate variability; HTx, heart transplant; LAD, left anterior descending artery; LCx, left circumflex artery; QOL, quality of life; SA, Sinoatrial." @default.
• W4224287102 created "2022-04-26" @default.
• W4224287102 creator A5012011282 @default.
• W4224287102 creator A5080887465 @default.
• W4224287102 date "2022-04-01" @default.
• W4224287102 modified "2023-09-27" @default.
• W4224287102 title "You've Got Some Nerve (after Heart Transplantation)" @default.
• W4224287102 cites W1974441211 @default.
• W4224287102 cites W1974703880 @default.
• W4224287102 cites W1977408829 @default.
• W4224287102 cites W1983290905 @default.
• W4224287102 cites W1989527026 @default.
• W4224287102 cites W2004271293 @default.
• W4224287102 cites W2012751656 @default.
• W4224287102 cites W2040537723 @default.
• W4224287102 cites W2060275689 @default.
• W4224287102 cites W2062058244 @default.
• W4224287102 cites W2063342008 @default.
• W4224287102 cites W2075573737 @default.
• W4224287102 cites W2078348682 @default.
• W4224287102 cites W2082196328 @default.
• W4224287102 cites W2085725471 @default.
• W4224287102 cites W2092355203 @default.
• W4224287102 cites W2110620979 @default.
• W4224287102 cites W2113700662 @default.
• W4224287102 cites W2124383642 @default.
• W4224287102 cites W2142512824 @default.
• W4224287102 cites W2165955383 @default.
• W4224287102 cites W2305467247 @default.
• W4224287102 cites W3030330319 @default.
• W4224287102 cites W3110830896 @default.
• W4224287102 doi "https://doi.org/10.1016/j.healun.2022.02.024" @default.
• W4224287102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35581138" @default.
• W4224287102 hasPublicationYear "2022" @default.
• W4224287102 type Work @default.
• W4224287102 citedByCount "0" @default.
• W4224287102 crossrefType "journal-article" @default.
• W4224287102 hasAuthorship W4224287102A5012011282 @default.
• W4224287102 hasAuthorship W4224287102A5080887465 @default.
• W4224287102 hasConcept C111566952 @default.
• W4224287102 hasConcept C126322002 @default.
• W4224287102 hasConcept C155710745 @default.
• W4224287102 hasConcept C158328960 @default.
• W4224287102 hasConcept C164705383 @default.
• W4224287102 hasConcept C2777372248 @default.
• W4224287102 hasConcept C2777953023 @default.
• W4224287102 hasConcept C2778198053 @default.
• W4224287102 hasConcept C2778849806 @default.
• W4224287102 hasConcept C2779740467 @default.
• W4224287102 hasConcept C2911091166 @default.
• W4224287102 hasConcept C71924100 @default.
• W4224287102 hasConcept C84393581 @default.
• W4224287102 hasConceptScore W4224287102C111566952 @default.
• W4224287102 hasConceptScore W4224287102C126322002 @default.
• W4224287102 hasConceptScore W4224287102C155710745 @default.
• W4224287102 hasConceptScore W4224287102C158328960 @default.
• W4224287102 hasConceptScore W4224287102C164705383 @default.
• W4224287102 hasConceptScore W4224287102C2777372248 @default.
• W4224287102 hasConceptScore W4224287102C2777953023 @default.
• W4224287102 hasConceptScore W4224287102C2778198053 @default.
• W4224287102 hasConceptScore W4224287102C2778849806 @default.
• W4224287102 hasConceptScore W4224287102C2779740467 @default.
• W4224287102 hasConceptScore W4224287102C2911091166 @default.
• W4224287102 hasConceptScore W4224287102C71924100 @default.
• W4224287102 hasConceptScore W4224287102C84393581 @default.
• W4224287102 hasLocation W42242871021 @default.
• W4224287102 hasLocation W42242871022 @default.
• W4224287102 hasOpenAccess W4224287102 @default.
• W4224287102 hasPrimaryLocation W42242871021 @default.
• W4224287102 hasRelatedWork W1605393884 @default.
• W4224287102 hasRelatedWork W1995784099 @default.
• W4224287102 hasRelatedWork W2004590959 @default.
• W4224287102 hasRelatedWork W2385310492 @default.
• W4224287102 hasRelatedWork W2407024500 @default.
• W4224287102 hasRelatedWork W2407717929 @default.
• W4224287102 hasRelatedWork W2460321185 @default.
• W4224287102 hasRelatedWork W3036884653 @default.
• W4224287102 hasRelatedWork W4224287102 @default.
• W4224287102 hasRelatedWork W2521110514 @default.
• W4224287102 isParatext "false" @default.
• W4224287102 isRetracted "false" @default.
• W4224287102 workType "article" @default.